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Dataset results
38 results for “senescence-associated secretory phenotype”
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
GEO Series GSE203623. Mus musculus. 66 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts
GEO Series GSE282384. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Influence of histone lysine demethylase JMJD2-specific inhibition on the senescence-associated secretory phenotype developed in human stromal cells upon DNA damage
GEO Series GSE128282. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
MLL1 is essential for the senescence-associated secretory phenotype
GEO Series GSE78142. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation
GEO Series GSE275173. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [RNA-seq]
GEO Series GSE141991. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
oHSV-mediated JAG1 blockade induces glioma senescence-associated secretory phenotype to increase macrophage activation and sensitize to cetuximab-mediated senolysis
GEO Series GSE304030. Homo sapiens; Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
oHSV-mediated JAG1 blockade induces glioma senescence-associated secretory phenotype to increase macrophage activation and sensitize to cetuximab-mediated senolysis II
GEO Series GSE303831. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [rna.M3]
GEO Series GSE159551. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
oHSV-mediated JAG1 blockade induces glioma senescence-associated secretory phenotype to increase macrophage activation and sensitize to cetuximab-mediated senolysis I
GEO Series GSE303830. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Oncogene induced senescence and senescence-associated secretory phenotype (SASP) determines the efficacy of palbociclib in PIK3CA mutated colorectal cancer
GEO Series GSE276620. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
oHSV-mediated JAG1 blockade induces glioma senescence-associated secretory phenotype to increase macrophage activation and sensitize to cetuximab-mediated senolysis III
GEO Series GSE303833. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
GEO Series GSE141994. Homo sapiens. 51 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [MeRIP-seq]
GEO Series GSE141993. Homo sapiens. 4 samples. Type: Other.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [ChIP-seq]
GEO Series GSE141992. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to the article "The microRNA-34a-induced senescence-associated secretory phenotype (SASP) favors Vascular Smooth Muscle Cells calcification"
<p>This record containsraw data related to the article"The microRNA-34a-induced senescence-associated secretory phenotype (SASP) favors Vascular Smooth Muscle Cells calcification"</p> <p>The senescence of vascular smooth muscle cells (VSMCs), characterized by the acquisition of senescence-associated secretory phenotype (SASP), is relevant for VSMCs osteoblastic differentiation and vascular calcification (VC). MicroRNA-34a (miR-34a) is a driver of such phenomena and could play a role in vascular inflammaging.</p> <p>Herein, we analyzed the relationship between miR-34a and the prototypical SASP component IL6 in <em>in vitro</em> and <em>in vivo</em> models. miR-34a and IL6 levels increased and positively correlated in aortas of 21 months-old male C57BL/6J mice and in human aortic smooth muscle cells (HASMCs) isolated from donors of different age and undergone senescence. Lentiviral overexpression of miR-34a in HASMCs enhanced IL6 secretion. HASMCs senescence and calcification accelerated after exposure to conditioned medium of miR-34a-overexpressing cells. Analysis of miR-34a-induced secretome revealed enhancement of several pro-inflammatory cytokines and chemokines, including IL6, pro-senescent growth factors and matrix-degrading molecules. Moreover, induction of aortas medial calcification and concomitant IL6 expression, with an overdose of vitamin D, were reduced in male C57BL/6J <em>Mir34a<sup>-/-</sup></em> mice. Finally, a positive correlation was observed between circulating miR-34a and IL6 in healthy subjects of 20-90 years.</p> <p>Hence, the vascular age-associated miR-34a promotes VSMCs SASP activation and contributes to arterial inflammation and dysfunctions such as VC.</p> <p> </p>
Efficacy of small molecule inhibitors and genetic interference of cGAS-STING axis on development of the senescence-associated secretory phenotype (SASP) in human stromal cells
GEO Series GSE128420. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [carRNA-m6A-seq]
GEO Series GSE159550. Homo sapiens. 8 samples. Type: Other.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.