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108 results for “ion channel”
Touch sensation requires the mechanically gated ion channel ELKIN1
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Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
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The ion channel mechanisms of the subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the depression-like behavior
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Functionally-coupled ion channels begin co-assembling at the start of their synthesis
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Data from: Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
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Data from: Towards high-resolution modeling of small molecule - ion channel interactions
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Data from: Remote neurostimulation through an endogenous ion channel using a near infrared light-activatable nanoagonist
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Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold
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Data from: A functionally conserved mechanism of modulation via a vestibule site in pentameric ligand-gated ion channels
<p>Pentameric ligand-gated ion channels (pLGICs) belong to a class of ion channels involved in fast synaptic signaling in the central and peripheral nervous systems. Molecules acting as allosteric modulators target binding sites that are remote from the neurotransmitter binding site, but functionally affect coupling of ligand binding to channel opening. Here, we investigated an allosteric binding site in the ion channel vestibule, which has converged from a series of studies on prokaryote and eukaryote channel homologs. We discovered single domain antibodies, called nanobodies, which are functionally active as allosteric modulators, and solved co-crystal structures of the prokaryote channel ELIC bound either to a positive (PAM) or a negative (NAM) allosteric modulator. We extrapolate the functional importance of the vestibule binding site to eukaryote ion channels, suggesting a conserved mechanism of allosteric modulation. This work identifies key elements of allosteric binding sites and extends drug design possibilities in pLGICs using nanobodies.</p>
Molecular dynamics simulation of a pentameric ligand-gated ion channel DeCLIC
<p>Molecular dynamics simulation trajectories, parameter files for a bacterial pentameric ligand-gated ion channel DeCLIC, in the system with 150mM CaCl2 or NaCl2.</p>
Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions
<p>Peer-reviewed manuscript, supplemental file, and source data related to the article 'Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions'.</p>
Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"
<p>Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"</p>
Data from Selectivity filter mutations shift ion permeation mechanism in potassium channels
<p>Example mdp, gro files, topologies, scripts, run input files and trajectories used in https://doi.org/10.1101/2023.04.17.537168</p>
data for "Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel"
<p>Data S1 for Manuscript <strong>Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel.</strong></p>
Input files for the simulation of KcsA-K+-LAB-TEA, when LAB-TEA is placed in the cytoplasmic region with K+-ion in the channel cavity
<p>Input files for the simulation of KcsA-K<sup>+</sup>-LAB-TEA, when LAB-TEA is placed in the cytoplasmic region with K<sup>+</sup>-ion in the channel cavity. The inputs include,<br> 1. Input files for minimization (*min.in)<br> 2. Input files for heating (*h1.in, *h2.in, and *h3.in)<br> 3. Input files for equilibration (*eq*.in) and production runs (*prd*.in)<br> 4. Input files for the first trajectories start with file name, 1-lab-tea-k-entra*<br> 5. Input files for the remaining different trajectories start with file name, lab-tea-k-entra*<br> 6. Input files for the trajectories with restraint weight on K<sup>+</sup>-ion starting with file name, lab-tea-entra-k-restraint*</p>
Input files for the simulation of KcsA-LAB-TEA, when LAB-TEA is placed in the channel cavity with no K+-ion
<p>Input files for the simulation of KcsA-LAB-TEA, when LAB-TEA is placed in the channel cavity. The simulation is performed without K<sup>+</sup>-ion. The inputs include,<br> 1. Input files for minimization (*min.in)<br> 2. Input files for heating (*h1.in, *h2.in, and *h3.in)<br> 3. Input files for equilibration (*eq*.in) and production runs (*prd*.in)<br> 4. Input files for the first trajectories start with file name, 1-lab-tea*<br> 5. Input files for the remaining different trajectories start with file name, lab-tea*</p>
Input files for the simulation of KcsA-K+-LAB-TEA, when both LAB-TEA and K+-ion are placed inside the channel cavity.
<p>Input files for the simulation of KcsA-K<sup>+</sup>-LAB-TEA, when both LAB-TEA and K+-ion are placed inside the channel cavity. The inputs include,<br> 1. Input files for minimization (*min.in)<br> 2. Input files for heating (*h1.in, *h2.in, and *h3.in)<br> 3. Input files for equilibration (*eq*.in) and production runs (*prd*.in)<br> 4. Input files for the first trajectories start with file name, 1-lab-tea-k<sup>+</sup>*<br> 5. Input files for the remaining different trajectories start with the file name, lab-tea-k<sup>+</sup>*</p>
Parameters for the solvated KcsA-LAB-TEA, when the LAB-TEA is placed inside the channel cavity without K+-ion
<p>Parameters for the solvated KcsA-LAB-TEA. These KcsA-LAB-TEA systems were solvated by truncated octahedron TIP3PBOX, using the leap program in AMBER20. The LAB-TEA is placed inside the channel cavity. The simulation is performed without K<sup>+</sup>-ion.</p>
Parameters for the solvated KcsA-K+-LAB-TEA, when both LAB-TEA and K+-ion placed inside the channel cavity
<p>Parameters for the solvated KcsA-K<sup>+</sup>-LAB-TEA. These KcsA-K<sup>+</sup>-LAB-TEA systems were solvated by truncated octahedron TIP3PBOX, using the leap program in AMBER20. Both LAB-TEA and K<sup>+</sup>-ion are placed inside the channel cavity.</p>
Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura
ClinicalTrials.gov study NCT04063540. IPD Sharing: NO. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.