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165 results for “nucleoside”
Supplementary Information for "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications"
<p>This is the external Supplementary Information for our publication "Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications".</p> <p>The .zip files contains the raw data and metadata for all items (supplementary and main text) as well as the calculation results. This includes UV, HPLC, NMR, DFT and MD results. This revised version presents extended DFT results (now including dispersion contributions) as well as additional NMR data (now including analytical data for isolated 1f, among other data).</p> <p>To some extent, this work builds on and borrows from our previous publications on spectral unmixing (https://doi.org/10.3390/mps2030060, https://doi.org/10.1002/cbic.202000204), continuous reaction monitoring (https://doi.org/10.1021/acs.analchem.1c05356), and thermodynamic reaction control (https://doi.org/10.1002/adsc.201901230, https://doi.org/10.5281/zenodo.3568858, https://doi.org/10.1002/cphc.202000901, https://doi.org/10.1021/acscatal.1c02589).</p>
Screening for nucleoside inhibitors of the SARS-CoV-2 RdRP
<p>This report describes the most relevant results of screening compounds with a nucleoside analogue structure from the Janssen Pharmaceutica compound collection for potential activity against SARS-CoV-2 in a cell-based assay and nucleoside triphosphates in a radioactive filtering binding RdRP assay.</p>
Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex–Duplex Hybrid Formation
<p>„Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex–Duplex Hybrid Formation”.</p> <p>In article, a method to discriminate between two target RNA sequences that differ by one nucleotide only is presented. The method relies on the formation of alternative structures, i.e., quadruplex–duplex hybrid (QDH) and duplex with dangling ends (Dss), after hybridization of RNA G-rich oligonucleotides with target sequences containing 5′–GGGCUGG–3′ (U<sup>T</sup>) or 5′–GGGCGGG–3′ (G<sup>T</sup>) fragments. Using biophysical methods, the effect of covalently attached G4 ligand on the ability of G-rich oligonucleotides to assemble a G-quadruplex motif was studied. The sequence-guided o-BMVC G4-ligand acted as a quadruplex stabilizer but not duplex. The use of such conjugates (o-BMVC-RNA) creates the possibility of inducing and stabilizing the bimolecular quadruplexes on the G-rich mRNA template in a sequence-specific manner. The formation of QDH or Dss structures is dependent on a single nucleotide change in the target sequence, and the possibility to selectively stabilize the G-quadruplex domain by attaching the G4 ligand may become an attractive alternative therapy for patients with an EGFR-L858R mutation.</p> <p><a href="https://www.mdpi.com/2218-273X/11/8/1236">https://www.mdpi.com/2218-273X/11/8/1236</a>, <a href="https://doi.org/10.3390/biom11081236">https://doi.org/10.3390/biom11081236</a></p> <p>Files are available in original formats: .xlsx, .opi, bruker, MultiGauge raw-image file (.img), JPG file (.jpg), text document (.txt)</p>
An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
ClinicalTrials.gov study NCT03845712. IPD Sharing: YES. Countries: 3. Publications: 1.
A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3
ClinicalTrials.gov study NCT00000625. IPD Sharing: Not stated. Countries: 3. Publications: 11.
Nucleosides And Darunavir/Dolutegravir In Africa
ClinicalTrials.gov study NCT03988452. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination With Nucleoside Analogs: A Rollover Study for ACTG 320
ClinicalTrials.gov study NCT00000885. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Switching the Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) or Protease Inhibitor (PI) to Maraviroc in HIV Subjects
ClinicalTrials.gov study NCT00966329. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevention of HIV1 Mother to Child Transmission Without Nucleoside Analogue Reverse Transcriptase Inhibitors in the Pre-partum Phase. ANRS 135 Primeva
ClinicalTrials.gov study NCT00424814. IPD Sharing: Not stated. Countries: 1. Publications: 2.
"OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects
ClinicalTrials.gov study NCT00114933. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Patients Treated by a First Line Treatment Containing Dolutegravir and Associated Nucleoside / Nucleotide R
ClinicalTrials.gov study NCT04133012. IPD Sharing: NO. Countries: 1. Publications: 0.
HBsAg Decline After Pegylated-interferon-α in e Antigen Positive Chronic Hepatitis B With Nucleoside Maintenance
ClinicalTrials.gov study NCT01769833. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
ClinicalTrials.gov study NCT04500847. IPD Sharing: NO. Countries: 1. Publications: 1.
A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
ClinicalTrials.gov study NCT00000781. IPD Sharing: Not stated. Countries: 2. Publications: 2.
A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4
ClinicalTrials.gov study NCT00000859. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Immunologic Effects of Supplemental Monosaccharide and Nucleoside Derivatives in Patients With Inherited Disorders of Glycosylation
ClinicalTrials.gov study NCT02511041. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of a Nucleoside Sparing Regimen in HIV-1 Infected Patients With Detectable Viremia
ClinicalTrials.gov study NCT02542852. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy
ClinicalTrials.gov study NCT00000831. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Determinants of Virological Response After Discontinuation of Nucleoside Analogue Therapy in Hepatitis B Patients
ClinicalTrials.gov study NCT02581033. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Nucleoside (Acid) Analogues Treatment in Patients With Normal ALT and Positive HBVDNA.
ClinicalTrials.gov study NCT04231565. IPD Sharing: YES. Countries: 1. Publications: 4.
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International Brain Laboratory public data
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OpenNeuro
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