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1,884 results for “skeletal muscle”
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle
ClinicalTrials.gov study NCT03878992. IPD Sharing: NO. Countries: 1. Publications: 12.
Training Effects on Skeletal Muscle Fatty Acid Metabolism
ClinicalTrials.gov study NCT00786487. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
ClinicalTrials.gov study NCT04405180. IPD Sharing: YES. Countries: 1. Publications: 0.
Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
ClinicalTrials.gov study NCT02945553. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice
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Data from: Passive skeletal muscle can function as an osmotic engine
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Evidence for multi-scale power amplification in skeletal muscle
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Data from: Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in women with polycystic ovary syndrome
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FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis
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Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states
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Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
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Drp1 controls Complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria
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Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS
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Sex linkage of the skeletal muscle sodium channel gene (SCN4A) explains apparent deviations from Hardy–Weinberg equilibrium of tetrodotoxin-resistance alleles in garter snakes (Thamnophis sirtalis)
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Fig. 5. Correlation between the fibers diameters and body weight from 300 in Morphological and morphometric analysis of skeletal muscle between male and female young adult Colossoma macropomum (Characiformes: Serrasalmidae)
Fig. 5. Correlation between the fibers diameters and body weight from 300 days old Colossoma macropomum. The fibers diameters are showed by class: circle (<20 µm), triangle (20 to 50 µm) and square (>50 µm).
Fig. 1 in Morphological and morphometric analysis of skeletal muscle between male and female young adult Colossoma macropomum (Characiformes: Serrasalmidae)
Fig. 1. Muscle tissue organization in Colossoma macropomum. A. Multinucleated fibers with peripheral nuclei (arrow). Longitudinal section. HE. (Bar = 25 μm). B. Nuclei located at the periphery of the muscle fiber (arrow). Transverse section. HE. (Bar = 50 μm). C. Fascicle organized in perimysium and endomysium. Transverse section. HE. (Bar = 100 μm). D. Connective tissue surrounding the endomysium (dotted arrow) and perimysium (black arrow). Transverse section. Masson trichrome. (Bar = 50 μm). E. Mobilization of cells in the muscle fiber insertion in connective tissue (black arrow), many nuclei are observed. Longitudinal section. HE. (Bar = 50 μm). F. Sarcomere with striations along the muscle fiber. Longitudinal section. HE. (Bar = 25 μm).
Fig. 4 in Morphological and morphometric analysis of skeletal muscle between male and female young adult Colossoma macropomum (Characiformes: Serrasalmidae)
Fig. 4. Frequency of muscle fibers from 300 days old Colossoma macropomum. Significant differences (*) represent the differences between the animal groups according to body weight, 165 to 300 g (black) and 976 to 1,250 g (gray) in each class by ANOVA one-way supplemented by Tukey's test (P<0.05).
Fig. 3. A in Morphological and morphometric analysis of skeletal muscle between male and female young adult Colossoma macropomum (Characiformes: Serrasalmidae)
Fig. 3. A. Cellular apoptosis (black arrow). Transverse section. Masson trichrome. (Bar = 25 μm). B. Detail of the nerve (black circle). Transverse section. Masson trichrome. (Bar = 50 μm).
Up-regulation of sarcoplasmic reticulum function protects skeletal muscle against cytoplasmic calcium overload during hibernation in ground squirrels
<p>We investigated the potential mechanism of the SR in maintenance of calcium (Ca<sup>2+</sup>) homeostasis of slow-twitch muscle (soleus, SOL), fast-twitch muscle (extensor digitorum longus, EDL) and mixed muscle (gastrocnemius, GAS) in hibernating ground squirrels (<i>Spermophilus dauricus</i>). Results showed that cytosolic and SR Ca<sup>2+</sup> concentrations in distinct skeletal muscle fibers increased and decreased during late torpor, respectively, but both returned to summer-active levels during early torpor. Ryanodine receptor1 (RyR1) and sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase isoform 1 (SERCA1) protein expression increased during hibernation. Up-regulation factors of SERCA activity: Phospholamban phosphorylation increased in the SOL and GAS, β-adrenergic receptor-2 protein expression increased in the GAS, and calmodulin kinase-2 phosphorylation increased in the SOL during hibernation. Down-regulation factors of SERCA activity: Sarcolipin and SERCA1 co-localization decreased in the EDL and GAS. These data suggest that SERCA activity in skeletal muscle fibers increases likely during hibernation. FKBP12/calsequestrin1 (negative regulatory factors of RyR1) and RyR1 co-localization decreased in the GAS, indicating that the RyR1 channel opening probability increased during hibernation. Dihydropyridine receptors protein expression and its co-localization with RYR1 decreased during hibernation prompts that the contractility of skeletal muscle was weakened. Protein expression of Ca<sup>2+</sup>-binding proteins calsequestrin1 and calmodulin increased indicating that the ability of intracellular free calcium binding increased during whole hibernation period. These findings confirm that the release, uptake, and binding of free Ca<sup>2+</sup> in the SR were enhanced in different skeletal muscles during hibernation. Up-regulation of muscular sarcoplasmic reticulum function protects skeletal muscle fibers against cytoplasmic calcium overload during hibernation in ground squirrels.We investigated the potential mechanism of the SR in maintenance of calcium (Ca<sup>2+</sup>) homeostasis of slow-twitch muscle (soleus, SOL), fast-twitch muscle (extensor digitorum longus, EDL) and mixed muscle (gastrocnemius, GAS) in hibernating ground squirrels (<i>Spermophilus dauricus</i>). Results showed that cytosolic and SR Ca<sup>2+</sup> concentrations in distinct skeletal muscle fibers increased and decreased during late torpor, respectively, but both returned to summer-active levels during early torpor. Ryanodine receptor1 (RyR1) and sarco/endoplasmic reticulum Ca<sup>2+</sup> ATPase isoform 1 (SERCA1) protein expression increased during hibernation. Up-regulation factors of SERCA activity: Phospholamban phosphorylation increased in the SOL and GAS, β-adrenergic receptor-2 protein expression increased in the GAS, and calmodulin kinase-2 phosphorylation increased in the SOL during hibernation. Down-regulation factors of SERCA activity: Sarcolipin and SERCA1 co-localization decreased in the EDL and GAS. These data suggest that SERCA activity in skeletal muscle fibers increases likely during hibernation. FKBP12/calsequestrin1 (negative regulatory factors of RyR1) and RyR1 co-localization decreased in the GAS, indicating that the RyR1 channel opening probability increased during hibernation. Dihydropyridine receptors protein expression and its co-localization with RYR1 decreased during hibernation prompts that the contractility of skeletal muscle was weakened. Protein expression of Ca<sup>2+</sup>-binding proteins calsequestrin1 and calmodulin increased indicating that the ability of intracellular free calcium binding increased during whole hibernation period. These findings confirm that the release, uptake, and binding of free Ca<sup>2+</sup> in the SR were enhanced in different skeletal muscles during hibernation. Up-regulation of muscular sarcoplasmic reticulum function protects skeletal muscle fibers against cytoplasmic calcium overload during hibernation in ground squirrels.</p>
Data from: A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle
Glycolytic potential (GP) in skeletal muscle is economically important in the pig industry because of its effect on pork processing yield. We have previously mapped a major quantitative trait loci (QTL) for GP on chromosome 3 in a White Duroc × Erhualian F2 intercross. We herein performed a systems genetic analysis to identify the causal variant underlying the phenotype QTL (pQTL). We first conducted genome-wide association analyses in the F2 intercross and an F19 Sutai pig population. The QTL was then refined to an 180-kb interval based on the 2-LOD drop method. We then performed expression QTL (eQTL) mapping using muscle transcriptome data from 497 F2 animals. Within the QTL interval, only one gene (PHKG1) has a cis-eQTL that was colocolizated with pQTL peaked at the same SNP. The PHKG1 gene encodes a catalytic subunit of the phosphorylase kinase (PhK), which functions in the cascade activation of glycogen breakdown. Deep sequencing of PHKG1 revealed a point mutation (C>A) in a splice acceptor site of intron 9, resulting in a 32-bp deletion in the open reading frame and generating a premature stop codon. The aberrant transcript induces nonsense-mediated decay, leading to lower protein level and weaker enzymatic activity in affected animals. The mutation causes an increase of 43% in GP and a decrease of>20% in water-holding capacity of pork. These effects were consistent across the F2 and Sutai populations, as well as Duroc × (Landrace × Yorkshire) hybrid pigs. The unfavorable allele exists predominantly in Duroc-derived pigs. The findings provide new insights into understanding risk factors affecting glucose metabolism, and would greatly contribute to the genetic improvement of meat quality in Duroc related pigs.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.