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Dataset results
467 results for “risk to development”
Eflornithine in Treating Patients At High Risk of Developing Prostate Cancer
ClinicalTrials.gov study NCT00006101. IPD Sharing: NO. Countries: 1. Publications: 1.
Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion (Part A)
ClinicalTrials.gov study NCT04555044. IPD Sharing: NO. Countries: 1. Publications: 1.
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer
ClinicalTrials.gov study NCT01276704. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
ClinicalTrials.gov study NCT00999921. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy
ClinicalTrials.gov study NCT03024996. IPD Sharing: Not stated. Countries: 28. Publications: 2.
HOMEStudy: Development of a Home-based Self-delivered Prehabilitation Intervention to Proactively Reduce Fall Risk in Older Adults
ClinicalTrials.gov study NCT05583578. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Develop
ClinicalTrials.gov study NCT05587296. IPD Sharing: NO. Countries: 16. Publications: 1.
Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy.
ClinicalTrials.gov study NCT01813721. IPD Sharing: Not stated. Countries: 11. Publications: 2.
Data from: Emerging risks of non-native species escapes from aquaculture: call for policy improvements in China and other developing countries
Open the record for dataset details and reuse information.
Using routinely available electronic health record data elements to develop and validate a digital divide risk score
Open the record for dataset details and reuse information.
Data reported in development and cross-validation of a veterans mental health risk factor screen
Open the record for dataset details and reuse information.
Data from: Prevalence of afebrile malaria and development of risk-scores for gradation of villages: a study from a hot-spot in Odisha
Introduction: Malaria is a public health emergency in India and Odisha. The national malaria elimination programme aims to expedite early identification, treatment and follow-up of malaria cases in hot-spots through a robust health system, besides focusing on efficient vector control. This study, a result of mass screening conducted in a hot-spot in Odisha, aimed to assess prevalence, identify and estimate the risks and develop a management tool for malaria elimination. Methods: Through a cross-sectional study and using WHO recommended Rapid Diagnostic Test (RDT), 13221 individuals were screened. Information about age, gender, education and health practices were collected along with blood sample (5 µl) for malaria testing. Altitude, forestation, availability of a village health worker and distance from secondary health center were captured using panel technique. A multi-level poisson regression model was used to analyze association between risk factors and prevalence of malaria, and to estimate risk scores. Results: The prevalence of malaria was 5.8% and afebrile malaria accounted for 79 percent of all confirmed cases. Higher proportion of Pv infections were afebrile (81%). We found the prevalence to be 1.38 (1.1664 - 1.6457) times higher in villages where the Accredited Social Health Activist (ASHA) didn't stay; the risk increased by 1.38 (1.0428 - 1.8272) and 1.92 (1.4428 - 2.5764) times in mid- and high-altitude tertiles. With regard to forest coverage, villages falling under mid- and highest-tertiles were 2.01 times (1.6194 - 2.5129) and 2.03 times (1.5477 - 2.6809), respectively, more likely affected by malaria. Similarly, villages of mid tertile and lowest tertile of education had 1.73 times (1.3392 - 2.2586) and 2.50 times (2.009 - 3.1244) higher prevalence of malaria. Conclusion: Presence of ASHA worker in villages, altitude, forestation, and education emerged as principal predictors of malaria infection in the study area. An easy-to-use risk-scoring system for ranking villages based on these risk factors could facilitate resource prioritization for malaria elimination.
Data from: Association between metabolic syndrome components and the risk of developing nephrolithiasis: Bayesian meta-analysis and meta-regression with dose-response analysis
<p>Nephrolithiasis has shifted to be a systemic disease. As opposed to an isolated urinary metabolic problem, it became determined that nephrolithiasis turned into considerably related to link with systemic diseases such as hypertension, obesity, dyslipidemia, and insulin resistance. The interplay between these four factors defines MetS (metabolic syndrome). In this review we aim to clarify the associations of metabolic syndrome and its components to kidney stone incident. Online databases of EMBASE, MEDLINE, and Google Scholar were searched up to October 2020 to identify observational studies examining the association between metabolic syndrome components and kidney stone incident. Bayesian Random-Effects Meta-Analysis and Meta-Regression were performed to observe the association. Linear dose-response analyses were conducted to shape the direction of the association. Data analysis was performed using STATA, and R statistics. This dataset contains supplementary material and figures as additional analysis of the study.</p>
Data from: Ear mite removal in the Santa Catalina Island fox (Urocyon littoralis catalinae): controlling risk factors for cancer development
Ear mites (Otodectes cynotis) and ear canal tumors are highly prevalent among federally endangered Island foxes (Urocyon littoralis catalinae) living on Santa Catalina Island off the coast of Southern California. Since studies began in the 1990s, nearly all foxes examined were found to be infected with ear mites, and ceruminous gland tumors (carcinomas and adenomas) were detected in approximately half of all foxes ≥ 4 years of age. We hypothesized that reduction of ear mite infection would reduce otitis externa and ceruminous gland hyperplasia, a risk factor for tumor development. In this study, we conducted a randomized field trial to assess the impact of acaricide treatment on ear mite prevalence and intensity of infection, otitis externa, ceruminous gland hyperplasia, and mite-specific IgG and IgE antibody levels. Treatment was highly effective at eliminating mites and reducing otitis externa and ceruminous gland hyperplasia, and mite-specific IgG antibody levels were significantly lower among uninfected foxes. Ceruminous gland hyperplasia increased in the chronically infected, untreated foxes during the six month study. Our results provide compelling evidence that acaricide treatment is an effective means of reducing ear mites, and that mite removal in turn reduces ear lesions and mite-specific IgG antibody levels in Santa Catalina Island foxes. This study has advanced our understanding of the underlying pathogenesis which results in ceruminous gland tumors, and has helped inform management decisions that impact species conservation.
Data from: Nest predation risk and growth strategies of passerine species: grow fast or develop traits to escape risk?
Different body components are thought to trade off in their growth and development rates, but the causes for relative prioritization of any trait remains a critical question. Offspring of species at higher risk of predation might prioritize development of locomotor traits that facilitate escaping risky environments over growth of mass. We tested this possibility in 12 altricial passerine species that differed in their risk of nest predation. We found that rates of growth and development of mass, wings, and endothermy increased with nest predation risk across species. In particular, species with higher nest predation risk exhibited relatively faster growth of wings than of mass, fledged with relatively larger wing sizes and smaller mass, and developed endothermy earlier at relatively smaller mass. This differential development can facilitate both escape from predators and survival outside of the nest environment. Tarsus growth was not differentially prioritized with respect to nest predation risk, and instead all species achieved adult tarsus size by age of fledging. We also tested whether different foraging modes (aerial, arboreal, and ground foragers) might explain the variation of differential growth of locomotor modules, but we found that little residual variation was explained. Our results suggest that differences in nest predation risk among species are associated with relative prioritization of body components to facilitate escape from the risky nest environment.
Data from: Effects of perceived predation risk and social environment on the development of three-spined stickleback (Gasterosteus aculeatus) morphology
Phenotypically plastic changes in response to variation in perceived predation risk are widespread, but little is known about if and how social environment modulates induced responses to predation risk. We investigated the influence of perceived predation risk (i.e. chemical cues from a predator) and social environment (i.e. one, two or 20 individuals reared together) on three-spined stickleback (Gasterosteus aculeatus) morphology in a factorial common garden experiment. We found that exposure to chemical cues from potential predators did not influence growth or body condition or induce more robust morphological defences (i.e. lateral plate numbers and dorsal spine lengths). However, sticklebacks exposed to predator cues developed longer caudal peduncles and larger eyes as compared with fish from the control treatment. As these responses may improve sticklebacks' ability to avoid piscine predation, they might be adaptive. Social environment/density also influenced expression of some traits, but these effects were independent of predation-risk treatment effects. In general, these results suggest that apart from the classic morphological defence structures, which appear mostly constitutive, three-spined sticklebacks are capable of expressing potentially adaptive morphological responses to chemical cues from potential predators.
Data from: Variation in offspring development is driven more by weather and maternal condition than predation risk
1. Variation in offspring development is expected to be driven by constraints on resource allocation between growth and maintenance (e.g., thermoregulation). Rapid post-natal development decreases predation risk, while inclement weather likely prolongs development. For taxa with parental care, parental behaviour may buffer offspring against some extrinsic drivers. 2. Using a 7-year dataset from an alpine population of horned lark Eremophila alpestris, a ground-nesting songbird in northern British Columbia, Canada, we investigated multiple potential drivers of variation in incubation and nestling development duration. 3. Using path analysis, we evaluated the direct effects of weather, predation risk, and parental care on offspring development, as well as, indirect developmental 'carry-over' effects of conditions during incubation on the nestling period. 4. Nestling period duration varied by nearly 100% (7–13 days) and incubation duration by 40% (10–14 days). Cold ambient temperatures late in the nestling period prolonged development by 1 day for every 2 days below 10°C; particularly when combined with heavy precipitation. Rapid nestling development was associated with high predation risk, and prolonging development incurred a nest survival cost (–2.3%/day). Females in good condition created nest environments that promoted rapid nestling development periods (average = 8–9 days) compared to poor condition females during harsh, early-season conditions (10–11 days), indicating buffering capabilities against environmental constraints. Incubation duration was only weakly correlated with fledging age (r = –0.21) suggesting minimal developmental carry-over effects. 5. Given high nest predation risk, immediate fitness benefits can be derived by overcoming environmental constraints and reducing development time. While predation risk was influential, inclement weather and maternal condition had stronger effects on within-population variation in development time. We highlight the importance of addressing multiple drivers of variation in key life-history traits and provide context for understanding life-history theory under changing environmental conditions.
Development and validation of a 36-gene sequencing assay for hereditary cancer risk assessment
<p>Sanger and MLPA datasets for the article "Development and validation of a 36-gene sequencing assay for hereditary cancer risk assessment" (http://dx.doi.org/10.1101/088252).</p>
Data and code in support of "Floating PV Reduces Risks of Hydro-Dominated Energy Development in Africa"
<p>This repository contains data and code for two experiments of floating solar capacity expansion in Africa for the paper "F<span>loating PV Reduces Risks of Hydro-Dominated </span><span>Energy Development in Africa" (Arnold et al. 2024)</span></p> <p><strong>Africa-OSeMOSYS-TEMBA</strong></p> <p>Data and code for configuring OSeMOSYS-TEMBA model scenarios with floating solar capacity expansion. The TEMBA model itself can be accessed at the Zenodo repository <em>Data in support of “Declining cost of renewables and climate change curb the need for African hydropower expansion” (2023) doi: 10.5281/zenodo.7931050</em></p> <p><strong>ZW-SAPP</strong></p> <p>Data and code for post-processing Zambezi Watercourse EMODPS / SAPP PowNet solutions and simulations.</p>
Developing an in-depth understanding of the prevalence, risk factors and treatment recommendations for phantom limb pain, and patient-generated care priorities for people who have undergone lower limb amputations.
<p>The file holds data collected for a series of four studies on phantom limb pain. </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.