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539 results for “loss of function.”
Data for: Elevated inbreeding in Heliconia tortuosa is determined by tropical forest stand age, isolation, and loss of hummingbird functional diversity
<p>Forest conversion and habitat loss are major threats to biological diversity. Forest regeneration can mitigate the negative effects of old growth forest loss on species diversity, but less is known about the extent to which forest loss reduces genetic diversity in remnant populations and whether secondary forests play a role in the maintenance of genetic diversity. We quantified genetic diversity in a tropical hummingbird-pollinated understory herb, <em>Heliconia tortuosa</em>, across a landscape mosaic of primary and secondary forest regrowth. Using microsatellite genotypes from >850 adult and juvenile plants within 33 forest patches and extensive bird surveys, we examined the effect of contemporary and historical landscape features including forest age (primary vs. secondary forest), stand isolation, and pollinator assemblages on genetic diversity and levels of inbreeding in <em>H. tortuosa</em>. We found that inbreeding was up to 3x higher in secondary forest, and this effect was amplified with reductions in primary forest in the surrounding landscape through reduced observed heterozygosity in isolated fragments. Inbreeding in forest patches was negatively correlated with the local frequency of specialist long-distance foraging traplining hummingbirds. Traplining hummingbirds therefore appear to facilitate mating among unrelated plants - an inference we tested using empirically parameterized simulations. Higher levels of inbreeding in <em>H. tortuosa</em> are therefore associated with reduced functional diversity of hummingbirds in secondary forests and forest patches isolated from primary forests. Our findings suggest a cryptic consequence of primary forest loss and secondary forest regeneration through the disruption of mutualistic interactions resulting in the erosion of genetic diversity in a common understory plant.</p>
Afforestation and abandonment of semi-natural grasslands lead to biodiversity loss and a decline in ecosystem services and functions
<p>1. During the past century, semi-natural grasslands, once widespread throughout Europe, have largely been converted into intensively managed agricultural areas, abandoned or afforested. These large-scale land-use changes have already resulted in considerable biodiversity loss but can also lead to a decline in ecosystem service provision and ecosystem multifunctionality.</p> <p>2. We assessed the impact of afforestation and abandonment of semi-natural grasslands on the supply of ecosystem services in Western Estonia. We compared a wide array of services provided by open grasslands, abandoned grasslands, and afforested grasslands. Additionally, we analysed the impact of land-use change and species richness on ecosystem multifunctionality.</p> <p>3. Significant declines in the supply of pollination service, natural pest regulation, forage production, soil quality, wild food, and cultural appreciation of landscape were detected as a result of overgrowing or afforestation.</p> <p>4. There was a significant positive relationship between species richness and ecosystem multifunctionality, i.e. more biodiverse grasslands were able to support more services at a higher capacity.</p> <p>5. Results show that both grassland degradation due to abandonment, as well as grassland afforestation, have significant negative impacts on biodiversity, on the supply of multiple important ecosystem services and on the ecosystem multifunctionality.</p> <p>6. Synthesis and applications. Temperate semi-natural grasslands have high biodiversity and capacity to deliver multiple important ecosystem services simultaneously. Conservation and restoration of grassland habitats must be considered as an important part of sustainable landscape planning.</p>
Data: Multilayer integration in silicon nitride: decoupling linear and nonlinear functionalities for ultralow loss photonic integrated systems
<p>This folder contains the data relative to the paper with title:<br> Multilayer integration in silicon nitride: decoupling linear and nonlinear functionalities for ultralow loss photonic integrated systems<br> by<br> Marcello Girardi, Óskar Helgason, Alexander Caut, Magnus Karlsson, Anders Larsson, Victor Torres Company</p> <p>Chalmers University of Technology</p>
Does Glaucoma Cause Loss of Brain Function?
ClinicalTrials.gov study NCT01303939. IPD Sharing: NO. Countries: 1. Publications: 1.
A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes
ClinicalTrials.gov study NCT02017171. IPD Sharing: Not stated. Countries: 3. Publications: 7.
A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:
ClinicalTrials.gov study NCT02065479. IPD Sharing: NO. Countries: 1. Publications: 1.
Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients
ClinicalTrials.gov study NCT01990495. IPD Sharing: NO. Countries: 1. Publications: 2.
Single-arm Study With Bimiralisib in Patients With HNSCC Harboring NOTCH1 Loss of Function Mutations
ClinicalTrials.gov study NCT03740100. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study of the Effect of Liraglutide on Weight Loss and Gastric Functions in Obesity
ClinicalTrials.gov study NCT02647944. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
ClinicalTrials.gov study NCT01351753. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-F
ClinicalTrials.gov study NCT01604824. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
ClinicalTrials.gov study NCT01785719. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Repeated loss of function at HD mating-type genes and of recombination suppression without mating-type locus linkage in anther-smut fungi
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Data from: Gα and regulator of G-protein signaling (RGS) protein pairs maintain functional compatibility and conserved interaction interfaces throughout evolution despite frequent loss of RGS proteins in plants
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Trait-based mechanistic approach highlights global patterns and losses of herbivore biomass functional diversity
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Data and code from: Loss of resource-conservative species affects plant phylogenetic and functional structure under long-term snow addition
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Experimental facilitation of heat loss affects work rate and innate immune function in a breeding passerine bird
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Afforestation and abandonment of semi-natural grasslands lead to biodiversity loss and a decline in ecosystem services and functions
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Data from: Incomplete loss of a conserved trait: function, latitudinal cline, and genetic constraints
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Data from: Forest loss and treeless matrices cause the functional impoverishment of sapling communities in old-growth forest patches across tropical regions
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.