Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
66
datasets available to search
ShareScore release 0.7.1
Dataset results
66 results for “signal diversity”
Data from: Lack of signal for the impact of conotoxin gene diversity on speciation rates in cone snails
Understanding why some groups of organisms are more diverse than others is a central goal in macroevolution. Evolvability, or the intrinsic capacity of lineages for evolutionary change, is thought to influence disparities in species diversity across taxa. Over macroevolutionary time scales, clades that exhibit high evolvability are expected to have higher speciation rates. Cone snails (family: Conidae, >900 spp.) provide a unique opportunity to test this prediction because their toxin genes can be used to characterize differences in evolvability between clades. Cone snails are carnivorous, use prey-specific venom (conotoxins) to capture prey, and the genes that encode venom are known and diversify through gene duplication. Theory predicts that higher gene diversity confers a greater potential to generate novel phenotypes for specialization and adaptation. Therefore, if conotoxin gene diversity gives rise to varying levels of evolvability, conotoxin gene diversity should be coupled with macroevolutionary speciation rates. We applied exon capture techniques to recover phylogenetic markers and conotoxin loci across 314 species, the largest venom discovery effort in a single study. We paired a reconstructed timetree using 12 fossil calibrations with species-specific estimates of conotoxin gene diversity and used trait-dependent diversification methods to test the impact of evolvability on diversification patterns. Surprisingly, we did not detect any signal for the relationship between conotoxin gene diversity and speciation rates, suggesting that venom evolution may not be the rate-limiting factor controlling diversification dynamics in Conidae. Comparative analyses showed some signal for the impact of diet and larval dispersal strategy on diversification patterns, though detection of a signal depended on the dataset and the method. If our results remain true with increased taxonomic sampling in future studies, they suggest that the rapid evolution of conid venom may cause other factors to become more critical to diversification, such as ecological opportunity or traits that promote isolation among lineages.
Data from: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals
The Myc family of transcription factors regulates a variety of biological processes, including the cell cycle, growth, proliferation, metabolism, and apoptosis. In Caenorhabditis elegans, the "Myc interaction network" consists of two opposing heterodimeric complexes with antagonistic functions in transcriptional control: the Myc-Mondo:Mlx transcriptional activation complex and the Mad:Max transcriptional repression complex. In C. elegans, Mondo, Mlx, Mad, and Max are encoded by mml-1, mxl-2, mdl-1, and mxl-1, respectively. Here we show a similar antagonistic role for the C. elegans Myc-Mondo and Mad complexes in longevity control. Loss of mml-1 or mxl-2 shortens C. elegans lifespan. In contrast, loss of mdl-1 or mxl-1 increases longevity, dependent upon MML-1:MXL-2. The MML-1:MXL-2 and MDL-1:MXL-1 complexes function in both the insulin signaling and dietary restriction pathways. Furthermore, decreased insulin-like/IGF-1 signaling (ILS) or conditions of dietary restriction increase the accumulation of MML-1, consistent with the notion that the Myc family members function as sensors of metabolic status. Additionally, we find that Myc family members are regulated by distinct mechanisms, which would allow for integrated control of gene expression from diverse signals of metabolic status. We compared putative target genes based on ChIP-sequencing data in the modENCODE project and found significant overlap in genomic DNA binding between the major effectors of ILS (DAF-16/FoxO), DR (PHA-4/FoxA), and Myc family (MDL-1/Mad/Mxd) at common target genes, which suggests that diverse signals of metabolic status converge on overlapping transcriptional programs that influence aging. Consistent with this, there is over-enrichment at these common targets for genes that function in lifespan, stress response, and carbohydrate metabolism. Additionally, we find that Myc family members are also involved in stress response and the maintenance of protein homeostasis. Collectively, these findings indicate that Myc family members integrate diverse signals of metabolic status, to coordinate overlapping metabolic and cytoprotective transcriptional programs that determine the progression of aging.
Data from: Elaborate visual and acoustic signals evolve independently in a large, phenotypically diverse radiation of songbirds
Open the record for dataset details and reuse information.
Data from: Lack of signal for the impact of conotoxin gene diversity on speciation rates in cone snails
Open the record for dataset details and reuse information.
Data from: Birdsong signals individual diversity at the major histocompatibility complex
Open the record for dataset details and reuse information.
Data from: Female preference functions drive interpopulation divergence in male signalling: call diversity in the bushcricket Ephippiger diurnus
Open the record for dataset details and reuse information.
Data from: The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals
Open the record for dataset details and reuse information.
Data from: Absence of strong signal of background selection affecting nucleotide diversity in Drosophila pseudoobscura
Open the record for dataset details and reuse information.
IL-7R signalling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells
GEO Series GSE157603. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Distinct BMP-Smad Signaling Outputs Confer Diverse Functions in Dental Mesenchyme
GEO Series GSE297138. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds
GEO Series GSE56011. Sus scrofa. 147 samples. Type: Expression profiling by array.
CTNNB1 mutations have diverse effects on signalling in Embryonic Stem Cells
GEO Series GSE299075. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
IL-33 signaling alters regulatory T cell diversity in support of tumor development
GEO Series GSE140431. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Feedback regulation of ABA signaling and biosynthesis by OsbZIP23 that targets diverse drought resistance related genes in rice
GEO Series GSE81462. Oryza sativa Japonica Group. 9 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
IL-33 signaling alters regulatory T cell diversity in support of tumor development
GEO Series GSE129914. Mus musculus. 2942 samples. Type: Expression profiling by high throughput sequencing.
Dietary ligands diindolylmethane and resveratrol result in diverse ERα signaling not seen after E2 and a subset of diindolylmethane mediated signaling needs concurrent AHR activation. [RNA-Seq]
GEO Series GSE232233. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Tumour Cell Heterogeneity Instructs Fibroblast Diversity and Reciprocal Signalling [dataset 1]
GEO Series GSE135433. Mus musculus. 64 samples. Type: Expression profiling by high throughput sequencing.
Cross-regulation between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa
GEO Series GSE64056. Pseudomonas aeruginosa UCBPP-PA14. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Distinct BMP-Smad Signaling Outputs Confer Diverse Functions in Dental Mesenchyme [RNA-seq]
GEO Series GSE297137. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Notch signaling rapidly regulates the expression of the small GTPase RND1 and a diverse endothelial transcriptome
GEO Series GSE163568. Homo sapiens; Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.