Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
342
datasets available to search
ShareScore release 0.9.0
Dataset results
342 results for “extracellular matrix”
Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection
Open the record for dataset details and reuse information.
Crosstalk between Mast Cells and Lung Fibroblasts Is Modified by Alveolar Extracellular Matrix and Influences Epithelial Migration
<p>Datasets for the data generated and presented in the article: https://doi.org/10.3390/ijms22020506</p>
Data and Codebase on Extracellular Matrix Remodeling from Embedded Spheroid Fluidization Experiments
<p>raw data: 52_025.zip, 52_100.zip, 54_025.zip, 54_100.zip, 56_025.zip, 56_100.zip, 58_025.zip, 58_100.zip</p> <p>analysis data: Archive.zip, README.MD</p> <p>codebase: codebase.zip</p>
Data from: Extracellular matrix-associated gene expression in adult sensory neurons cultured on laminin substrates
Background: In our previous investigations of the role of the extracellular matrix (ECM) in promoting neurite growth we have observed that a permissive laminin (LN) substrate stimulates differential growth responses in subpopulations of mature dorsal root ganglion (DRG) neurons. DRG neurons expressing Trk and p75 receptors grow neurites on a LN substrate in the absence of neurotrophins, while isolectin B4-binding neurons (IB4+) do not display significant growth under the same conditions. We set out to determine whether there was an expression signature of the LN-induced neurite growth phenotype. Using a lectin binding protocol IB4+ neurons were isolated from dissociated DRG neurons, creating two groups - IB4+ and IB4-. A small-scale microarray approach was employed to screen the expression of a panel of ECM-associated genes following dissociation (t=0) and after 24 hr culture on LN (t=24LN). This was followed by qRT-PCR and immunocytochemistry of selected genes. Results: The microarray screen showed that 36 of the 144 genes on the arrays were consistently expressed by the neurons. The array analyses showed that six genes had lower expression in the IB4+ neurons compared to the IB4- cells at t=0 (CTSH, Icam1, Itgβ1, Lamb1, Plat, Spp1), and one gene was expressed at higher levels in the IB4+ cells (Plaur). qRT-PCR was carried out as an independent assessment of the array results. There were discrepancies between the two methods, with qRT-PCR confirming the differences in Lamb1, Plat and Plaur, and showing decreased expression of AdamTs1, FN, and Icam in the IB4+ cells at t=0. After 24 hr culture on LN, there were no significant differences detected by qRT-PCR between the IB4+ and IB4- cells. However, both groups showed upregulation of Itgβ1 and Plaur after 24 hr on LN, the IB4+ group also had increased Plat, and the IB4- cells showed decreased Lamb1, Icam1 and AdamTs1. Further, the array screen also detected a number of genes (not subjected to qRT-PCR) expressed similarly by both populations in relatively high levels but not detectably influenced by time in culture (Bsg, Cst3, Ctsb, Ctsd, Ctsl, Mmp14, Mmp19, Sparc. We carried out immunohistochemistry to confirm expression of proteins encoded by a number of these genes. Conclusions:Our results show that 1B4+ and IB4- neurons differ in the expression of several genes that are associated with responsiveness to the ECM prior to culturing (AdamTs1, FN, Icam1, Lamb1, Plat, Plaur). The data suggest that the genes expressed at higher levels in the IB4- neurons could contribute to the initial growth response of these cells in a permissive environment and could also represent a common injury response that subsequently promotes axon regeneration. The differential expression of several extracellular matrix molecules (FN, Lamb1, Icam) may suggest that the IB4- neurons are capable of maintaining /secreting their local extracellular environment which could aid in the regenerative process. Overall, these data provide new information on potential targets that could be manipulated to enhance axonal regeneration in the mature nervous system.
Extracellular Matrix Marker of Arrhythmia Risk (EMMA)
ClinicalTrials.gov study NCT00376532. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Extracellular matrix-associated gene expression in adult sensory neurons cultured on laminin substrates
Open the record for dataset details and reuse information.
Modulating the Extracellular Matrix to Treat Wound Healing Defects in Ehlers-Danlos Syndrome
GEO Series GSE264169. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing.
Activation of adult human pancreatic ductal and ductal progenitor-like cells requires extracellular matrix protein signaling [scRNA-seq]
GEO Series GSE233785. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
GEO Series GSE33581. Homo sapiens. 3 samples. Type: Expression profiling by RT-PCR.
Three Distinct Cell Types Express Extracellular Matrix Proteins In Different Niches During Skeletal Muscle Fibrosis
GEO Series GSE89633. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Chemotherapy-induced extracellular matrix remodelling in HGSOC
GEO Series GSE270878. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell Transcriptomics Shows Cellular Heterogeneity, Intercellular Communication, and Extracellular Matrix Remodeling in Corneal Fibrosis In Vivo
GEO Series GSE302936. Oryctolagus cuniculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Starvation induced circulating miR-33a secretion remodeled extracellular matrix of tumor microenvironment by altering polyamine metabolism [miRNA-Seq]
GEO Series GSE222293. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer [DNA-seq]
GEO Series GSE209951. Homo sapiens. 52 samples. Type: Other.
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling
GEO Series GSE288213. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
The secreted protease Adamts18 links mammary epithelial hormone action to extracellular matrix changes and stem cell niche function
GEO Series GSE145680. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Systems biology of gene expression of bladder papilloma cells modulated by a malignant-derived extracellular matrix
GEO Series GSE9291. Homo sapiens. 11 samples. Type: Expression profiling by array.
Loss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.
GEO Series GSE276991. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Basonuclin-2 regulates extracellular matrix production and degradation
GEO Series GSE221228. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
H3K27me3Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3 [RNA-Seq]
GEO Series GSE316449. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.