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118 results for “oxidative damage”
Post-exercise Therapeutic Modalities on Functional Performance, Muscle Damage and Oxidative Stress of CrossFit® Athletes
ClinicalTrials.gov study NCT06628609. IPD Sharing: YES. Countries: 1. Publications: 0.
Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE (OSAS)
ClinicalTrials.gov study NCT01635699. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lemon Verbena Extract Oxidative Stress and Muscle Damage
ClinicalTrials.gov study NCT04742244. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle
ClinicalTrials.gov study NCT01644279. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Inter-generational costs of oxidative stress: reduced fitness in daughters of mothers that experienced high levels of oxidative damage during reproduction
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Data from: Carotenoids, birdsong and oxidative status: administration of dietary lutein is associated with an increase in song rate and circulating antioxidants (albumin and cholesterol) and a decrease in oxidative damage
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Data from: Oxidative damage and antioxidant defence are assay and tissue dependent both in captive and in wild-caught bank voles (Myodes glareolus) before and after reproduction
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Data from: Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation
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Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment
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Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality
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Data from: Carry-over effects of early thermal conditions on somatic and germline oxidative damages are mediated by compensatory growth in sticklebacks
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Data from: Eating increases oxidative damage in a reptile
While eating has substantial benefits in terms of both nutrient and energy acquisition, there are physiological costs associated with digesting and metabolizing a meal. Frequently, these costs have been documented in the context of energy expenditure while other physiological costs have been relatively unexplored. Here, we tested whether the seemingly innocuous act of eating affects either systemic pro-oxidant (reactive oxygen metabolites: ROM) levels or antioxidant capacity of corn snakes (Pantherophis guttatus) by collecting plasma during absorptive (peak increase in metabolic rate due to digestion of a meal) and non-absorptive (baseline) states. When individuals were digesting a meal, there was a minimal increase in antioxidant capacity relative to baseline (4%), but a substantial increase in ROMs (nearly 155%), even when controlling for circulating nutrient levels. We report an oxidative cost of eating that is much greater than that due to long distance flight or mounting an immune response in other taxa. This result demonstrates the importance of investigating non-energetic costs associated with meal processing, and it begs future work to identify the mechanism(s) driving this increase in ROM levels. Because energetic costs associated with eating are taxonomically widespread, identifying the taxonomic breadth of eating-induced ROM increases may provide insights into the interplay between oxidative damage and life history theory.
Data from: Large-brained birds suffer less oxidative damage
Large brains (relative to body size) might confer fitness benefits to animals. Although the putative costs of well-developed brains can constrain the majority of species to modest brain sizes, these costs are still poorly understood. Given that the neural tissue is energetically expensive and demands antioxidants, one potential cost of developing and maintaining large brains is increased oxidative stress ('oxidation exposure' hypothesis). Alternatively, because large-brained species exhibit slow-paced life histories, they are expected to invest more into self-maintenance such as an efficacious antioxidative defence machinery ('oxidation avoidance' hypothesis). We predict decreased antioxidant levels and/or increased oxidative damage in large-brained species in case of oxidation exposure, and the contrary in case of oxidation avoidance. We address these contrasting hypotheses for the first time by means of a phylogenetic comparative approach based on an unprecedented dataset of 4 redox state markers from 85 European bird species. Large-brained birds suffered less oxidative damage to lipids (measured as malondialdehyde levels) and exhibited higher total non-enzymatic antioxidant capacity than small-brained birds, while uric acid and glutathione levels were independent of brain size. These results were not altered by potentially confounding variables and did not depend on how relative brain size was quantified. Our findings partially support the 'oxidation avoidance' hypothesis and provide a physiological explanation for the linkage of large brains with slow-paced life histories: reduced oxidative stress of large-brained birds can secure brain functionality and healthy lifespan, which are integral to their lifetime fitness and slow-paced life history.
How Do Xanthophylls Protect Lipid Membranes from Oxidative Damage?
<p><span>equatorial optical cross-sections of liposomes recorded with the FLIM technique<br></span></p>
Food restriction delays breeding and affects insulin-like growth factor-1, oxidative damage, and haematocrit value before egg-laying in female canaries
<p>Environmental challenges, such as fluctuations in food availability, could influence reproductive investment. If resource availability is poor, individuals need to decide in which life-history process they invest more energy and vital compounds, which determine the cost of reproduction. In resource allocation, the physiological pathways have important roles. The aim of our study was to examine whether food availability influenced physiological traits (insulin-like growth factor-1 (IGF-1) concentration, antioxidant capacity (OXY), level of oxidative damage (ROM) and haematocrit value) prior to egg-laying in female canaries (<i>Serinus canaria</i>). We also tested whether these physiological traits were associated with traits reflecting the reproductive investment in egg macro- (egg mass and yolk mass) and micronutrient content (eggshell biliverdin- and protoporphyrin-based colouration). To test these questions we conducted a food restriction experiment with control and food-restricted (72% of control food) groups. Our study showed that food-restricted canary females delayed egg-laying and the physiological traits differed between the groups. At the pre-laying period, after 9-11 days of treatment, a reduction in plasma IGF-1 concentration, ROM level, and haematocrit value was detected in the control group, whereas in the food-restricted group plasma IGF-1 concentration increased, while ROM level and haematocrit value did not change. Plasma level of OXY was not influenced by treatment or breeding period. Plasma concentration of IGF-1, haematocrit value and oxidative status before egg laying did not affect the egg characteristics. Our study highlights the importance of breeding stage when studying and interpreting the effects of food restriction on physiological traits of breeding birds. Moreover, our data suggest that nutritional limitation had an effect on the timing of egg-laying that could be mediated by changes in physiological variables.</p>
Figure 2 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 2. Testicular tissue, control group, negative Tnf-α expression (A). T 3 h / D 3 h group: very severe Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (B). T 3 h / D 24 h group: severe Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (C). T 3 h / D 3 h + silymarin group: medium level Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (D). T 3 h / D 24 h + silymarin group: mild Tnf-α expression in the perivascular and intertubular intervals (arrowheads) (E). IHC-P, bar: 50 µm.
Figure 1 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 1. Testicular tissue, control group, normal histological view (A). T 3 h / D 3 h group: necrosis in spermatocytes (arrowheads); severe congestion in intertubular intervals (thick arrows); hemorrhage, thinning in the tubulus wall (B). T 3 h / D 24 h: necrosis in spermatocytes (arrowheads); severe edema in the intertubular space (stars); thinning of the tubulus wall (C). T 3 h / D 3 h + silymarin group: moderate edema in the intertubular intervals (star); congestion (thick arrow) (D). T 3 h / D 24 h + silymarin group: mild edema at intertubular intervals (star) (E); H and E, bar: 50 µm.
Figure 3 in Investigation of the effect of silymarin on oxidative DNA damage and inflammatory markers in ischemia/reperfusion injury following experimental testicular torsion/detorsion in rats
Figure 3. Testicular tissue, control group, negative 8-OHdG expression (A). T 3 h / D 3 h group: severe cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (B). T 3 h / D 24 h group: severe cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (C). T 3 h / D 3 h + silymarin group: moderate cytoplasmic 8-OHdG expression in spermatocytes (arrowheads) (D). T 3 h / D 24 h + silymarin group: mild cytoplasmic 8-OHdG expression in spermatocytes (E), IHC-P, bar: 50 µm.
Limb RIPC in Patients Undergoing Lung Lobectomy. Study of Oxidative Lung Damage
ClinicalTrials.gov study NCT02734654. IPD Sharing: NO. Countries: 0. Publications: 5.
Oxidative Damage and Antioxidant Mechanisms in COPD
ClinicalTrials.gov study NCT02406053. IPD Sharing: Not stated. Countries: 0. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.