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412
datasets available to search
ShareScore release 0.7.1
Dataset results
412 results for “genetic risk”
Genetic Risk Assessment for Cancer Education and Empowerment (GRACE) Project
ClinicalTrials.gov study NCT03326713. IPD Sharing: NO. Countries: 1. Publications: 5.
Association of Host Genetics With Vaccine Efficacy and Study of Immune Correlates of Risk From a Tetravalent Dengue Vaccine
ClinicalTrials.gov study NCT02827162. IPD Sharing: YES. Countries: 1. Publications: 2.
Early Detection of GEnetic Risk (EDGE)
ClinicalTrials.gov study NCT04746794. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
ClinicalTrials.gov study NCT02525939. IPD Sharing: NO. Countries: 32. Publications: 3.
Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease
ClinicalTrials.gov study NCT01884545. IPD Sharing: Not stated. Countries: 1. Publications: 9.
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
ClinicalTrials.gov study NCT05926102. IPD Sharing: YES. Countries: 1. Publications: 1.
Genetically Engineered Lymphocyte Therapy After Peripheral Blood Stem Cell Transplant in Treating Patients With High-Risk, Intermediate-Grade, B-cell Non-Hodgkin Lymphoma
ClinicalTrials.gov study NCT01318317. IPD Sharing: Not stated. Countries: 1. Publications: 2.
GENetic Education Risk Assessment and TEsting Study
ClinicalTrials.gov study NCT03762590. IPD Sharing: NO. Countries: 1. Publications: 1.
Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans
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Data from: Evaluating inbreeding and assessing the risk of outbreeding depression in genetic rescue of the endangered marsh fritillary (<em>Euphydryas aurinia</em>)
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Demography and environment modulate the effects of genetic diversity on extinction risk in a butterfly metapopulation
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Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse
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Data from: Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population
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Data from: Combining spatial, genetic, and environmental risk data to define and prioritize in situ conservation units
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Data from: Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population
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Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS, and impact on esophageal cancer risk in Japanese people
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Data from: Populations at risk: conservation genetics of kangaroo mice (Microdipodops) of the Great Basin Desert
The Great Basin Desert of western North America has experienced frequent habitat alterations due to a complex biogeographic history and recent anthropogenic impacts, with the more recent alterations likely resulting in the decline of native fauna and flora. Dark (Microdipodops megacephalus) and pallid (M. pallidus) kangaroo mice are ecological specialists found within the Great Basin Desert and are potentially ideal organisms for assessing ecosystem health and inferring the biogeographic history of this vulnerable region. Herein, newly acquired nuclear-encoded microsatellite loci were utilized to assess patterns of variation within and among spatially discrete groups of kangaroo mice and to evaluate gene flow, demographic trends, and genetic integrity. Results confirm that there are at least three genetically distinct units within M. megacephalus and two such units within M. pallidus. The three units of M. megacephalus appear to have different demographic histories, with effectively no gene flow among them since their divergence. Similarly, the two units of M. pallidus also appear to have experienced different demographic histories, with effectively no gene exchange. Contemporary effective population sizes of all groups within Microdipodops appear to be low (<500), suggesting that each genetic lineage may have difficulty coping with changing environmental pressures and hence may be at risk of extirpation. Results of this study indicate that each Microdipodops group should be recognized, and therefore managed, as a separate unit in an effort to conserve these highly specialized taxa that contribute to the diversity of the Great Basin Desert ecosystem.
Data from: Association mapping of genetic risk factors for chronic wasting disease in wild deer
Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy affecting North American cervids. We assessed the feasibility of association mapping CWD genetic risk factors in wild white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) using a panel of bovine microsatellite markers from three homologous deer linkage groups predicted to contain candidate genes. These markers had a low cross-species amplification rate (27.9%) and showed weak linkage disequilibrium (<1 cM). Markers near the prion protein and the neurofibromin 1 (NF1) genes were suggestively associated with CWD status in white-tailed deer (P = 0.006) and mule deer (P = 0.02), respectively. This is the first time an association between the NF1 region and CWD has been reported.
Data from: The effect of sex-biased dispersal on opposite-sexed spatial genetic structure and inbreeding risk
Natal sex-biased dispersal has long been thought to reduce the risk of inbreeding by spatially separating opposite-sexed kin. Yet, comprehensive and quantitative evaluations of this hypothesis are lacking. In this study, we quantified the effectiveness of sex-biased dispersal as an inbreeding avoidance strategy by combining spatially explicit simulations and empirical data. We quantified the extent of kin clustering by measuring the degree of spatial autocorrelation among opposite-sexed individuals (FM structure). This allowed us to systematically explore how the extent of sex-biased dispersal, generational overlap, and mate searching distance, influenced both kin clustering, and the resulting inbreeding in the absence of complementary inbreeding avoidance strategies. Simulations revealed that when sex-biased dispersal was limited, positive FM genetic structure developed quickly and increased as the mate searching distance decreased or as generational overlap increased. Interestingly, complete long-range sex-biased dispersal did not prevent the development of FM genetic structure when generations overlapped. We found a very strong correlation between FM genetic structure and both FIS under random mating, and pedigree-based measures of inbreeding. Thus, we show that the detection of FM genetic structure can be a strong indicator of inbreeding risk. Empirical data for two species with different life history strategies yielded patterns congruent with our simulations. Our study illustrates a new application of spatial genetic autocorrelation analysis that offers a framework for quantifying the risk of inbreeding that is easily extendable to other species. Furthermore, our findings provide other researchers with a context for interpreting observed patterns of opposite-sexed spatial genetic structure.
Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population
<p>QuantStudio 12K Flex (Life Technologies) raw data files</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.