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13,349 results for “mice”
Data_Supplemental_Fig2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental figure 2 as PNG-format (PNTD-D-21-00134R2_SFig2.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf).</p> <p>Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_2_1-26_M_1.txt) and two files in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_M_2-3.pdf).</p>
Data_Supplemental_Fig3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental figure 3 as PNG-format (PNTD-D-21-00134R2_SFig3.png). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as two files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_1-2.csv), all further experiment related information provided as one meta-data-file in txt format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_1.txt) and seven meta data files in pdf format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_2-4.pdf and 31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_M_1-3.pdf).</p>
Data_Supplemental_Fig1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p> </p> <p>The Dataset contains the original supplemental figure 1 as PNG-format (PNTD-D-21-00134R2_SFig1.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_2.pdf).</p>
Data_Figure4_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig4, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 4 as PNG-format (PNTD-D-21-00134R2_Fig4.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_Fig4_M_1.txt).</p>
Data_Figure3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 3 as PNG-format (PNTD-D-21-00134R2_Fig3.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and raw blots as the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf). Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_2_13-14_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_M_2.pdf).</p>
Data_Figure2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 2 as PNG-format (PNTD-D-21-00134R2_Fig2.png). Corresponding raw data and subsequent data analysis obtained from Multiplex Luminex Cytokine measurement analysis provided as one files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_1.csv). All further experiment related information (meta-data) provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_M_2.pdf).</p>
Data_Figure1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p> </p> <p>The Dataset contains the original figure 1 as PNG-format (PNTD-D-21-00134R2_Fig1.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf), original supp. Figure S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf).</p> <p>Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_2_1-26_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_2.pdf).</p>
Data from: Predation of wood mice (Apodemus sylvaticus) on hibernating bats
<p>In order to protect hibernating bats effectively, more knowledge about mortality factors is needed. This study proved the wood mouse (<em>Apodemus sylvaticus</em>) actively predates on bats. Fresh remains made by the wood mouse can be identified due to a typical pattern of lesions.</p> <p>This study was conducted in the province of Zuid-Holland, between the cities of Den Haag (The Hague), Leiden and the town of Wassenaar (between 52-070 and 52-090N, 4-180 and 4-210E). During a preliminary investigation with a trail camera, we were able to prove that wood mice actively searched for prey. Thereafter, remains of partially eaten bats have been collected and inspected in the laboratory. Bats which had not died of predation were excluded from the analysis. The remains that we found showed the typical pattern of lesions attributable to predation by wood mice. The skin of the victims is scraped clean. In the process of eating all the soft tissue, the skin is turned inside out, including the skin around the skull and hind legs. We found a total of 214 remains of predated bats during the 12 years. The resulting data are presented in this dataset.</p> <p> </p> <p>Files</p> <p><strong>Distance to entrance</strong></p> <p>Status: status of observation, this is a filter for fresh remains.</p> <p>Date: date of the observation of the remains. Note: observations were made each 2 weeks, not necessarily the date of death.</p> <p>Species: fresh remains of what bat species</p> <p>Location: name of hibernacula, location of observation</p> <p>N of animals: number of fresh remains</p> <p>Distance: distance to the exit (in meters)</p> <p> </p> <p><strong>Oak and predation</strong></p> <p>Winter: the period between September and April is defined as the winter of the year starting in January</p> <p>Predation: N of fresh remains found in one winter</p> <p>Cumulative N of bats: The cumulative population, based on the maximum population size of each site.</p> <p>Mast production of the common oak (kg): kg of acorns. We used annual data on the seed production of common oak collected by the ‘Vereniging Wildbeheer Veluwe’ in the province of Gelderland as a measure for the availability of acorns in our study area.</p> <p> </p> <p><strong>Predation and winter population</strong></p> <p>Winter: the period between September and April is defined as the winter of the year starting in January</p> <p>Predation: the Number of predated bats</p> <p>Max N: the maximum population size</p> <p>Location: the hibernacula</p>
Diallel analysis reveals Mx1-dependent and Mx1-independent effects on response to influenza A virus in mice
<p>Data and analysis files for diallel analysis of weight loss in 8-12 week old male and female mice (n=1,043), mock treated or infected with influenza A virus (H1N1, PR8) across 4 days post-infection, as well as founder haplotype effect analysis at Mx1 for pre-CC and CC-RIX.</p>
Age-related proteostatic imbalance exacerbates heart failure with preserved ejection fraction pathogenesis in old mice
<p>Heart failure with preserved ejection fraction (HFpEF) is a leading cause of hospitalization and death in the elderly. While aging strongly increases the incidence of HFpEF, the specific influences of aging on HFpEF at molecular and pathophysiological levels remain unclear. Here, we show that aged mice, when subjected to chronic metabolic and hypertensive stress (2-hit stress), develop an aggravated cardiometabolic HFpEF phenotype compared to younger counterparts. Aged HFpEF mice also display unique pathological characteristics reminiscent of those found in HFpEF patients. We demonstrate that age-related dysfunction in protein quality control (PQC) exacerbates proteostatic stress in HFpEF. Specifically, we demonstrate that increased protein synthesis induced by 2-hit stress combines with age-related impairment in protein degradation in aged HFpEF hearts, culminating in the accumulation of protein aggregates. These findings underscore the importance of incorporating aging into preclinical HFpEF models and support the therapeutic potentials of targeting PQC mechanisms to ameliorate disease outcomes.</p> <p>The deposited data are lc-ms data acquired on the Thermo QEx-Plus system. For any questions, please contact mike kinter mike-kinter at omrf.org</p> <p>This upload contains the bulk of the LC-MS data. But, due to file sizes, and addition group of files can be found at doi 10.5281/zenodo.11094720</p>
Correlative microscopy of mice cerebellar Purkinje cells from 20x confocal tissue imaging to super-resolution 93x 3D STED of dendritic spines
<p>This Dataset concerns the paper entitled "<em>From tissues to segmentation: a modular framework for multi-scale neuron isolation</em>" by Cauzzo et al. <strong>Nature Comm (2024).</strong></p> <p>S.Cauzzo<sup>$</sup>, E. Bruno, D. Boulet, P. Nazac, M. Basile, A. L. Callara, F. Tozzi, A. Ahluwalia, C. Magliaro, L. Danglot<sup>$</sup><sup>*</sup>, N. Vanello<sup>$</sup><sup>*</sup> *shared senior authorship: Lydia.danglot@inserm.fr ; nicola.vanello@unipi.it</p> <p><sup>$</sup> corresponding authors : cauzzo.simone@gmail.com ; Lydia.danglot@inserm.fr ; nicola.vanello@unipi.it</p> <p> </p>
Data set of pup retrieval test in control and V1b vasopressin receptor knockout mice
<div> <div> <div> <p>This repository contains the images and code used in the paper "Computer vision analysis of mother-infant interaction identified efficient pup retrieval in V1b receptor knockout mice".</p> <p>For effective nursing, close contact between lactating mothers and their infants is necessary. However, evaluation of maternal motivation to retrieve pups is challenging, because multiple infants were randomly accessed multiple times in changing background. We applied computer vision and deep learning analysis in this process to precisely calculate maternal behavior. Object detection in an open filed test identified less entry into the center area and less moving distance in virgin female mice lacking V1b vasopressin receptor (V1bKO) than wild-type (WT) mice. Although this character was replicated in a V1bKO mother, a pup retrieval test showed that total distances among a V1bKO mother and infants come closer in a shorter time than with a WT mother. In the medial preoptic area, V1b receptor message was partly detected in galanin- and c-fos-positive neurons after the mother was stimulated by infants. Our deep learning analysis effectively evaluated mother-infant relationship in V1bKO mice.</p> </div> </div> </div>
Flow cytometry of mesenteric lymph nodes, small and large intestinal lamina propria, and spinal cord cells from fibre-rich and fiber-free diet-fed gnotobiotic mice at baseline and after experimental autoimmune encephalomyelitis (EAE) induction
<p>We perform profiling of different immune cell populations in the small (SILP) and large intestine lamina propria (CLP), mesenteric lymph nodes (MLN) and spinal cords (SC). We are specifically interested to evaluate the impact of dietary fiber deprivation followed by mucus erosion on the immune cell profiles of T helper cells (Th cells, T cell population) of gnotobiotic mice fed a fiber-rich (FR) or fiber-free (FF) diet. This dataset aims to assess the impact of microbiome and diet on disease course in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE) via T cell populations. Mice are either germ-free or colonized by intragastric gavage with a defined variation of a 14-member synthetic human gut microbiome (doi: 10.1016/j.cell.2016.10.043 and 10.1016/j.xpro.2021.100607): SM01 (Akkermansia muciniphila monocolonisation), SM03 (Bacteroides caccae, Bacteroides thetaiotaomicron, Barnesiella intestinihominis), SM04 (B. caccae, B. thetaiotaomicron, B. intestinihominis, A. muciniphila), SM12 (full community except mucin-specialists B. intestinihominis and A. muciniphila), SM13 (full community except mucin specialist A. muciniphila), or SM14 (full community: Roseburia intestinalis, Faecalibacterium prausnitzii, Marvinbryantia formatexigens, Collinsella aerofaciens, Desulfovibrio piger, B. caccae, B. thetaiotaomicron, Bacteroides ovatus, Bacteroides uniformis, B. intestinihominis, Eubacterium rectale, Clostridium symbiosum, Escherichia coli, and A. muciniphila). At age 5 to 8 weeks, mice were colonized with SM combinations while fed an FR diet. Mice were either maintained on an FR diet or switched to an FF diet at 5 days after initial colonization, until the end of experiment. Baseline samples were collected 20 days following the diet switch. Otherwise, EAE induction was performed 15 days after the diet switch and samples were collected 30 days after the induction.</p>
Data set for "State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice"
<p>Data set for: Pala A, Petersen CCH (2018) State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice. eLife 7: e35869. DOI: https://doi.org/10.7554/eLife.35869.</p> <p>There are 12 files in this data upload:</p> <p>1. '2018_Pala_eLife.pdf' - this is a pdf version of the online publication: Pala & Petersen (2018).</p> <p>2. 'data.mat' - this is a Matlab data structure, which contains all the data for the publication.</p> <p>3. 'DataViewer.m' - this is a Matlab code for viewing the data.</p> <p>4. 'DataViewer.fig' - this is a Matlab figure file, which is the GUI layout for 'DataViewer.m'.</p> <p>5. 'PalaPetersen_Plot.m' - this is a Matlab code, which plots the figures for Pala & Petersen (2018).</p> <p>6. 'PalaPetersen_Analysis.m' - this is a Matlab code, which analyses the data for the figures of Pala & Petersen (2018).</p> <p>7. 'blankAPs.m' - this is a Matlab code, which blanks action potentials from the membrane potential trace.</p> <p>8. 'lowpassfilt.m' - this is a Matlab code, which low pass filters the LFP.</p> <p>9. 'medianFiltAPs.m' - this is a Matlab code, which median filters the membrane potential trace to remove action potentials.</p> <p>10. 'remTrialswithAPs.m' - this is a Matlab code, which removes trials with action potentials.</p> <p>11. 'retrieveSegDur.m' - this is a Matlab code, which retrieves chunks of the recording of a given length.</p> <p>12. 'suptitleAP.m' - this is a Matlab code, which puts titles above subplots.</p>
Dataset for "Synchrotron-based phase contrast imaging of cardiovascular tissue in mice—grating interferometry or phase propagation?"
<p>This dataset contains images that were used in the analysis of the manuscript "Synchrotron-based phase contrast imaging of cardiovascular tissue in mice—grating interferometry or phase propagation?", that was published in Biomedical Physics and Engineering Express in 2018. Images are uploaded in .tif format. Three different synchrotron-based imaging techniques were compared on the same cardiovascular samples: grating interferometry (GI) and absorption-based phase propagation with and without phase retrieval according to Paganins method. An excel file is provided in which the nomenclature of the files is explained.</p>
scRNA-seq of KPC mice
<p>This is processed and zipped data from GSE129455. Users can use the "readRDS(file = filename)" function in the R programming language to access it.</p>
Widefield and Confocal brain images derived from experimental Middle Cerebral Artery occlusion (MCAo) in mice.
<p>This deposit contains a series of widefield and confocal brain images derived from research on cerebral ischemia carried out by the Laboratory of Neurovascular Interactions (https://elalilab.com/) at the Université Laval, Québec (Canada) directed by Dr. Ayman ElAli (<a href="mailto:ayman.el-ali@crchudequebec.ulaval.ca">ayman.el-ali@crchudequebec.ulaval.ca</a>). The experiments, data processing, and organization were performed by Daniel Manrique-Castano, former postdoctoral fellow and current research data curation officer at the Digital Research Alliance of Canada (<a href="https://daniel-manrique.github.io/">https://daniel-manrique.github.io/manrique; </a>dmanriquecastano@gmail.com).</p> <p>Given the complexity of the whole image bundle, images from the same experiment were compressed into zip files. Complementary data is available at the <strong>Open Science Framework (OSF) repository</strong> (<span><a href="https://osf.io/74mqn/" target="_blank" rel="noopener">10.17605/OSF.IO/74MQN</a>), and reproducible workflows for image processing and analysis are available on <strong>GitHub</strong> (<a href="https://doi.org/10.5281/zenodo.13948420" target="_blank" rel="noopener">10.5281/zenodo.13948420</a>)</span></p> <p> </p> <p><strong>Naming conventions for datasets</strong> (taking as an example Widefield_5x_Ipsilateral_KO_CD31-ColIV-Iba1.zip)</p> <p>Widefield: Imaging type performed (available strings = Confocal, Widefield). </p> <p>5x: Objective magnification (Available strings = 5x, 10x, 20x, 40x). </p> <p>Ipsilateral: Iaged region (Available strings = ROIs [Regions of interest], Whole [whole brain], Ipsilateral [ischemic hemisphere]). </p> <p>KO: imaging performed in PDGFRB_KLF4-KO mice (if absent, imaging performed in PDGFRB_TdTomato mice) </p> <p>CD31-ColIV-Iba1: Imaged markers (available strings = multiple, depending on the experiment). </p> <p> </p> <p><strong>Important: </strong>Each .zip file contains a README file specific to each dataset, describing the experimental conditions, naming conventions of individual images and links to additional files used for image processing.</p> <p> </p> <p> </p>
Mice infected with High shedder S. mansoni parasites from cross A - cage 1 - Liver histopathology data.
<p>The present dataset contains all the histopathology images used to quantify fibrotic areas, parasite egg counts and to quantify granuloma areas in liver of mice infected with <em>S. mansoni</em> High shedder line. These data are presented in the manuscript entitled "No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host" (dataset # 2/11).<br> Each folder corresponds to one mouse sample and contain, along with a readme file, all the files used to quantify fibrotic area and egg counts (_TRICH.czi), to quantify granuloma area (_HE.czi), and the annotation file (.annotations) containing all the annotated granuloma areas.</p>
Mice infected with High shedder S. mansoni parasites from cross A - cage 2 - Liver histopathology data.
<p>The present dataset contains all the histopathology images used to quantify fibrotic areas, parasite egg counts and to quantify granuloma areas in liver of mice infected with S. mansoni High shedder line. These data are presented in the manuscript entitled "No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host" (dataset # 3/11).<br> Each folder corresponds to one mouse sample and contain, along with a readme file, all the files used to quantify fibrotic area and egg counts (_TRICH.czi), to quantify granuloma area (_HE.czi), and the annotation file (.annotations) containing all the annotated granuloma areas.</p> <p> </p>
Mice infected with High shedder S. mansoni parasites from cross B - cage 1 - Liver histopathology data.
<p>The present dataset contains all the histopathology images used to quantify fibrotic areas, parasite egg counts and to quantify granuloma areas in liver of mice infected with <em>S. mansoni</em> High shedder line. These data are presented in the manuscript entitled "No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host" (dataset # 6/11).<br> Each folder corresponds to one mouse sample and contain, along with a readme file, all the files used to quantify fibrotic area and egg counts (_TRICH.czi), to quantify granuloma area (_HE.czi), and the annotation file (.annotations) containing all the annotated granuloma areas.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.