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38
datasets available to search
ShareScore release 0.9.0
Dataset results
38 results for “reverse genetics”
Next Gen(etics): targeted genome enrichment and next-generation sequencing enhances phenotype-driven forward genetics and gene-driven reverse genetics
GEO Series GSE22024. Rattus norvegicus. 30 samples. Type: Genome variation profiling by high throughput sequencing.
Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [ASO time point 2]
GEO Series GSE71234. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Embryo-scale reverse genetics at single-cell resolution
GEO Series GSE202639. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
Genetic rescue of mitochondrial complex I reverses metabolic defects in circadian mutant mice
GEO Series GSE245850. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
GEO Series GSE69687. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [ASO time point 1]
GEO Series GSE71233. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [Genetic Rescue Experiments]
GEO Series GSE71229. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides
GEO Series GSE71235. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Data from: An indexed, mapped mutant library enables reverse genetics studies of biological processes in Chlamydomonas reinhardtii
The green alga Chlamydomonas reinhardtii is a leading single-celled model for dissecting biological processes in photosynthetic eukaryotes. However, its usefulness has been limited by difficulties in obtaining mutants in genes of interest. To allow generation of large numbers of mapped mutants, we developed high-throughput methods which: (1) Enable easy propagation on agar and cryogenic maintenance of tens of thousands of C. reinhardtii strains; (2) Identify mutant insertion sites and physical coordinates in such collections; (3) Validate the insertion sites in pools of mutants by obtaining >500 bp of flanking genomic sequences. We used these approaches to construct a stably maintained library of 1,935 mapped mutants, representing disruptions in 1,562 genes. We further characterized randomly selected mutants, and found that 33 out of 44 insertion sites (75%) could be confirmed by PCR, and 17 out of 23 mutants (74%) contained a single insertion. To demonstrate the power of this library for elucidating biological processes, we analyzed the lipid content of mutants disrupted in genes encoding proteins of the algal lipid droplet proteome. This study revealed a central role of the long-chain acyl-CoA synthetase LCS2 in the production of triacylglycerol from de novo synthesized fatty acids.
Supplementary Figure S1 The scatter plots of the association between genetically predicted in the reverse MR analysis
<p>This figure described the scatter plots of the association between genetically predicted in the reverse MR analysis.</p>
Phase 1 Study of a H5N1 Influenza Vaccine (Reverse Genetic Reassortant)
ClinicalTrials.gov study NCT00783926. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: An indexed, mapped mutant library enables reverse genetics studies of biological processes in Chlamydomonas reinhardtii
Open the record for dataset details and reuse information.
Analysis of the oxidative stress regulon identifies soxS as a genetic target for resistance reversal in multi-drug resistant Klebsiella pneumoniae
GEO Series GSE146844. Klebsiella pneumoniae. 6 samples. Type: Expression profiling by high throughput sequencing.
Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
GEO Series GSE250522. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genetic Determinants of the Metabolism of Non-nucleoside Reverse Transcriptase Inhibitors
ClinicalTrials.gov study NCT00730223. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Soybean fast neutron genotyping: 700k Reverse genetics
GEO Series GSE31111. Glycine max. 11 samples. Type: Genome variation profiling by genome tiling array.
MODIFICATION OF BARLEY PLANT PRODUCTIVITY THROUGH REGULATION OF CYTOKININ CONTENT BY REVERSE-GENETICS APPROACHES
GEO Series GSE119154. Hordeum vulgare. 18 samples. Type: Expression profiling by high throughput sequencing.
Supplementary Material to Dissertation Thesis Characterization of Nipah virus in differentiated bronchial epithelial cells cultured at the air-liquid interface and Cedar virus reverse genetics
<p>Supplementary Material to Dissertation Thesis "Characterization of Nipah virus in differentiated bronchial epithelial cells cultured at the air-liquid interface and Cedar virus reverse genetics" of Martin Müller</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.