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Dataset results
186 results for “erythrocytes”
COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial
ClinicalTrials.gov study NCT06425614. IPD Sharing: YES. Countries: 1. Publications: 1.
Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT01523782. IPD Sharing: NO. Countries: 0. Publications: 1.
Erythrocytes-Mediated Delivery Of Dexamethasone 21-Phosphate In Steroid-Dependent Ulcerative Colitis
ClinicalTrials.gov study NCT01171807. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Telangiectasia Patients
ClinicalTrials.gov study NCT02770807. IPD Sharing: NO. Countries: 12. Publications: 2.
Data from: Transmission pathways and spillover of an erythrocytic bacterial pathogen from domestic cats to wild felids
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DNA replication dynamics during erythrocytic schizogony in the malaria parasites Plasmodium falciparum and Plasmodium knowlesi
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Data from: Diverging trends in erythrocyte size elucidate cardiovascular evolution in stem dinosaurs and crocodilians
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Data from: Antibody responses to Plasmodium vivax Duffy binding and erythrocyte binding proteins predict risk of infection and are associated with protection from clinical malaria
Background. The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, the functional receptor-binding region II of PvDBP (PvDBPII) is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBPII, including AH, O, P and Sal1 alleles, the central region III-V, and P. vivax Erythrocyte Binding Protein region II (PvEBPII) and their associations with risk of clinical P. vivax malaria are not well understood. Methodology. Total IgG and IgG subclasses 1, 2, and 3 that recognize four alleles of PvDBPII (AH, O, P, and Sal1), PvDBPIII-V and region II of PvEBP (PvEBPII) were measured in samples collected from a cohort of Papua New Guinean (PNG) children of aged 1-3 years living in a highly endemic area of PNG. The levels of binding inhibitory antibodies (BIAbs) to PvDBPII (AH, O, and Sal1) were also tested in a subset of children. The association of presence of IgG with age, cumulative exposure (measured as the product of age and malaria infections during follow-up, i.e. molFOB) and prospective risk of clinical malaria were evaluated. Results. Increase in antigen-specific total IgG, IgG1, and IgG3 with age and cumulative exposure was only observed for PvDBPII AH and PvEBPII. High total IgG responders and IgG3 specific responses to the predominant PvDBPII AH allele, were associated with decreased incidence of clinical P. vivax episodes (aIRR=0.56-0.68, P=<0.001-0.021 ). High total IgG and IgG1 to PvEBPII correlated more strongly with protection against clinical vivax malaria compared with those of all PvDBPII variants (aIRR=0.38, P<0.001). Antibodies to PvDBPII AH and PvEBPII showed evidence of an additive effect, with a joint protective association of 70%. The six children with high levels of Binding Inhibitory Antibodies (BIAbs) to PvDBPII and high strain-transcending blocking ability (i.e. >80%) tended to have less clinical diseases (IRR=0.45, P=0.083). Conclusion. Antibodies to the key parasite invasion ligands PvDBPII and PvEBPII are good correlates of protection against P. vivax malaria in PNG. This further strengthens the rationale for inclusion of PvDBPII in a recombinant subunit vaccine for P. vivax malaria and highlights the need for further functional studies to determine the potential of PvEBPII as a component of a subunit vaccine for P. vivax malaria.
Data from: Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation
The adverse effect induced by carbon ion radiation (CIR) is still an unavoidable hazard to the treatment object. Thus, evaluation of its adverse effects on the body is a critical problem with respect to radiation therapy. We aimed to investigate the change between the configuration and mechanical properties of erythrocytes induced by radiation and found differences in both the configuration and the mechanical properties with involving in morphological remodeling process. Syrian hamsters were subjected to whole-body irradiation with carbon ion beams (1, 2, 4, and 6 Gy) or X-rays (2, 4, 6, and 12 Gy) for 3, 14 and 28 days. Erythrocytes in peripheral blood and bone marrow were collected for cytomorphological analysis. The mechanical properties of the erythrocytes were determined using atomic force microscopy, and the expression of the cytoskeletal protein spectrin-α1 was analyzed via western blotting. The results showed that dynamic changes were evident in erythrocytes exposed to different doses of carbon ion beams compared with X-rays and the control (0 Gy). The magnitude of impairment of the cell number and cellular morphology manifested the subtle variation according to the irradiation dose. In particular, the differences in the size, shape and mechanical properties of the erythrocytes were well exhibited. Furthermore, immunoblot data showed that the expression of the cytoskeletal protein spectrin-α1 was changed after irradiation, and there was a common pattern among its substantive characteristics in the irradiated group. Based on these findings, the present study concluded that CIR could induce a change in mechanical properties during morphological remodeling of erythrocytes. According to the unique characteristics of the biomechanical categories, we deduce that changes in cytomorphology and mechanical properties can be measured to evaluate the adverse effects generated by tumor radiotherapy. Additionally, for the first time, the current study provides a new strategy for enhancing the assessment of the curative effects and safety of clinical radiotherapy, as well as reducing adverse effects.
FIGURE 2 in Erythrocyte nuclear size as a better diagnostic character than cell size in the identification of live cryptic polyploid species
FIGURE 2. Comparison of nuclear areas of the individuals included in the estimation of boundary values (A) and the remaining individuals (B) of Odontophrynus cordobae and O. americanus. The dotted line represents the limit nuclear area to separate species. Upper and lower ends of boxes represent 75th and 25th percentiles. Whiskers represent the minimum and the maximum values. The center line within each box shows the locations of the sample median and the plus sign indicates the location of the sample mean.
FIGURE 1 in Erythrocyte nuclear size as a better diagnostic character than cell size in the identification of live cryptic polyploid species
FIGURE 1. Comparison of nuclear areas of the individuals included in the estimation of boundary values (A) and the remaining individuals (B) of Pleurodema kriegi and P. cordobae. The dotted line represents the limit nuclear area to separate species. Upper and lower ends of boxes represent 75th and 25th percentiles. Whiskers represent the minimum and the maximum values, except for outlier points. The center line within each box shows the locations of the sample median and the plus sign indicates the location of the sample mean.
Supplementary videos erythrocytes 1 & 2
<p><strong>Video S1</strong>. The movement of the erythrocytes by the simulation. <strong>Video S2</strong>: zoom views of the bifurcation and of the main straight portions of the channels</p>
Antibody features towards VAR2CSA and CSA binding infected erythrocytes in a cohort of pregnant women from PNG
<p><i>Plasmodium falciparum </i>causes placental malaria, which results in adverse outcomes for mother and child. <i>P. falciparum</i> infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfate-A. It has been hypothesized that naturally acquired antibodies towards VAR2CSA protect against placental infection, but it has proven difficult to use measures of antibody to identify individuals protected from disease. We used a systems serology approach to identify naturally acquired antibody features mid pregnancy that were associated with protection from placental malaria at delivery. Machine learning techniques selected six out of 169 measured antibody features towards VAR2CSA that could predict (with 86% accuracy) whether a woman would subsequently have active placental malaria infection at delivery. Selected features were associated with inhibition of placental binding and/or opsonic phagocytosis of infected erythrocytes, and network analysis indicated that there are not one but multiple pathways to protection from placental malaria.</p>
The Impact of Oxidative Stress on Erythrocyte Biology
ClinicalTrials.gov study NCT04028700. IPD Sharing: YES. Countries: 1. Publications: 0.
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease
ClinicalTrials.gov study NCT01707719. IPD Sharing: NO. Countries: 1. Publications: 17.
Erythrocyte Ghost Mediated Retinal Diagnosis
ClinicalTrials.gov study NCT02445001. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long Term Effects of Erythrocyte Lysis
ClinicalTrials.gov study NCT00842621. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase)in Patients With Pancreatic Cancer
ClinicalTrials.gov study NCT01523808. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT02992548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
A Controlled Human Vivax Malaria Infection Study Through Inoculation of Infected Erythrocytes
ClinicalTrials.gov study NCT05071079. IPD Sharing: YES. Countries: 1. Publications: 22.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.