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76 results for “guinea pigs”
Reproduction affects immune defenses in the guinea pig even under ad libitum food
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Data from: The way wear goes – phytolith-based wear on the dentine-enamel system in guinea pigs (Cavia porcellus)
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Figure 5 from: Kadinov B, Itzev D (2020) Influence between NO and CO in guinea pig stomach fundus. Pharmacia 67(3): 161-168. https://doi.org/10.3897/pharmacia.67.e52474
Figure 5 FES-evoked relaxations in non-treated and treated guinea pigs in presence of VitE (100 µmol L-1). (a) Effect of Hemin (10 µmol L-1) on 2 Hz (n = 5) evoked relaxations. (b) Effect of Hemin (10 µmol L-1) on 5 Hz (n = 5) induced relaxatory responses of the strips. Data are the means ±SEM of experiments (* p < 0.5).
Figure 3 from: Kadinov B, Itzev D (2020) Influence between NO and CO in guinea pig stomach fundus. Pharmacia 67(3): 161-168. https://doi.org/10.3897/pharmacia.67.e52474
Figure 3 (a) Original trace representing the effect of hemin (0.01 µmol.L-1) on the FES-evoked relaxation in non-treated guinea-pig gastric fundus strips. (b) Original trace representing the effect of hemin (0.01 µmol.L-1) on the FES-evoked relaxation in treated guinea-pig gastric fundus strips. – adding PgF2α (0.5 ηmol.L-1) to evoke contractile response. Incubation with hemin is for 20 min., with Vitamin E – 10 min. before hemin application. The responses of the strips to EFS were registered in the presence of atropine (1 µmol.L-1).
Figure 4 from: Kadinov B, Itzev D (2020) Influence between NO and CO in guinea pig stomach fundus. Pharmacia 67(3): 161-168. https://doi.org/10.3897/pharmacia.67.e52474
Figure 4 FES-evoked relaxations in non-treated and treated guinea pigs. (a) Effect of Hemin (10 µmol.L-1) on 2 Hz (n = 5) evoked relaxations. (b) Effect of Hemin (10 µmol.L-1) on 5 Hz (n = 5) induced relaxatory responses of the strips. Data are the means ±SEM of experiments (* p < 0.5).
Figure 2 from: Kadinov B, Itzev D (2020) Influence between NO and CO in guinea pig stomach fundus. Pharmacia 67(3): 161-168. https://doi.org/10.3897/pharmacia.67.e52474
Figure 2 Immunohistochemistry of HO-1 and HO-2. Immunohistochemically stained 30 µm thick sections of the guinea pig stomach fundus for non-treated and treated animals.
Data from: Paternal intergenerational epigenetic response to heat exposure in male Wild guinea pigs
Epigenetic modifications, of which DNA methylation is the best studied one, can convey environmental information through generations via parental germ lines. Past studies have focused on the maternal transmission of epigenetic information to the offspring of isogenic mice and rats in response to external changes, whereas heterogeneous wild mammals as well as paternal epigenetic effects have been widely neglected. In most wild mammal species, males are the dispersing sex and have to cope with differing habitats and thermal changes. As temperature is a major environmental factor we investigated if genetically heterogeneous Wild guinea pig (Cavia aperea) males can adapt epigenetically to an increase in temperature and if that response will be transmitted to the next generation(s). Five adult male guinea pigs (F0) were exposed to an increased ambient temperature for 2 months, i.e. the duration of spermatogenesis. We studied the liver (as the main thermoregulatory organ) of F0 fathers and F1 sons, and testes of F1 sons for paternal transmission of epigenetic modifications across generation(s). Reduced representation bisulphite sequencing revealed shared differentially methylated regions in annotated areas between F0 livers before and after heat treatment, and their sons' livers and testes, which indicated a general response with ecological relevance. Thus, paternal exposure to a temporally limited increased ambient temperature led to an 'immediate' and 'heritable' epigenetic response that may even be transmitted to the F2 generation. In the context of globally rising temperatures epigenetic mechanisms may become increasingly relevant for the survival of species.
Data from: Paternal intergenerational epigenetic response to heat exposure in male Wild guinea pigs
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Data from: Diet changes alter paternally inherited epigenetic pattern in male Wild guinea pigs
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In vivo transcriptomic responses to thioacetamide exposure in guinea pig liver tissue
GEO Series GSE169545. Cavia porcellus. 30 samples. Type: Expression profiling by high throughput sequencing.
Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vitro]
GEO Series GSE226311. Cavia porcellus. 30 samples. Type: Expression profiling by high throughput sequencing.
Development of a novel guinea pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high-fat diet.
GEO Series GSE244302. Cavia porcellus. 24 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic atlases of midgestation fetal-maternal interface from opossum, tenrec, guinea pig, and mouse
GEO Series GSE274701. Tenrec ecaudatus; Mus musculus; Monodelphis domestica; Cavia porcellus. 23 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling of guinea pig whole-lung and hindlimb muscles following long-term exposure to cigarette smoke and/or hypoxia
GEO Series GSE51601. Cavia porcellus. 45 samples. Type: Expression profiling by array.
Next Generation Sequencing Facilitates Quantitative Analysis of Mock/ZIKV infected Guinea Pig Lung Transcriptomes
GEO Series GSE210370. Cavia porcellus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Guinea Pig Serves as an Alternative Model to Study Human Preimplantation Development
GEO Series GSE253670. Cavia porcellus. 661 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and Proteomic Analyses of Sclera in Lens-Induced Myopic Guinea Pigs
GEO Series GSE280609. Cavia porcellus. 10 samples. Type: Expression profiling by high throughput sequencing.
DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life
GEO Series GSE163447. Cavia porcellus. 24 samples. Type: Methylation profiling by high throughput sequencing.
Transcriptomic profiling of guinea pigs with NASH and advanced fibrosis
GEO Series GSE158168. Cavia porcellus. 12 samples. Type: Expression profiling by high throughput sequencing.
Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vivo]
GEO Series GSE226312. Cavia porcellus. 30 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.