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8,060 results for “injury”
Head and dental injuries among farriers and hoof care practitioners: a nationwide survey in Switzerland (dataset)
<p>(1) Data on occupational head/face and dental injuries gathered in a questionnaire-based, voluntary survey, which was mailed to farriers and hoof care practitioners in Switzerland.</p> <p>(2) Data of the Swiss National Accident Insurance Fund on recognized occupational injuries of farriers in the time window 2015-2019 (Klasse 11c AOK, DM03, Ergebnisse aus dem Versicherungsbetrieb der Suva, VTS-ID 25268 2020). </p>
Figure 2 in Economic injury level of date spider mite, Oligonychus afrasiaticus (Acari: Tetranychidae) on six commercial date cultivars
Figure 2. Regression between mite-day as an independent variable and fruits injury rate as a dependent variable in the different date cultivars studied in 2018.
Diet-microbiome interactions following spinal cord injury in mice
<p>Here, we performed 16S (V3-V4) rRNA sequencing of the stool microbiome in mice following spinal cord injury, with or without a dietary fiber intervention. Provided here are two .zip files containing the downstream analyses of two independent cohorts (both experimentally and in sequencing/analysis), as performed by Zymo, Inc through their Microbiomics platform. Each .zip file contains a "Report" HTML file which summarizes key findings. All underlying data for each analysis are included in sub folders, inclusive of taxonomic composition and various diversity measurements. Sequences used in these analyses have been deposited into the NCBI SRA database under accession #PRJNA1119045.</p>
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data
<p><span>This repository provides datasets for the study: https://broad.io/DILIPredictor</span></p> <p><span>Full Paper: https://www.biorxiv.org/content/10.1101/2024.01.10.575128v1</span></p> <p><span>This work is on enhancing the early detection of Drug-Induced Liver Injury (DILI) through the integration of predicted in vivo and in vitro data. This project utilizes advanced machine learning models and chemical informatics to predict the likelihood of DILI for various compounds. </span></p> <p><span>For code see: <a href="https://github.com/srijitseal/DILI">https://github.com/srijitseal/DILI</a><br><br>Drug-induced liver injury (DILI) has been significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals. The existing suite of in vitro proxy-DILI assays is generally effective at identifying compounds with hepatotoxicity. However, there is considerable interest in enhancing in silico prediction of DILI because it allows for the evaluation of large sets of compounds more quickly and cost-effectively, particularly in the early stages of projects. In this study, we aim to study ML models for DILI prediction that first predicts nine proxy-DILI labels and then uses them as features in addition to chemical structural features to predict DILI. The features include <em>in vitro</em> (e.g., mitochondrial toxicity, bile salt export pump inhibition) data, <em>in vivo</em> (e.g., preclinical rat hepatotoxicity studies) data, pharmacokinetic parameters of maximum concentration, structural fingerprints, and physicochemical parameters. We trained DILI-prediction models on 888 compounds from the DILIst dataset and tested on a held-out external test set of 223 compounds from DILIst dataset. The best model, DILIPredictor, attained an AUC-ROC of 0.79. This model enabled the detection of top 25 toxic compounds compared to models using only structural features (2.68 LR+ score). Using feature interpretation from DILIPredictor, we were able to identify the chemical substructures causing DILI as well as differentiate cases DILI is caused by compounds in animals but not in humans. For example, DILIPredictor correctly recognized 2-butoxyethanol as non-toxic in humans despite its hepatotoxicity in mice models. Overall, the DILIPredictor model improves the detection of compounds causing DILI with an improved differentiation between animal and human sensitivity as well as the potential for mechanism evaluation. DILIPredictor is publicly available at </span><a href="https://broad.io/DILIPredictor">https://broad.io/DILIPredictor</a> <span>for use <em>via</em> web interface and with all code available for download and local implementation via </span><a href="https://pypi.org/project/dilipred/"><span>https://pypi.org/project/dilipred/</span></a><span>.</span></p>
Figure 6 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 6. Graphical representation of Glutathione (ΜM) in the seven days after injury in G1-Control, G2-Dip, and G3-Free AA. G2-Dip presented a larger amount concerning the G1-Control *(P<0.05).
Figure 4 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 4. Graphical representation of interspace (stasis) regions length (mm) in the seven days after injury in G1-Control,G2-Dip, and G3-FreeAA.G1-Control presented smaller interspaces in 666 relation to the treated groups G2-Dip (P<0.01) and G3-FreeAA *(P<0.01).
Figure 5 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 5. Graphical representation of fibroblast counts in three fields of the interspace dermis among in the seven days after injury in G1-Control, G2-Dip, and G3-FreeAA. G1-Control presented less amount of fibroblast concerning the treated groups G2-Dip (P<0.01) and G3-Free AA *(P<0.01).
Figure 3 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 3. Histopathology study of the necrotic areas: (A) Photomicrograph of G2-Dip animal, with necrosis presence in the dermis (superior arrows) just below the epidermis (E) and in the hypodermis (arrows below in the right). Hair follicle (HF). Masson's trichrome; 100x; (B) Photomicrograph of G1-Control animal, hemorrhagic foci are observed in both dermis and hypodermis (arrows). Central blood vessel (BV). Masson's trichrome; 400x; (C) Photomicrograph of G3-FreeAA animal, with a large area of edema in both dermis and hypodermis (arrows). Hair follicle (HF). Masson's trichrome; 100x; (D) Photomicrograph of G1-Control animal: hemorrhagic focus can be observed in the hypodermis and many neutrophils (minor arrows) in a blood vessel (BV) lumen, some in diapedesis through its wall (larger arrow). The thinner arrows show a small intercellular inflammatory infiltrate. Giemsa; 400x.
Figure 2 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 2. Graphical representation of necrosis percentage evolution obtained by photographic analysis in the burn interspace, two and seven days after injury in G1-Control, G2-Dip and G3-FreeAA. In the G3-FreeAA there was a significant reduction of necrosis between two and seven days *(P<0.05).
Figure 1 in Oral glutamine dipeptide or oral glutamine free amino acid reduces burned injury progression in rats
Figure 1. Rat comb burn model: (A) Comb metal plate; (B) Comb burn injury, with four rectangular full-thickness burn areas separated by three unburned interspaces (stasis zone); (C) rectangular burned full thickness areas just after the injury; (D) animal from treated group 7 days after injury showing interspaces (stasis zone) without necrosis.
Unveiling Pathophysiological Insights: Serum Metabolic Dysregulation in Acute Respiratory Distress Syndrome Patients with Acute Kidney Injury
<p>The uploaded data is an Excel sheet obtained after performing the binning of 1H CPMG NMR spectra acquired using 800 MHz NMR on the serum samples of ARDS patients and ARDS with AKI patients. </p>
Fig. 1 in First report of economic injury to tomato due to Zeugodacus tau (Diptera: Tephritidae): relative abundance and effects of cultivar and season on injury
Fig. 1. Seasonal pattern of Zeugodacus tau male adults (mean ± SE) captured by Cue-lure-based traps in tomato in (a) season 1, and (b) season 2.
Supplemental Figure 1 for Macrophage Secreted TGF-β1 Contributes to Fibroblast Activation and Ureteral Stricture Following Ablation Injury
<p>Supplemental Figure 1. TGF-β1 (brown) and Masson Trichrome (blue) staining of healthy ureteral wall adjacent to the site of IRE treatment. A-D) Sparse numbers of spindle shaped cells (fibroblasts, arrows) can be seen in healthy ureter adjacent to IRE treated ureter but their numbers were not different from what was observed in untreated control ureter. F-H) Ureteral wall adjacent to the site of IRE treatment stains positive for collagen (blue) but the levels remain invariant through different timepoints. The muscularis (asterisk) of the ureteral wall is preserved, with no evidence of scarring.</p>
Attempted Arm and Hand Movements can be Decoded from Low-Frequency EEG from Persons with Spinal Cord Injury
<p>We show that persons with spinal cord injury (SCI) retain decodable neural correlates of attempted arm and hand movements. We investigated hand open, palmar grasp, lateral grasp, pronation, and supination in 10 persons with cervical SCI. Discriminative movement information was provided by the time-domain of low-frequency electroencephalography (EEG) signals. Based on these signals, we obtained a maximum average classification accuracy of 45% (chance level was 20%) with respect to the five investigated classes. Pattern analysis indicates central motor areas as the origin of the discriminative signals. Furthermore, we introduce a proof-of-concept to classify movement attempts online in a closed loop, and tested it on a person with cervical SCI. We achieved here a modest classification performance of 68.4% with respect to palmar grasp vs hand open (chance level 50%).</p>
Figure 2 in New record of Microtechnites bractatus (Say) (Hemiptera: Miridae) infesting Crotalaria spp. and injuries of Miridae in cultivated plants in the State of Paraná, Brazil
Figure 2 Damage of (A) Microtechnites bractatus and (B) Collaria scenica in black oats (Avena strigosa), ryegrass (Lolium multiflorum), beans (Phaseolus vulgaris), white clover (Trifolium repens), tifton 85 (Cynodon spp.), fescue (Festuca sp.), corn (Zea mays) and (viii) crotalaria (Crotalaria juncea).
Fig. 3 in Record of postmortem injuries caused by the Neotropical social wasp Agelaia fulvofasciata (Degeer) (Hymenoptera, Vespidae) on pig carcasses in the Eastern Amazon region: implications in forensic taphonomy
Fig. 3. Arrow pointing postmortem injuries (artifacts) produced by biotaphonomic activity of Agelaia fulvofasciata.
Figure 4 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 4. Morphology and location of PAS granules of brain tissues of control (A), Hyp-treated (B), Ni-treated (C), and Ni + Hyp-treated (D) rats. Homogeneous PAS staining was observed in the control group (A) and the Hyp-treated (B) groups. Clusters of granules shown inside square (C) and by black arrow (D), respectively (200× magnification).
Figure 3 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 3. Histological views of brain tissues of control (A), Hyp-treated (B), Ni-treated (C), and Ni + Hyp-treated (D) rats. Small blood vessels (BV) from pia mater penetrate the cerebral cortex substance pyramidal cells (PC) with apical dendrites closely associated with smaller, round glial cells (GC) (A and B). Perivascular inflammation around a blood vessel (inside square) (C) and perivascular inflammatory cell infiltrates in hematoxylin and eosin-stained brain tissue (D) (200× magnification).
Figure 5 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 5. Brain tissues of control (A) and Hyp (B) groups were negative for Congo red. Amyloid deposits in brain parenchyma and around blood vessels shown inside square (C) and marked by black arrows (D) (200× magnification). Differences in measured parameters among the groups were analyzed with a nonparametric test (Kruskal–Wallis). Dual comparisons between groups exhibiting significant values were evaluated with a Mann–Whitney U test (P <0.05).
Figure 1 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 1. Effect of Ni administration on body weight gain. Data are presented as mean ± standard error of mean (SEM) (n = 7). a Significant differences between other studied groups and control (a4 P <0.0001). b Significant differences between other groups studied and Hyp group (b1 P <0.05, b4 P <0.0001). c Significant differences between other groups studied and Ni + Hyp group (c3 P <0.001) by Tukey's multiple range tests.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.