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293
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Dataset results
293 results for “protein kinase”
Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene
ClinicalTrials.gov study NCT00588445. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome
ClinicalTrials.gov study NCT00690755. IPD Sharing: NO. Countries: 1. Publications: 5.
p38 Mitogen-Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
ClinicalTrials.gov study NCT00676572. IPD Sharing: NO. Countries: 1. Publications: 1.
Protein Kinase C (PKC) Inhibitor-Diabetic Retinopathy Phase 3 Study
ClinicalTrials.gov study NCT00604383. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II S
ClinicalTrials.gov study NCT01229150. IPD Sharing: NO. Countries: 1. Publications: 4.
DNA-PKcs RNASeq data: DNA-PKcs wilde-type or kinase-dead protein regulate basal and etoposide-induced gene expression changes
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Data from: Two cGMP-dependent protein kinases have opposing effects on molt-inhibiting hormone regulation of Y-organ ecdysteroidogenesis
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Confocal microscopy of fixed larval Drosophila CNS stained with antibodies to detect atypical Protein Kinase C
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MD simulations data for: Role of the αC-β4 loop in protein kinase structure and dynamics
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Data from: Protein kinase FaSnRK2.6 phosphorylates transcription factor FabHLH3 to regulate anthocyanin homeostasis during strawberry fruit ripening
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Dataset related to publication: "Bromo-substituted indirubins for inhibition of protein kinase-mediated signalling involved in inflammatory mediator release in human monocytes"
<p>Dataset related to publication: Bachmann et al. "Bromo-substituted indirubins for inhibition of protein kinase-mediated signalling involved in inflammatory mediator release in human monocytes". Bioorganic Chemistry (2024) https://doi.org/10.1016/j.bioorg.2024.107470 </p> <ul> <li>Full Desmond MD simulation trajectories of the 10 replica simulations of compounds <strong>1</strong> and <strong>2</strong> bound to GSK-3beta (.zip files contain the -out.cms file and the trajectory)</li> <li>Maestro Glide XP docking output pose viewer files of compounds <strong>1 </strong>and <strong>2</strong> for CDKs (PDB IDs in the filenames)(.maegz -files)</li> </ul>
Potential Interactions of the 20 Arabidopsis thaliana Mitogen-Activated Protein Kinases (MPKs)
<p>A comprehensive dataset detailing potential interactions of the 20 <em>Arabidopsis thaliana</em> MPKs.</p>
A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew
<p>Many disease resistance genes have been introgressed into wheat from its wild relatives. However, reduced recombination within the introgressed segments hinders cloning of the introgressed genes. Here, we report the identification of wheat powdery mildew resistance gene <em>Pm13</em> originated from from <em>Aegilops longissima</em> using a method combining physical mapping with radiation-induced chromosomal aberrations and transcriptome sequencing analysis of ethyl methanesulfonate (EMS)-induced loss-of-function mutants. <em>Pm13</em> encodes a kinase fusion protein, designated MLKL-K, with an N-terminal domain of mixed lineage kinase domain-like protein (MLKL_NTD domain) and a C-terminal serine/threonine kinase domain bridged by a brace. The resistance function of <em>Pm13</em> is validated by transient and stable transgenic complementation assays. Transient over-expression analyses in <em>Nicotiana benthamiana</em> leaves and wheat protoplasts reveal that the fragment Brace-Kinase<sub>122-476</sub> of MLKL-K is capable of inducing cell death, which is dependent on a functional kinase domain and the three α-helices in the brace region close to the N-terminus of the kinase domain.</p>
MOVIE#1 -Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.
<p>Movie of paced activation acquired during perfusion of an isolated rabbit heart with CaMKII inhibitor KN93</p>
MOVIE#4 -Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.
<p>Movie of arrhythmia acquired during perfusion of an isolated rabbit heart with PKA inhibitor H89.</p>
MOVIES#1-4 -Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.
<p>Movies of paced activation and of arrhythmia acquired during perfusion of isolated rabbit hearts with CaMKII inhibitor KN93 or PKA inhibitor H89.</p>
MOVIE#3 -Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.
<p>Movie of paced activation acquired during perfusion of an isolated rabbit heart with PKA inhibitor H89</p>
MOVIE#2 -Conduction in the Right and Left Ventricle is Differentially Regulated by Protein Kinases and Phosphatases: Implications for Arrhythmogenesis.
<p>Movie of arrhythmia acquired during perfusion of an isolated rabbit heart with CaMKII inhibitor KN93.</p>
All tandem kinase proteins from 104 plant genomes
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Predicted protein-protein interactions of the human tyrosine kinase Lck by AF2Complex
<p>Structural models and Supplementary data described in the publication:</p> <p>Predicting protein interactions of the kinase Lck critical to T cell modulation</p> <p>Structure (Cell Press), 2024</p> <p>Reference Authors: Mu Gao and Jeffrey Skolnick</p> <p><br>screening_results -- Virtual PPI screening results of the protein kinase Lck (SH3-SH2 domains as the bait).<br>predicted structural models.zip -- Compressed structural models described in the publication.<br>af2c_input_features -- Input features used to predict protein complex models with AF2Complex. </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.