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ShareScore release 0.9.0
Dataset results
50 results for “gene conversion”
NGLY1-dependent conversion of N-glycosylated N to D is essential for transcription of proteasome genes
GEO Series GSE301626. Homo sapiens. 9 samples. Type: Expression profiling by array.
Gene expression in macrophages derived form wild-type and Ndfst1-deficient mice before and after foam cell conversion
GEO Series GSE51009. Mus musculus. 16 samples. Type: Expression profiling by array.
Conversion of human fibroblasts into vascular cells (gene expression)
GEO Series GSE40793. Homo sapiens. 25 samples. Type: Expression profiling by array.
Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules [gene expression]
GEO Series GSE58557. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression analysis of human embryonic stem cells, fibroblast iPSC, and low passage stromal primed myeloid iPSC before and after conversion to the naïve state
GEO Series GSE65211. Homo sapiens. 24 samples. Type: Expression profiling by array.
Fate Erasure Logic of Gene Networks Underlying Direct Neuronal Conversion of Somatic Cells by MicroRNAs II
GEO Series GSE283006. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Fate Erasure Logic of Gene Networks Underlying Direct Neuronal Conversion of Somatic Cells by MicroRNAs I
GEO Series GSE283004. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
MYOD Gene Expression Regulation during Myogenic Conversion of Fibroblasts
GEO Series GSE98198. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Data from: Contrasting evolutionary histories of MHC class I and class II loci in grouse - effects of selection and gene conversion
Genes of the major histocompatibility complex (MHC) encode receptor molecules that are responsible for recognition of intra- and extra-cellular pathogens (class I and class II genes, respectively) in vertebrates. Given the different roles of class I and II MHC genes, one might expect the strength of selection to differ between these two classes. Different selective pressures may also promote different rates of gene conversion at each class. Despite these predictions, surprisingly few studies have looked at differences between class I and II genes in terms of both selection and gene conversion. Here, we investigated the molecular evolution of MHC class I and II genes in five closely related species of prairie grouse (Centrocercus and Tympanuchus) that possess one class I and two class II loci. We found striking differences in the strength of balancing selection acting on MHC class I versus class II genes. More than half of the putative antigen-binding sites (ABS) of class II were under positive or episodic diversifying selection, compared with only 10% at class I. We also found that gene conversion played a stronger role in shaping the evolution of MHC class II than class I. Overall, the combination of strong positive (balancing) selection and frequent gene conversion has maintained higher diversity of MHC class II than class I in prairie grouse. This is one of the first studies clearly demonstrating that macroevolutionary mechanisms can act differently on genes involved in the immune response against intra- and extra-cellular pathogens.
First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury
ClinicalTrials.gov study NCT06922890. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploratory Study on Combined Conversion Immunotherapy for Liver Metastasis of MSS Type Initial Unresectable Colorectal Cancer Based on Gene Status
ClinicalTrials.gov study NCT05409417. IPD Sharing: YES. Countries: 1. Publications: 0.
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells following transient naive genes activation.
GEO Series GSE184562. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing.
Data from: Contrasting evolutionary histories of MHC class I and class II loci in grouse - effects of selection and gene conversion
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Data from: Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements
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Data from: Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences
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Gene expression profiles of BrdU-treated BE(2)N during conversion from adrenergic to mesenchymal cell lineages
GEO Series GSE171379. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Fate Erasure Logic of Gene Networks Underlying Direct Neuronal Conversion of Somatic Cells by MicroRNAs
GEO Series GSE283010. Homo sapiens. 66 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Mutation of the RNA polymerase β-subunit gene promotes hetero-to-homo conversion of ß-lactam resistance of methicillin-resistant Staphylococcus aureus
GEO Series GSE42218. Staphylococcus aureus. 2 samples. Type: Expression profiling by array.
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner
GEO Series GSE240860. Mus musculus. 54 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner [ATAC-Seq]
GEO Series GSE240782. Mus musculus. 25 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.