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292
datasets available to search
ShareScore release 0.9.0
Dataset results
292 results for “tumor metastasis”
GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis
ClinicalTrials.gov study NCT02314182. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prognostic Value of Tumor Thickness of Buccal Mucosa Squamous Cell Carcinoma on the Incidence of Nodal Metastasis.
ClinicalTrials.gov study NCT03837613. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Vaccine Therapy and Radiation to Liver Metastasis in Patients With CEA-Positive Solid Tumors
ClinicalTrials.gov study NCT00081848. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary
ClinicalTrials.gov study NCT02429570. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dataset related to article: "Heme catabolism by tumor-associated macrophages controls metastasis formation"
<p>This record contains raw data related to article "Heme catabolism by tumor-associated macrophages controls metastasis formation"</p> <p> </p> <p>Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80<sup>hi</sup>CD115<sup>hi</sup>C3aR<sup>hi</sup>CD88<sup>hi</sup>), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. This population originates from F4/80<sup>+</sup>HO-1<sup>+</sup> bone marrow (BM) precursors, accumulates in the blood of tumor bearers and preferentially localizes at the invasive margin through a mechanism dependent on the activation of Nrf2 and coordinated by the NF-κB1-CSF1R-C3aR axis. Inhibition of F4/80<sup>+</sup>HO-1<sup>+</sup> TAM recruitment or myeloid-specific deletion of HO-1 blocks metastasis formation and improves anticancer immunotherapy. Relative expression of HO-1 in peripheral monocyte subsets, as well as in tumor lesions, discriminates survival among metastatic melanoma patients. Overall, these results identify a distinct cancer-induced HO-1<sup>+</sup> myeloid subgroup as a new antimetastatic target and prognostic blood marker.</p>
Understanding tumor heterogeneity in melanoma brain metastasis using spatial transcriptomics and multi-regional bulk sequencing
<p>Melanoma brain metastasis (MBM) exhibits extensive inter- and intra-tumor heterogeneity, driven by a complex tumor microenvironment (TME). The aim with this study was to profile the MBMs by using a multi-omics approach, integrating spatial transcriptomics with bulk exome, proteome, and transcriptome profiling. We identified significant patient-specific variations in immune cell infiltration, particularly in B/plasma cells, myeloid cells, and cancer-associated fibroblasts (CAFs). Notably, immunotherapy-treated patients showed enrichedpathways related to EMT, IFN-γ signaling, oxidative phosphorylation, T-cell signaling, inflammation and DNA damage, which aligned with distinct cellular compositions observed in the spatial analysis. We also uncovered considerable intra-tumor heterogeneity, especially at the protein level, revealing differential expression patterns of key tumor and immune-related markers. The correlation between mRNA and protein data highlighted consistent enrichment of critical pathways across multi-omics layers. These findings provide a comprehensive view of MBM's molecular and cellular landscape, emphasizing the importance of addressing tumor heterogeneity in developing effective therapeutic strategies.</p>
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
ClinicalTrials.gov study NCT02669914. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomized, Prospective, Multicenter Study for the Role of Primary Tumor Resection in Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastasis
ClinicalTrials.gov study NCT01978249. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Pilot Study Assessing Intra-Metastasis Administration of Autologous KLH-pulsed Dendritic Cells With Tumoral Radiation Therapy in Patients With Metastatic Pancreatic Carcinoma
ClinicalTrials.gov study NCT00843830. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation
GEO Series GSE41892. Homo sapiens. 4 samples. Type: Expression profiling by array.
Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis.
GEO Series GSE148991. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
In vivo armed macrophages curb liver metastasis through tumor reactive T cell rejuvenation (RNA-Seq)
GEO Series GSE273613. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Contribution of crosstalk of mesothelial and tumoral epithelial cells in pleural metastasis of lung cancer
GEO Series GSE242951. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis
GEO Series GSE232359. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
CBFβ promotes colorectal tumor growth and metastasis in a RUNX2-dependent manner (ChIP-seq)
GEO Series GSE153682. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Multiomic Evaluation of Metastasis Evolution, from Primary, CTC, to Metastatic Tumors
GEO Series GSE159727. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (mouse RNA-Seq)
GEO Series GSE158502. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
ARID1A loss shapes immunosuppression tumor microenvironment via NF-kB induced MDSC chemotaxis to promote prostate Cancer metastasis [RNA-seq II]
GEO Series GSE213251. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived exosomal miR-181a-5p activates hepatic stellate cells to promote liver metastasis of colorectal cancer
GEO Series GSE141997. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
A tumor multi-region query reveals novel DNA methylation targets linked to ccRCC poor outcome and metastasis
GEO Series GSE206049. Homo sapiens. 169 samples. Type: Methylation profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.