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168 results for “susceptibility to infection”
Data from: Skin sloughing in susceptible and resistant amphibians regulates infection with a fungal pathogen
The fungal pathogen Batrachochytrium dendrobatidis (Bd) has been implicated in amphibian population declines globally. Given that Bd infection is limited to the skin in post-metamorphic amphibians, routine skin sloughing may regulate infection. Skin sloughing has been shown to reduce the number of cultivatable microbes on amphibian skin, and Bd infection increases skin sloughing rates at high loads. However, it is unclear whether species specific differences in skin sloughing patterns could regulate Bd population growth on the skin, and influence subsequent infection dynamics. We exposed five Australian frog species to Bd, and monitored sloughing rates and infection loads over time. Sloughing reduced Bd load on the ventral skin surface, in all five species, despite wide variation in susceptibility to disease. In the least susceptible species, an increase in sloughing rate occurred at lower infection loads, and sloughing reduced Bd load up to 100%, leading to infection clearance. Conversely, the drop in Bd load with sloughing was only temporary in the more susceptible species. These findings indicate that the ability of sloughing to act as an effective immune defence is species specific, and they have implications for understanding the pattern of Bd population growth on individual hosts, as well as population-level effects.
Data from: The role of habitat filtering in the leaf economics spectrum and plant susceptibility to pathogen infection
The leaf economics spectrum (LES) describes global covariation in the traits of plant leaves. The LES is thought to arise from biophysical constraints and habitat filtering (ecological selection against unfit trait combinations along environmental gradients). However, the role of habitat filtering in generating the LES has not been tested experimentally. If the process of habitat filtering plays a role in generating the LES, the LES could weaken in communities that have yet to be filtered by the current environment, for example after abiotic environmental change. LES traits are commonly used to predict community and ecosystem processes, and if the LES weakens in unfiltered communities, LES-based models may no longer apply. In the glasshouse, we experimentally simulated three stages of habitat filtering in response to abiotic change: from unfiltered, to semi-filtered, to completely filtered communities. In each stage, we quantified the strength of the LES and assessed the accuracy of trait-based models of an important ecological process, pathogen infection. The strength of the LES increased with the completeness of habitat filtering, as did the accuracy of trait-based models of plant susceptibility to pathogen infection. Synthesis. Our results suggest that habitat filtering plays a fundamental role in strengthening the trait correlations of the LES and that trait-based models may be less accurate when communities have not been filtered by the current environment, for example, following rapid environmental change.
Rapid Point-of-care Bacteriuria and Microbial Susceptibility for Women With Suspected Uncomplicated Urinary Tract Infections: Diagnostic Accuracy in General Practice.
ClinicalTrials.gov study NCT06625268. IPD Sharing: NO. Countries: 1. Publications: 2.
Detection and Characterization of Infections and Infection Susceptibility
ClinicalTrials.gov study NCT00404560. IPD Sharing: YES. Countries: 1. Publications: 4.
Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa
ClinicalTrials.gov study NCT02974348. IPD Sharing: NO. Countries: 1. Publications: 18.
14-day Susceptibility-guided Bismuth Quadruple Therapy for Multiple Drug Resistant H. Pylori Infection
ClinicalTrials.gov study NCT06687499. IPD Sharing: NO. Countries: 1. Publications: 3.
Community Antibiotic Use, Susceptibility and ResisTance Among Patients With Urinary Tract Infections (CAST-UTI)
ClinicalTrials.gov study NCT07012421. IPD Sharing: NO. Countries: 1. Publications: 8.
Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.
ClinicalTrials.gov study NCT04402827. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection
ClinicalTrials.gov study NCT05549115. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection
ClinicalTrials.gov study NCT05718609. IPD Sharing: YES. Countries: 1. Publications: 2.
The Efficacy of Susceptibility Test -Driven Sequential Therapy as the Third Line Therapy for Refractory Helicobacter Pylori Infection
ClinicalTrials.gov study NCT01032655. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Studies of Disorders With Increased Susceptibility to Fungal Infections
ClinicalTrials.gov study NCT01222741. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Susceptibility of Gambian Adults to PfSPZ-Challenge Infection in the Controlled Human Malaria Infection Model
ClinicalTrials.gov study NCT03496454. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
ClinicalTrials.gov study NCT04488458. IPD Sharing: NO. Countries: 1. Publications: 2.
Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
ClinicalTrials.gov study NCT01168271. IPD Sharing: NO. Countries: 1. Publications: 7.
Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia
ClinicalTrials.gov study NCT03357978. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Fungal Infection Susceptibility
ClinicalTrials.gov study NCT00001352. IPD Sharing: NO. Countries: 1. Publications: 15.
Bacterial and Antimicrobial Susceptibility Profile and the Prevalence of Different Sites of Infection(BASPP)
ClinicalTrials.gov study NCT03333863. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: The role of habitat filtering in the leaf economics spectrum and plant susceptibility to pathogen infection
Open the record for dataset details and reuse information.
Data from: Timing of starvation determines its effects on susceptibility to bacterial infection in female fruit flies independent of host evolutionary history
Open the record for dataset details and reuse information.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.