Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
24
datasets available to search
ShareScore release 0.9.0
Dataset results
24 results for “homozygosity”
Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization.
ClinicalTrials.gov study NCT01541813. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity
ClinicalTrials.gov study NCT02619955. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Homozygosity mapping in family segregating premature ovarian insufficiency (POI)
GEO Series GSE56043. Homo sapiens. 8 samples. Type: SNP genotyping by SNP array.
Genome-wide Characterization of Selection Signatures and Runs of Homozygosity in Ugandan Goat Breeds
<p><strong>ABSTRACT</strong></p> <p>Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in regions associated with traits under intense selection pressure. In this study, we evaluated selection signatures and genomic inbreeding coefficients, based on runs of homozygosity (ROH), in six Ugandan goat breeds: Boer (n = 13), and the indigenous breeds Karamojong (n = 15), Kigezi (n = 29), Mubende (n = 29), Small East African (n = 29) and Sebei (n = 29). After genotyping quality control, 45,294 autosomal single nucleotide polymorphisms (SNPs) remained for further analyses. A total of 394 and 6 breed-specific putative selection signatures were identified across all breeds, based on the fixation index ( -values) and hapFLK statistics respectively. These regions were enriched with genes involved in signalling pathways associated directly or indirectly with environmental adaptation, such as immune response (e.g. <em>IL10RB</em> and <em>IL23A</em>), growth and fatty acid composition (e.g. <em>FGF9</em> and <em>IGF1</em>), and thermo-tolerance (e.g. <em>MTOR</em> and <em>MAPK3</em>). The study revealed little overlap in genomic regions under selection and generally did not display the typical classic selection signatures as expected due to the complex nature of the traits. In the Boer breed, candidate genes associated with production traits, such as body size and growth (e.g. <em>GJB2</em> and <em>GJA3</em>) were also identified. Furthermore, analysis of ROH in indigenous goat breeds showed very low levels of genomic inbreeding (with the mean per breed ranging from 0.8% to 2.4%), as compared to higher inbreeding in Boer (mean = 13.8%). And, short ROH were more frequent than long ROH, except in Karamojong, providing insight in the developmental history of these goat breeds. This study provides important insights into the effects of long-term selection in Boer and indigenous Ugandan goat breeds and its genetic. Our findings are of great relevance to the implementation of breeding programs and conservation of genetic resources, as well as their sustainable use and management.</p> <p> </p> <p> </p> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.