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2,019
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Dataset results
2,019 results for “pediatric patients”
Study of Efficacy and Safety of CTL019 in Pediatric ALL Patients
ClinicalTrials.gov study NCT02435849. IPD Sharing: YES. Countries: 11. Publications: 7.
A Study to Assess Safety and Efficacy of Avalglucosidase Alfa Administered Every Other Week in Pediatric Patients With Infantile-onset Pompe Disease Previously Treated With Alglucosidase Alfa
ClinicalTrials.gov study NCT03019406. IPD Sharing: YES. Countries: 5. Publications: 2.
Safety, Efficacy and PK of BIVV001 in Pediatric Patients With Hemophilia A
ClinicalTrials.gov study NCT04759131. IPD Sharing: YES. Countries: 15. Publications: 3.
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum
ClinicalTrials.gov study NCT04589650. IPD Sharing: YES. Countries: 12. Publications: 2.
ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab
ClinicalTrials.gov study NCT02296424. IPD Sharing: UNDECIDED. Countries: 16. Publications: 1.
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment
ClinicalTrials.gov study NCT02055118. IPD Sharing: YES. Countries: 7. Publications: 3.
Study to Assess the Long-term Safety, Tolerability, Efficacy of Secukinumab in Pediatric Patients of Age 6 to <18 Years, With Moderate to Severe Plaque Psoriasis
ClinicalTrials.gov study NCT03668613. IPD Sharing: YES. Countries: 9. Publications: 4.
Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of rhHNS Administration Via an IDDD in Pediatric Patients With Early Stage MPS IIIA Disease
ClinicalTrials.gov study NCT02060526. IPD Sharing: YES. Countries: 8. Publications: 1.
Efficacy, Safety and Pharmacokinetics of Teriflunomide in Pediatric Patients With Relapsing Forms of Multiple Sclerosis
ClinicalTrials.gov study NCT02201108. IPD Sharing: YES. Countries: 22. Publications: 3.
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia
ClinicalTrials.gov study NCT02961218. IPD Sharing: YES. Countries: 7. Publications: 1.
Host biomarkers and combinatorial scores for the detection of serious and invasive bacterial infection in pediatric patients with fever without source
<h3><span>Background </span></h3> <p><span>Improved tools are required to detect bacterial infection in children with fever without source (FWS), especially when younger than 3 years old. The aim of the present study was to investigate the diagnostic accuracy of a host signature combining for the first time two viral-induced biomarkers, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon </span><span>γ</span><span>-induced protein-10 (IP-10), with a bacterial-induced one, C-reactive protein (CRP), to reliably predict bacterial infection in children with fever without source (FWS) and to compare its performance to routine individual biomarkers (CRP, procalcitonin (PCT), white blood cell and absolute neutrophil counts, TRAIL, and IP-10) and to the Labscore.</span></p> <h3><span>Methods</span></h3> <p><span>This was a prospective diagnostic accuracy study conducted in a single tertiary center in children aged less than 3 years old presenting with FWS. Reference standard etiology (bacterial or viral) was assigned by a panel of three independent experts. Diagnostic accuracy (AUC, sensitivity, specificity) of host individual biomarkers and combinatorial scores was evaluated in comparison to reference standard outcomes (expert panel adjudication and microbiological diagnosis). </span></p> <h3><span>Results </span></h3> <p><span>241 patients were included. 68 of them (28%) were diagnosed with a bacterial infection and 5 (2%) with invasive bacterial infection (IBI). Labscore, ImmunoXpert, and CRP attained the highest AUC values for the detection of bacterial infection, respectively 0.854 (0.804–0.905), 0.827 (0.764–0.890), and 0.807 (0.744–0.869). Labscore and ImmunoXpert outperformed the other single biomarkers with higher sensitivity and/or specificity and showed comparable performance to one another although slightly reduced sensitivity in children < 90 days of age.</span></p> <h3><span>Conclusion </span></h3> <p><span>Labscore and ImmunoXpert demonstrate high diagnostic accuracy for safely discriminating bacterial infection in children with FWS aged under and over 90 days, </span><span>supporting their adoption in the assessment of febrile patients. </span></p>
Longitudinal trends of EHR concepts in pediatric patients
<p>The longitudinal nature of the data motivated temporal trend identification in the pediatric EHR datatypes. Over the past three decades (1980-2018), we identified and quantified the temporal trend of 16,460 EHR concepts across measurement, visit, diagnosis, drug, and procedure datatypes. </p>
An Assessment of Medication Errors among Pediatric Patients in Three Hospitals in Freetown Sierra Leone: Findings and Implications for a Low-Income Country
<p> </p><p><strong>Background</strong></p><p>Pediatric patients are prone to medicine-related problems like medication errors (MEs), which can potentially cause harm. Yet, this has not been studied in this population in Sierra Leone. Therefore, this study investigated the prevalence and nature of MEs, including potential drug-drug interactions (pDDIs) in pediatric patients in three hospitals in Freetown, Sierra Leone.</p><p><strong>Methods: </strong>The study was conducted in three Hospitals among pediatric patients in Freetown and consisted of two phases. Phase one was a cross-sectional retrospective review of prescriptions for completeness and accuracy against standard prescription writing guidelines. Phase two was a point prevalence inpatient chart review of MEs that were categorized into prescription, administration, and dispensing errors and pDDIs. Data was analyzed using frequency, percentages, median, and interquartile range. Kruskal-Wallis H and Mann-Whitney U tests were used to compare the prescription accuracy between the hospitals, with p<0.05 considered statistically significant.</p><p><strong>Results: </strong>In phase one<strong>, </strong>while no prescription attained the global accuracy score (GAS) gold standard of 100%, 106 (29.0%) achieved the 80-100% mark. The patient 63 (17.2%), treatment 228 (62.3%), and prescriber 33 (9.0%) identifiers achieved an overall GAS range of 80-100%. Although the total GAS was not statistically significant (p=0.065), the date (p=0.041), patient (p=<0.001), treatment (p=0.022), and prescriber (p=<0.001) identifiers were statistically significant across the different hospitals. For phase two, the prevalence of MEs was 74 (56.1%), while that for pDDIs was 54 (40.9%). There was a statistically positive correlation between the occurrence of pDDI and the number of medicines prescribed (r=0.211, P=0.015).</p><p><strong>Conclusion: </strong>Low GAS depicts poor compliance with prescription writing guidelines and high prescribing errors. Medication errors were observed at each phase of the medication use cycle, while clinically significant pDDIs were also reported. Thus, there is a need for training on prescription writing guidelines and medication errors.</p><p> </p><p><strong>Keywords:</strong> Pediatrics, Prescription, Medication errors, Drug-drug interactions, Sierra Leone</p>
Feasibility of Monitoring Health Data in Pediatric Patients Undergoing Chemotherapy
ClinicalTrials.gov study NCT04134429. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Efficacy Study of Romiplostim to Treat Immune Thrombocytopenia (ITP) in Pediatric Patients
ClinicalTrials.gov study NCT01444417. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Long-Term Study of TAU-284 in Pediatric Patients With Perennial Allergic Rhinitis
ClinicalTrials.gov study NCT01900054. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
ClinicalTrials.gov study NCT03541980. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery
ClinicalTrials.gov study NCT02747875. IPD Sharing: NO. Countries: 1. Publications: 24.
Randomized Controlled Trial Comparing Adult to Pediatric Colonoscope in Obese Patients.
ClinicalTrials.gov study NCT06776913. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
ClinicalTrials.gov study NCT02808650. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.