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268 results for “red blood cell”
The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Du
ClinicalTrials.gov study NCT01566695. IPD Sharing: Not stated. Countries: 23. Publications: 2.
Use of Pediatric Size Phlebotomy Tubes in Adult Critically Ill Patients to Reduce Red Blood Cell Transfusions
ClinicalTrials.gov study NCT03286465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia
ClinicalTrials.gov study NCT02604433. IPD Sharing: Not stated. Countries: 15. Publications: 7.
SMaRT Blood: Single-unit Versus Multiple-unit Packed Red Blood Cell Transfusion in Non-acute Postpartum Anemia
ClinicalTrials.gov study NCT03419780. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
ClinicalTrials.gov study NCT02107976. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
ClinicalTrials.gov study NCT00968227. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate Effect of a Single Dose of Sotatercept (ACE-011) on Red Blood Cell Mass and Plasma Volume in Participants With Solid Tumors
ClinicalTrials.gov study NCT01190644. IPD Sharing: YES. Countries: 1. Publications: 1.
Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic
ClinicalTrials.gov study NCT01258660. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hemoglobin-to-red Blood Cell Distribution Width Ratio and Hypothermia for Elderly Patient
ClinicalTrials.gov study NCT06790017. IPD Sharing: NO. Countries: 1. Publications: 2.
Red Blood Cell (RBC) Survival Following Transfusion in Infants
ClinicalTrials.gov study NCT00731588. IPD Sharing: NO. Countries: 1. Publications: 10.
Red Blood Cell Survival in Sickle Cell Disease
ClinicalTrials.gov study NCT04426591. IPD Sharing: YES. Countries: 1. Publications: 0.
A Safety and Efficacy Study to Evaluate Luspatercept in Subjects With Myeloproliferative Neoplasm-associated Myelofibrosis Who Have Anemia With and Without Red Blood Cell-transfusion Dependence
ClinicalTrials.gov study NCT03194542. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Age of Red Blood Cells in Premature Infants Study (ARIPI)
ClinicalTrials.gov study NCT00326924. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Evaluation of Spectra Optia Red Blood Cell Exchange in Sickle Cell Patients
ClinicalTrials.gov study NCT01736657. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery
ClinicalTrials.gov study NCT00651573. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Inferring whole-organism metabolic rate from red blood cells in birds
Open the record for dataset details and reuse information.
Data from: Elucidating the impact of red blood cell membrane components on melittin-induced pore formation with molecular dynamics simulations
Open the record for dataset details and reuse information.
Raw gel and membrane figures associated with the publication "Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells"
<p>Raw gel and membrane figures associated with the publication <strong>Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells</strong>.</p> <p> </p> <p><strong>For Figure 1a:</strong></p> <p>Raw uncropped image of the gel run with samples combining apotransferrin with iron chelators. After staining with Coomassie, gel was scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p> </p> <p><strong>For Figure 3:</strong></p> <p>Raw uncropped images of the membranes obtained from western blots of cultured erythroblasts derived from three different donors, showing the expression level of proteins involved in iron metabolism regulation (ferritin, transferrin receptor, total EIF2, phospho-EIF2). Actin was used as housekeeping protein for relative quantification of protein abundance for further analysis.</p> <p>After staining, membranes were scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p>For all membranes, the loading order is the same:</p> <p>- <strong>Day 0:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 0:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 0:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 1000 μg/mL apotransferrin</p> <p>- <strong>(empty lane)</strong></p> <p>- <strong>Day 1:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 1:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 1:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 1:</strong> 1000 μg/mL apotransferrin</p> <p>- <strong>(empty lane)</strong></p> <p>- <strong>Day 2:</strong> 1000 μg/mL holotransferrin</p> <p>- <strong>Day 2:</strong> 100 μg/mL holotransferrin</p> <p>- <strong>Day 2:</strong> 100 μg/mL holotransferrin + 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 2:</strong> 52 μM iron-loaded deferiprone</p> <p>- <strong>Day 2:</strong> 1000 μg/mL apotransferrin</p> <p>More details on the protocol for western blot available in the manuscript at https://doi.org/10.1101/2021.08.02.454758</p> <p> </p> <p><strong>For Figure 4:</strong></p> <p>Raw uncropped images of the membranes obtained from western blots of cultured erythroblasts derived from two different donors with different iron supplementations (no hTf or Def, 52 μM iron-loaded deferiprone, or 300 μg/mL holotransferrin), showing the phosphorylation level of STAT5 upon withdrawal of erythropoietin (Epo) (3 hours) and restimulation with 0.2 or 1.0 U/mL Epo.</p> <p>After staining, membranes were scanned in an Epson V500 scanner (full color, 1200 dpi, bit depth = 24).</p> <p>For both membranes, the loading order is the same:</p> <p>- <strong>Lane 1:</strong> cells cultured without hTf nor Def, and no Epo restimulation</p> <p>- <strong>Lane 2:</strong> cells cultured with 52 μM iron-loaded deferiprone, and no Epo restimulation</p> <p>- <strong>Lane 3:</strong> cells cultured with 300 μg/mL holotransferrin, and no Epo restimulation</p> <p>- <strong>Lane 4:</strong> cells cultured without hTf nor Def, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 5:</strong> cells cultured with 52 μM iron-loaded deferiprone, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 6:</strong> cells cultured with 300 μg/mL holotransferrin, and restimulation with 0.2 U/mL Epo.</p> <p>- <strong>Lane 7:</strong> cells cultured without hTf nor Def, and restimulation with 1.0 U/mL Epo.</p> <p>- <strong>Lane 8:</strong> cells cultured with 52 μM iron-loaded deferiprone, and restimulation with 1.0 U/mL Epo.</p> <p>- <strong>Lane 9:</strong> cells cultured with 300 μg/mL holotransferrin, and restimulation with 1.0 U/mL Epo.</p>
Data from: Ligation of glycophorin A generates reactive oxygen species leading to decreased red blood cell function
Acute, inflammatory conditions associated with dysregulated complement activation are characterized by significant increases in blood concentration of reactive oxygen species (ROS) and ATP. The mechanisms by which these molecules arise are not fully understood. In this study, using luminometric- and fluorescence-based methods, we show that ligation of glycophorin A (GPA) on human red blood cells (RBCs) results in a 2.1-fold, NADPH-oxidase-dependent increase in intracellular ROS that, in turn, trigger multiple downstream cascades leading to caspase-3 activation, ATP release, and increased band 3 phosphorylation. Functionally, using 2D microchannels to assess membrane deformability, GPS-ligated RBCs travel 33% slower than control RBCs, and lipid mobility was hindered by 10% using fluorescence recovery after photobleaching (FRAP). These outcomes were preventable by pretreating RBCs with cell-permeable ROS scavenger glutathione monoethyl ester (GSH-ME). Our results obtained in vitro using anti-GPA antibodies were validated using complement-altered RBCs isolated from control and septic patients. Our results suggest that during inflammatory conditions, circulating RBCs significantly contribute to capillary flow dysfunctions, and constitute an important but overlooked source of intravascular ROS and ATP, both critical mediators responsible for endothelial cell activation, microcirculation impairment, platelet activation, as well as long-term dysregulated adaptive and innate immune responses.
Microfluidic device videos of malaria infected red blood cells
<p>These videos contain malaria-infected red blood cells moving through microfluidic devices.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.