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97 results for “virus resistance”
TDF VS LAM + ADV in LAM + ADV Treated LAM-resistant CHB Patients With Undetectable Hepatitis B Virus DNA
ClinicalTrials.gov study NCT01732367. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Genes Involved in Resistance or Susceptibility to Hepatitis B Virus
ClinicalTrials.gov study NCT00342186. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Allopolyploidy and the evolution of plant virus resistance
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Data from: New insights into the history of domesticated and wild apricots and its contribution to Plum pox virus resistance
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Data from: Resistance to RHD virus in wild Australian rabbits: comparison of susceptible and resistant individuals using a genomewide approach
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Data from: Virus resistance is not costly in a marine alga evolving under multiple environmental stressors
Viruses are important evolutionary drivers of host ecology and evolution. The marine picoplankton Ostreococcus tauri has three known resistance types that arise in response to infection with the Phycodnavirus OtV5: susceptible cells (S) that lyse following viral entry and replication; resistant cells (R) that are refractory to viral entry; and resistant producers (RP) that do not all lyse but maintain some viruses within the population. To test for evolutionary costs of maintaining antiviral resistance, we examined whether O. tauri populations composed of each resistance type differed in their evolutionary responses to several environmental drivers (lower light, lower salt, lower phosphate and a changing environment) in the absence of viruses for approximately 200 generations. We did not detect a cost of resistance as measured by life-history traits (population growth rate, cell size and cell chlorophyll content) and competitive ability. Specifically, all R and RP populations remained resistant to OtV5 lysis for the entire 200-generation experiment, whereas lysis occurred in all S populations, suggesting that resistance is not costly to maintain even when direct selection for resistance was removed, or that there could be a genetic constraint preventing return to a susceptible resistance type. Following evolution, all S population densities dropped when inoculated with OtV5, but not to zero, indicating that lysis was incomplete, and that some cells may have gained a resistance mutation over the evolution experiment. These findings suggest that maintaining resistance in the absence of viruses was not costly.
Data from: Introgression of chromosome segments from multiple alien species in wheat breeding lines with wheat streak mosaic virus resistance
Pyramiding of alien-derived Wheat streak mosaic virus (WSMV) resistance and resistance enhancing genes in wheat is a cost-effective and environmentally safe strategy for disease control. PCR-based markers and cytogenetic analysis with genomic in situ hybridisation were applied to identify alien chromatin in four genetically diverse populations of wheat (Triticum aestivum) lines incorporating chromosome segments from Thinopyrum intermedium and Secale cereale (rye). Out of 20 experimental lines, 10 carried Th. intermedium chromatin as T4DL*4Ai#2S translocations, while, unexpectedly, 7 lines were positive for alien chromatin (Th. intermedium or rye) on chromosome 1B. The newly described rye 1RS chromatin, transmitted from early in the pedigree, was associated with enhanced WSMV resistance. Under field conditions, the 1RS chromatin alone showed some resistance, while together with the Th. intermedium 4Ai#2S offered superior resistance to that demonstrated by the known resistant cultivar Mace. Most alien wheat lines carry whole chromosome arms, and it is notable that these lines showed intra-arm recombination within the 1BS arm. The translocation breakpoints between 1BS and alien chromatin fell in three categories: (i) at or near to the centromere, (ii) intercalary between markers UL-Thin5 and Xgwm1130 and (iii) towards the telomere between Xgwm0911 and Xbarc194. Labelled genomic Th. intermedium DNA hybridised to the rye 1RS chromatin under high stringency conditions, indicating the presence of shared tandem repeats among the cereals. The novel small alien fragments may explain the difficulty in developing well-adapted lines carrying Wsm1 despite improved tolerance to the virus. The results will facilitate directed chromosome engineering producing agronomically desirable WSMV-resistant germplasm.
Data from: Virus adaptation to quantitative plant resistance: erosion or breakdown?
Adaptation of populations to new environments is frequently costly due to trade-offs between life history traits, and consequently, parasites are expected to be locally adapted to sympatric hosts. Also, during adaptation to the host, an increase of parasite fitness could have direct consequences on its aggressiveness (i.e. the quantity of damages caused to the host by the virus). These two phenomena have been observed in the context of pathogen adaptation to host qualitative and monogenic resistances. However, the ability of pathogens to adapt to quantitative polygenic plant resistances and the consequences of these potential adaptations on other pathogen life history traits remain to be evaluated. Using Potato virus Y and two pepper genotypes (one susceptible and one with quantitative resistance), experimental evolutions showed that adaptation to a quantitative resistance was possible and resulted in resistance breakdown. This adaptation was associated to a fitness cost on the susceptible cultivar, but had no consequence neither in terms of aggressiveness, which could be explained by a high tolerance level, nor in terms of aphid transmission efficiency. It results that quantitative resistances are not necessarily durable but management strategies mixing susceptible and resistant cultivars in space and/or in time should be useful to preserve their efficiency.
Figure 10 in Evaluation of the Chilli veinal mottle virus CP gene expressing transgenic Nicotiana benthamiana plants for disease resistance against the virus
Figure 10. Symptoms development in transgenic plants after challenging with ChiVMV isolate ATIPK at15dpi. A) Resistance transgenic lines. B) Moderately resistance transgenic lines. C) Moderately susceptible transgenic lines.
Figure 8 in Evaluation of the Chilli veinal mottle virus CP gene expressing transgenic Nicotiana benthamiana plants for disease resistance against the virus
Figure 8. PCR products from transgenic plants. (a) Lane 1-3, represent PCR product from agro-infilterated plants. Lane 4, control plant. (b) Lane 1-9, RT- PCR product from transgenic plants represent the presence of CP gene transcription. Lane 10, represents untransformed control sample.
Figure 5 in Evaluation of the Chilli veinal mottle virus CP gene expressing transgenic Nicotiana benthamiana plants for disease resistance against the virus
Figure 5. Maximum likelihood tree of ChiVMV isolate ATIPK on nucleotide sequence of CP gene with 22 ChiVMV isolates from the world. The bootstrap analysis was conducted in 1000 replications. ZYMV (AB127936) sequence is used as out-group.
Figure 4 in Evaluation of the Chilli veinal mottle virus CP gene expressing transgenic Nicotiana benthamiana plants for disease resistance against the virus
Figure 4. RT-PCR amplification of the CP gene with CVMV1037/ oligo(dT). Lane 1, 2, 3 and 4 contains 1.2kb amplified product of NIb and CP gene.
BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma
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An Open, Multicenter Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies
ClinicalTrials.gov study NCT00002272. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus
ClinicalTrials.gov study NCT00410202. IPD Sharing: Not stated. Countries: 18. Publications: 0.
An Open Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies
ClinicalTrials.gov study NCT00002021. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Follow-up Assessment of Resistance to ABT-333 in Hepatitis C Virus (HCV)-Infected Subjects Who Have Received ABT-333 in ABT-333 Studies
ClinicalTrials.gov study NCT00726882. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Entecavir Plus Tenofovir Combination in Subjects With Multi-drug Resistant Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT01594905. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: Introgression of chromosome segments from multiple alien species in wheat breeding lines with wheat streak mosaic virus resistance
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Data from: Genetic analysis of sugarcane mosaic virus resistance in the Wisconsin Diversity Panel of maize
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International Brain Laboratory public data
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OpenNeuro
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