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Voxel-level summary statistics of hippocampus shape, white matter microstructure, and cortical surface curvature in UK Biobank (n=33,324)
<p>This deposit hosts GWAS summary statistics of hippocampus shape (n=33,324), white matter microstructure (n=33,324), and cortical surface curvature (n=15,752) using UKB unrelated white subjects. The data was generated by using the highly efficient imaging genetics (<a href="https://github.com/Zhiwen-Owen-Jiang/heig">HEIG v1.1.0</a>) framework where only the triplets - summary statistics of low-dimensional representations (LDRs), the functional bases, and the variance-covariance matrix LDRs - are shared, which is sufficient to recover all voxel-variant pairs as well as to conduct voxel-level heritability and (cross-trait) genetic correlation analysis. Check the <a href="https://github.com/Zhiwen-Owen-Jiang/heig/wiki">tutorial</a> and the <a href="../records/13770930">example data</a> used in the tutorial. </p> <p>The shared data includes:</p> <p>1. Triplets for hippocampus shape measured by the radial distance from the medial model for each vertex. The original images contain 30,000 vertices while the shared data contains 49 LDRs. Left and right hemispheres were analyzed separately, each with 15,000 vertices.</p> <p>2. Triplets for 21 white matter tracts measured by fractional anisotropy. The original images contain 32,217 voxels and each tract contains 88 ~ 3503 voxels while the shared data contains 1,034 LDRs. Tracts were analyzed separately.</p> <p>3. Triplets for cortical surface curvature. The original images contain 59,412 vertices while the shared data contains 1,750 LDRs. The entire brain was analyzed as a whole.</p> <p>4. LD matrix and its inverse for 22 chromosomes including 460k genotyped SNPs. LD matrix and its inverse were estimated by using two separate datasets each containing 8.4k white unrelated subjects in UKB. Two regularization levels are provided: {85%, 80%} for heritability and genetic correlations within images and {75%, 70%} for cross-trait genetic correlations.</p> <p>5. LD matrix and its inverse for 22 chromosomes including 1.2 million imputed HapMap3 SNPs. LD matrix and its inverse were estimated by using two separate datasets each containing 42k white unrelated subjects in UKB. Two regularization levels are provided: {98%, 95%} for heritability and genetic correlations within images and {90%, 85%} for cross-trait genetic correlations.</p>
DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours
<p>Latest description of this data set: <a href="https://github.com/MRC-Harwell/cytometer/blob/main/DATA.md">Data.md at cytometer project</a></p> <pre># Publications related to the data The data associated to the DeepCytometer project (https://github.com/MRC-Harwell/cytometer) is available from Zenodo (doi: 10.5281/zenodo.5137433 and 10.5281/zenodo.5149005). The histology and mouse measures were generated as part of the Small et al. 2018 study: > Small et al. "Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition". Nature Genetics, 50:572–580, 2018. The hand traced data set, colour maps, and automatic segmentations were generated for the Casero et al. 2021 paper: > Casero et al. "Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks". bioRxiv, 2021. doi: [10.1101/2021.06.03.444997](https://www.biorxiv.org/content/10.1101/2021.06.03.444997v1.full). # Data protocols ## Histology and laboratory measures To develop and evaluate our methods we used Klf14tm1(KOMP)Vlcg C57BL/6NTac (B6NTac) mice tissue samples and additional data generated as part of the Small et al. 2018 study(Small et al. 2018). It should be noted that the single exon Klf14 gene is imprinted and only expressed from the maternally inherited allele(Parker-Katiraee et al. 2007). This was taken into account by (Small et al. 2018) by crossing a Het parent with a WT parent, so that each offspring inherited a WT allele from the WT parent, and the Klf14 gene knockout or a WT allele from the other parent (from the father, PAT, or the mother, MAT). We also take Klf14 imprinting into account by using as controls the PAT mice and comparing them to the MAT WT and MAT Het (or functional KO, FKO) mice. We used a total of 76 Klf14-B6NTac mice (nfemale=nmale=38), of which 20 mice from the Control and FKO groups were used for training and testing the DeepCytometer pipeline, as well as the hand traced population experiment (summary in Table MICE). The histopathology screen involved fixing, processing and embedding in wax, sectioning and staining with Hematoxylin and Eosin (H&E) both inguinal subcutaneous and gonadal adipose depots. For paraffin-embedded sections, all samples were fixed in 10% neutral buffered formalin (Surgipath) for at least 48 hours at RT and processed using an Excelsior™ AS Tissue Processor (Thermo Scientific). Samples were embedded in molten paraffin wax and 8 μm sections were cut through the respective depots using a Finesse™ ME+ microtome (Thermo Scientific). Sampling was conducted at 2sxns per slide, 3 slides per depot block onto simultaneous charged slides, stained with haematoxylin Gill 3 and eosin (Thermo scientific) and scanned using an NDP NanoZoomer Digital pathology scanner (RS C10730 Series; Hamamatsu). Body weight (BW) and depot weight (DW) were measured with Satorius BAL7000 scales. ## White adipose tissue segmentation For cell area quantification, we applied DeepCytometer v8 to 75 inguinal subcutaneous and 72 gonadal whole histology slides with DeepCytometer (with the Corrected method), including the 20 slides sampled for the hand-traced data set, corresponding to 73 females and 74 males, to produce 2,560,067 subcutaneous and 2,467,686 gonadal cells (on average, 34,134 and 34,273 cells per slide, respectively). Full segmentation of all whole slides was performed with script [klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py). In this case, the segmentation contours were grouped by tiles in the output AIDA annotation `.json` file (one contour per cell, one file per slide). Non-white adipocyte contours were filtered out, and white adipocyte contours were aggregated into an AIDA annotation `.json` file with a single tile with script [klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py) (one contour per cell, one file per slide). # List of directories and files ## Casero et al. (2021) "DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours" (doi: 10.5281/zenodo.5137433) ### `deepcytometer_pipeline_v8.zip` (60.6 MB) Weights, colourmaps, etc. necessary to run the pipeline (v8, with mode colour correction). This is the version of the pipeline described in the paper. There are 10 weight files per convolutional neural network (CNN), corresponding to 10-fold cross-validation * `klf14_b6ntac_exp_0086_cnn_dmap_model_fold_[0..9].h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0089_cnn_segmentation_correction_overlapping_scaled_contours_model_fold_[0..9].h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0091_cnn_contour_after_dmap_model_fold_[0..9].h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0095_cnn_tissue_classifier_fcn_model_fold_[0..9].h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) * `klf14_b6ntac_exp_0094_generate_extra_training_images.pickle`: training dataset description * **'file_list'**: list of SVG files with hand-traced contours for network training. Each SVG file has a corresponding TIFF file with the histology used for segmentation * **'idx_test'**: 10 lists with file indices for testing in 10-fold cross-validation * **'idx_train'**: 10 lists with file indices for training in 10-fold cross-validation * **'fold_seed'**: seed number used for the random number generator to assign file indices to folds * `klf14_b6ntac_exp_0098_filename_area2quantile.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0098_full_slide_size_analysis_v7.py` using the whole Klf14 data set with v7 of the pipeline, and used in earlier experiments, including some where v8 of the pipeline was used for segmentation. * `klf14_b6ntac_exp_0106_filename_area2quantile_v8.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py` using the whole Klf14 data set with v8 of the pipeline, and used in later experiments. * `klf14_training_colour_histogram.npz`: statistics from Klf14 histology images to be used in colour correction * **'xbins_edge'**, **'xbins'**: edges and centres of the bins used for histogram calculations * **'hist_r_q1'**, **'hist_r_q2'**, **'hist_r_q3'** * **'hist_g_q1'**, **'hist_g_q2'**, **'hist_g_q3'** * **'hist_b_q1'**, **'hist_b_q2'**, **'hist_b_q3'**: density quartiles (Q1, Q2, Q3) for RGB channels for each bin the histogram * **'mode_r'**, **'mode_g'**, **'mode_b'**: modes for RGB channels (this corresponds to the most typical background colour in the histology images) * **'mean_l'**, **'mean_a'**, **'mean_b'**: mean intensity for L*a*b channels of the image * **'std_l'**, **'std_a'**, **'std_b'**: intensity standard deviations for L*a*b channels of the image * `klf14_exp_0112_training_colour_histogram.npz`: other statistics from Klf14 histology images to be used in colour correction * **'p'**: vector of quantile values used in ECDF calculations * **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'**: all intensity values for the RGB channels of Klf14 training images that contain at least a white adipocyte * **'f_ecdf_to_val_r_klf14'**, **'f_ecdf_to_val_g_klf14'**, **'f_ecdf_to_val_b_klf14'**: linear interpolation function that maps ECDF quantiles to intensity values in the Klf14 training data set. These functions can be used together with intensity->quantile interpolation functions calculated for a new histology image to perform histogram matching colour correction * **'mean_klf14'**, **'std_klf14'**: mean and standard deviation of the **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'** vectors There are also weight files for the pipeline trained with all the data, instead of the 10-fold cross-validation partition. These were not used for the paper, but could be useful for future experiments * `klf14_b6ntac_exp_0101_cnn_dmap_model.h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0104_cnn_segmentation_correction_overlapping_scaled_contours_model.h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0102_cnn_contour_after_dmap_model.h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0103_cnn_tissue_classifier_fcn_model.h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) ### `histology.7z` (29.1 GB) 165 H&E histology whole slides from Hamamatsu scanner (`.ndpi`). ### `klf14.7z` (2.3 GB) Mice metadata, training/testing data sets for the pipeline, intermediate files created during training, and neural network weights for multiple experiments. * `klf14_b6ntac_meta_info.csv`: Klf14 mice metadata * **Animal Identifier**, **id:** unique ID for each mouse * **ko_parent:** heterozygous parent of origin for the KO allele (father, PAT or mother, MAT) * **sex:** female or male * **genotype:** wild type (KLF14-KO:WT) or heterozygous (KLF14-KO:Het) * **BW:** body weight (g) * **SC:** subcutaneous depot weight (g) * **gWAT:** gonadal depot weight (g) * **Liver:** livel weight (g) * **cull_age:** age at time of culling (days) * **BW_alive:** body weight measured before culling * **BW_alive_date:** age at time of BW_alive measure * **mother:** unique ID for mouse's mother * **mother_genotype:** mouse's mother genotype * `klf14_b6ntac_training`: Directory with hand-traced segmentations of training histology windows. 131 windows sampled from 20 whole slides, plus hand-traced contours that were used for training DeepCytometer and compute population distributions. These segmentations were used for CNN training, but note that there's a cleaned-up version of these data below, and it was the cleaned-up version that was used for the paper experiments * `ndpifile_row_YYYYYY_col_XXXXXX[.tif/.xcf/.svg]`: * **ndpifile:** name of the whole slide file (e.g. `KLF14-B6NTAC 36.1c PAT 98-16 C1 - 2016-02-11 10.45.00`) * **row_YYYYYY:** Y-coordinate of the top-left corner of the sampling window, in pixels * **col_XXXXXX:** X-coordinate of the top-left corner of the sampling window, in pixels * **.tif:** TIFF file with the histology sampling window * **.xcf:** Gimp file with the histology and hand-traced contours (the contours were drawn in Gimp) * **.svg:** SVG (Scalable Vector Graphics) that contains the hand-traced contours in the XCF file * `klf14_b6ntac_training_v2`: Same as `klf14_b6ntac_training`, but the hand-traced data set was cleaned up to remove small contours of dubious cells, or cells that are fully overlapped by others * `klf14_b6ntac_training_non_overlap`: Directory with intermediate images to train the networks. These images are generated by script [`klf14_b6ntac_training_non_overlap`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0077_generate_non_overlap_training_images.py) * `klf14_b6ntac_training_augmented`: Directory with intermediate images used to train the networks (using augmentation to reduce overfitting). These images are generated by script [`klf14_b6ntac_exp_0078_generate_augmented_training_images.py`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0078_generate_augmented_training_images.py) * `klf14_b6ntac_seg`: Deprecated. Directory to store whole slide coarse segmentations in old experiments (e.g. `klf14_b6ntac_exp_0076_generate_training_images.py`). Of little interest for most users * `klf14_b6ntac_results`: Deprecated. Directory to store miscellanea output from some experiments. Of little interest for most users ## Casero et al. (2021). "Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations" (doi: 10.5281/zenodo.5149005) ### `aida_data_Klf14_v8_images.7z` (16.9 GB) Histology images converted to DeepZoom so that they can be visualised with [AIDA](https://github.com/alanaberdeen/AIDA). To use this, decompress this file and put the resulting `images` directory in your `AIDA/dist/data/` directory. ### `aida_data_Klf14_v8_annotations.7z` (18 GB) White adipocyte segmentations in AIDA annotation `.json` files (one contour per cell, one file per whole slide). Each slide has the following files: * `SLIDENAME.json`: Soft link to the annotations file that we want to associate to slide `SLIDENAME.ndpi`, e.g. `SLIDENAME` = `KLF14-B6NTAC-PAT-39.2d 454-16 B1 - 2016-03-17 12.16.06` * `SLIDENAME.lock`: Empty file used to tell the pipeline that `SLIDENAME.ndpi` has already been processed or is being currently processed * `SLIDENAME_coarse_mask.npz`: File with the coarse tissue segmentation of `SLIDENAME.ndpi` and the internal state of the pipeline (execution times, steps, etc) * `SLIDENAME_exp_0106_auto.json`: Annotations (all segmentations without filtering from the Auto algorithm, i.e. segmentation without object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_auto_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Auto algorithm. All contours aggregated into a single tile * `SLIDENAME_exp_0106_corrected.json`: Annotations (all segmentations without filtering from the Corrected algorithm, i.e. segmentation with object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_corrected_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Corrected algorithm. All contours aggregated into a single tile To use this, decompress this file and put the resulting `annotations` directory in your `AIDA/dist/data/` directory. </pre>
Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations
<p>Latest description of this data set: <a href="https://github.com/MRC-Harwell/cytometer/blob/main/DATA.md">Data.md at cytometer project</a></p> <pre># Publications related to the data The data associated to the DeepCytometer project (https://github.com/MRC-Harwell/cytometer) is available from Zenodo (doi: 10.5281/zenodo.5137433 and 10.5281/zenodo.5149005). The histology and mouse measures were generated as part of the Small et al. 2018 study: > Small et al. "Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition". Nature Genetics, 50:572–580, 2018. The hand traced data set, colour maps, and automatic segmentations were generated for the Casero et al. 2021 paper: > Casero et al. "Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks". bioRxiv, 2021. doi: [10.1101/2021.06.03.444997](https://www.biorxiv.org/content/10.1101/2021.06.03.444997v1.full). # Data protocols ## Histology and laboratory measures To develop and evaluate our methods we used Klf14tm1(KOMP)Vlcg C57BL/6NTac (B6NTac) mice tissue samples and additional data generated as part of the Small et al. 2018 study(Small et al. 2018). It should be noted that the single exon Klf14 gene is imprinted and only expressed from the maternally inherited allele(Parker-Katiraee et al. 2007). This was taken into account by (Small et al. 2018) by crossing a Het parent with a WT parent, so that each offspring inherited a WT allele from the WT parent, and the Klf14 gene knockout or a WT allele from the other parent (from the father, PAT, or the mother, MAT). We also take Klf14 imprinting into account by using as controls the PAT mice and comparing them to the MAT WT and MAT Het (or functional KO, FKO) mice. We used a total of 76 Klf14-B6NTac mice (nfemale=nmale=38), of which 20 mice from the Control and FKO groups were used for training and testing the DeepCytometer pipeline, as well as the hand traced population experiment (summary in Table MICE). The histopathology screen involved fixing, processing and embedding in wax, sectioning and staining with Hematoxylin and Eosin (H&E) both inguinal subcutaneous and gonadal adipose depots. For paraffin-embedded sections, all samples were fixed in 10% neutral buffered formalin (Surgipath) for at least 48 hours at RT and processed using an Excelsior™ AS Tissue Processor (Thermo Scientific). Samples were embedded in molten paraffin wax and 8 μm sections were cut through the respective depots using a Finesse™ ME+ microtome (Thermo Scientific). Sampling was conducted at 2sxns per slide, 3 slides per depot block onto simultaneous charged slides, stained with haematoxylin Gill 3 and eosin (Thermo scientific) and scanned using an NDP NanoZoomer Digital pathology scanner (RS C10730 Series; Hamamatsu). Body weight (BW) and depot weight (DW) were measured with Satorius BAL7000 scales. ## White adipose tissue segmentation For cell area quantification, we applied DeepCytometer v8 to 75 inguinal subcutaneous and 72 gonadal whole histology slides with DeepCytometer (with the Corrected method), including the 20 slides sampled for the hand-traced data set, corresponding to 73 females and 74 males, to produce 2,560,067 subcutaneous and 2,467,686 gonadal cells (on average, 34,134 and 34,273 cells per slide, respectively). Full segmentation of all whole slides was performed with script [klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py). In this case, the segmentation contours were grouped by tiles in the output AIDA annotation `.json` file (one contour per cell, one file per slide). Non-white adipocyte contours were filtered out, and white adipocyte contours were aggregated into an AIDA annotation `.json` file with a single tile with script [klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py) (one contour per cell, one file per slide). # List of directories and files ## Casero et al. (2021) "DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours" (doi: 10.5281/zenodo.5137433) ### `deepcytometer_pipeline_v8.zip` (60.6 MB) Weights, colourmaps, etc. necessary to run the pipeline (v8, with mode colour correction). This is the version of the pipeline described in the paper. There are 10 weight files per convolutional neural network (CNN), corresponding to 10-fold cross-validation * `klf14_b6ntac_exp_0086_cnn_dmap_model_fold_[0..9].h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0089_cnn_segmentation_correction_overlapping_scaled_contours_model_fold_[0..9].h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0091_cnn_contour_after_dmap_model_fold_[0..9].h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0095_cnn_tissue_classifier_fcn_model_fold_[0..9].h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) * `klf14_b6ntac_exp_0094_generate_extra_training_images.pickle`: training dataset description * **'file_list'**: list of SVG files with hand-traced contours for network training. Each SVG file has a corresponding TIFF file with the histology used for segmentation * **'idx_test'**: 10 lists with file indices for testing in 10-fold cross-validation * **'idx_train'**: 10 lists with file indices for training in 10-fold cross-validation * **'fold_seed'**: seed number used for the random number generator to assign file indices to folds * `klf14_b6ntac_exp_0098_filename_area2quantile.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0098_full_slide_size_analysis_v7.py` using the whole Klf14 data set with v7 of the pipeline, and used in earlier experiments, including some where v8 of the pipeline was used for segmentation. * `klf14_b6ntac_exp_0106_filename_area2quantile_v8.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py` using the whole Klf14 data set with v8 of the pipeline, and used in later experiments. * `klf14_training_colour_histogram.npz`: statistics from Klf14 histology images to be used in colour correction * **'xbins_edge'**, **'xbins'**: edges and centres of the bins used for histogram calculations * **'hist_r_q1'**, **'hist_r_q2'**, **'hist_r_q3'** * **'hist_g_q1'**, **'hist_g_q2'**, **'hist_g_q3'** * **'hist_b_q1'**, **'hist_b_q2'**, **'hist_b_q3'**: density quartiles (Q1, Q2, Q3) for RGB channels for each bin the histogram * **'mode_r'**, **'mode_g'**, **'mode_b'**: modes for RGB channels (this corresponds to the most typical background colour in the histology images) * **'mean_l'**, **'mean_a'**, **'mean_b'**: mean intensity for L*a*b channels of the image * **'std_l'**, **'std_a'**, **'std_b'**: intensity standard deviations for L*a*b channels of the image * `klf14_exp_0112_training_colour_histogram.npz`: other statistics from Klf14 histology images to be used in colour correction * **'p'**: vector of quantile values used in ECDF calculations * **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'**: all intensity values for the RGB channels of Klf14 training images that contain at least a white adipocyte * **'f_ecdf_to_val_r_klf14'**, **'f_ecdf_to_val_g_klf14'**, **'f_ecdf_to_val_b_klf14'**: linear interpolation function that maps ECDF quantiles to intensity values in the Klf14 training data set. These functions can be used together with intensity->quantile interpolation functions calculated for a new histology image to perform histogram matching colour correction * **'mean_klf14'**, **'std_klf14'**: mean and standard deviation of the **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'** vectors There are also weight files for the pipeline trained with all the data, instead of the 10-fold cross-validation partition. These were not used for the paper, but could be useful for future experiments * `klf14_b6ntac_exp_0101_cnn_dmap_model.h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0104_cnn_segmentation_correction_overlapping_scaled_contours_model.h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0102_cnn_contour_after_dmap_model.h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0103_cnn_tissue_classifier_fcn_model.h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) ### `histology.7z` (29.1 GB) 165 H&E histology whole slides from Hamamatsu scanner (`.ndpi`). ### `klf14.7z` (2.3 GB) Mice metadata, training/testing data sets for the pipeline, intermediate files created during training, and neural network weights for multiple experiments. * `klf14_b6ntac_meta_info.csv`: Klf14 mice metadata * **Animal Identifier**, **id:** unique ID for each mouse * **ko_parent:** heterozygous parent of origin for the KO allele (father, PAT or mother, MAT) * **sex:** female or male * **genotype:** wild type (KLF14-KO:WT) or heterozygous (KLF14-KO:Het) * **BW:** body weight (g) * **SC:** subcutaneous depot weight (g) * **gWAT:** gonadal depot weight (g) * **Liver:** livel weight (g) * **cull_age:** age at time of culling (days) * **BW_alive:** body weight measured before culling * **BW_alive_date:** age at time of BW_alive measure * **mother:** unique ID for mouse's mother * **mother_genotype:** mouse's mother genotype * `klf14_b6ntac_training`: Directory with hand-traced segmentations of training histology windows. 131 windows sampled from 20 whole slides, plus hand-traced contours that were used for training DeepCytometer and compute population distributions. These segmentations were used for CNN training, but note that there's a cleaned-up version of these data below, and it was the cleaned-up version that was used for the paper experiments * `ndpifile_row_YYYYYY_col_XXXXXX[.tif/.xcf/.svg]`: * **ndpifile:** name of the whole slide file (e.g. `KLF14-B6NTAC 36.1c PAT 98-16 C1 - 2016-02-11 10.45.00`) * **row_YYYYYY:** Y-coordinate of the top-left corner of the sampling window, in pixels * **col_XXXXXX:** X-coordinate of the top-left corner of the sampling window, in pixels * **.tif:** TIFF file with the histology sampling window * **.xcf:** Gimp file with the histology and hand-traced contours (the contours were drawn in Gimp) * **.svg:** SVG (Scalable Vector Graphics) that contains the hand-traced contours in the XCF file * `klf14_b6ntac_training_v2`: Same as `klf14_b6ntac_training`, but the hand-traced data set was cleaned up to remove small contours of dubious cells, or cells that are fully overlapped by others * `klf14_b6ntac_training_non_overlap`: Directory with intermediate images to train the networks. These images are generated by script [`klf14_b6ntac_training_non_overlap`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0077_generate_non_overlap_training_images.py) * `klf14_b6ntac_training_augmented`: Directory with intermediate images used to train the networks (using augmentation to reduce overfitting). These images are generated by script [`klf14_b6ntac_exp_0078_generate_augmented_training_images.py`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0078_generate_augmented_training_images.py) * `klf14_b6ntac_seg`: Deprecated. Directory to store whole slide coarse segmentations in old experiments (e.g. `klf14_b6ntac_exp_0076_generate_training_images.py`). Of little interest for most users * `klf14_b6ntac_results`: Deprecated. Directory to store miscellanea output from some experiments. Of little interest for most users ## Casero et al. (2021). "Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations" (doi: 10.5281/zenodo.5149005) ### `aida_data_Klf14_v8_images.7z` (16.9 GB) Histology images converted to DeepZoom so that they can be visualised with [AIDA](https://github.com/alanaberdeen/AIDA). To use this, decompress this file and put the resulting `images` directory in your `AIDA/dist/data/` directory. ### `aida_data_Klf14_v8_annotations.7z` (18 GB) White adipocyte segmentations in AIDA annotation `.json` files (one contour per cell, one file per whole slide). Each slide has the following files: * `SLIDENAME.json`: Soft link to the annotations file that we want to associate to slide `SLIDENAME.ndpi`, e.g. `SLIDENAME` = `KLF14-B6NTAC-PAT-39.2d 454-16 B1 - 2016-03-17 12.16.06` * `SLIDENAME.lock`: Empty file used to tell the pipeline that `SLIDENAME.ndpi` has already been processed or is being currently processed * `SLIDENAME_coarse_mask.npz`: File with the coarse tissue segmentation of `SLIDENAME.ndpi` and the internal state of the pipeline (execution times, steps, etc) * `SLIDENAME_exp_0106_auto.json`: Annotations (all segmentations without filtering from the Auto algorithm, i.e. segmentation without object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_auto_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Auto algorithm. All contours aggregated into a single tile * `SLIDENAME_exp_0106_corrected.json`: Annotations (all segmentations without filtering from the Corrected algorithm, i.e. segmentation with object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_corrected_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Corrected algorithm. All contours aggregated into a single tile To use this, decompress this file and put the resulting `annotations` directory in your `AIDA/dist/data/` directory.</pre>
Environmental data from Neversink River, White Clay Creek, and Rio Tempisquito watersheds
This dataset presents dissolved stream water chemistry and other environmental variables collected from Neversink River in NY, USA, White Clay Creek in PA, USA, and Rio Tempisquito in Costa Rica.
Permanent plot data for old-growth white pine - hemlock - hardwood forests in the Huron Mountains, Marquette County, Michigan: 2006-2022
This study was initiated by Dr. Dennis A. Riege with a focus on the role of white pine (Pinus strobus) in old-growth mixed white pine-hemlock-northern hardwood forests. Study areas within the lands of the Huron Mt. Club were selected for prominent presence of canopy white pine. Several permanent study plots, totaling about 3.3 ha, were established, with all trees >5 cm diameter at breast height (dbh) identified, mapped and measured. Initiatl establishment was from 2006-2008. All plots were remeasured in 2011, 2016 and 2021-22. Mortality and new recruits were documented in remeasurements. Reference coordinates for each plot are included in 'Methods'. Data tables in this package include all of these measurements. Additional information, including maps of downed logs, is included in material included under 'other entities'.
USFWS Larval White Sturgeon Monitoring, San Joaquin River, 2013-2017
Overview The Central Valley Project Improvement Act (CVPIA) funds habitat improvement work and associated monitoring in the Central Valley of California to increase salmonid populations in furtherance of meeting CVPIA fish doubling goals. This data package contains three datasets for larval White Sturgeon (Acipenser transmontanus) monitoring in the San Joaquin River (SJR) conducted by the US Fish and Wildlife Service, Lodi Fish and Wildlife Office. SJR_Larval_WST_Set Data This dataset contains data on an experimental sampling program using boat-mounted drift nets (D-frame nets), a large drift net attached to a stationary pontoon (pontoon net), and otter trawls to catch larval White Sturgeon in the San Joaquin River. Sets were made at targeted locations from March-July in 2013, 2015, 2016, and 2017. A total of ten White Sturgeon were captured in 2016 and 11 in 2017, all with D-frame driftnets. SJR_Larval_WST_Catch Data This dataset contains data for individual fish caught in the San Joaquin River. Species and fork length were recorded for most individuals. SJR_Fish_Taxonomy Data This dataset contains data for fish codes used in the Catch datafile. For each species that was captured, the Species codes are listed with the corresponding Interagency Ecological Program code, common name, taxonomy (Phylum, Class, Order, Family, Genus, and Species), and whether or not the species is native to the region.
USFWS Juvenile White Sturgeon Monitoring, San Joaquin River, 2016-2017
Overview The Central Valley Project Improvement Act (CVPIA) funds habitat improvement work and associated monitoring in the Central Valley of California to increase salmonid populations in furtherance of meeting CVPIA fish doubling goals. This data package contains three datasets for juvenile White Sturgeon (Acipenser transmontanus) monitoring in the San Joaquin River (SJR) conducted by the US Fish and Wildlife Service, Lodi Fish and Wildlife Office. After two years of this experimental sampling program, it was discontinued due to low catches of White Sturgeon. SJR_Juvenile_WST_Set Data This dataset contains data on an experimental sampling program using trammel nets and setlines to catch juvenile White Sturgeon in the San Joaquin River. Sets were made at targeted locations from November-January in 2016 and 2017. One White Sturgeon (1000 mm fork length) was captured in a trammel net in 2016. SJR_Juvenile_WST_Catch Data This dataset contains data for individual fish caught in trammel nets or setlines in the San Joaquin River. Species and fork length were recorded for all fish. For White Sturgeon, girth, maturation, and tag information are provided. SJR_Fish_Taxonomy Data This dataset contains data for fish codes used in the Catch datafile. For each species that was captured, the Species codes are listed with the corresponding Interagency Ecological Program code, common name, taxonomy (Phylum, Class, Order, Family, Genus, and Species), and whether or not the species is native to the region.
USFWS White Sturgeon Egg Monitoring, San Joaquin River, 2011-2018
Overview The Central Valley Project Improvement Act (CVPIA) funds habitat improvement work and associated monitoring in the Central Valley of California to increase salmonid populations in furtherance of meeting CVPIA fish doubling goals. This data package contains two datasets for White Sturgeon (Acipenser transmontanus) monitoring in the San Joaquin River (SJR) conducted by the US Fish and Wildlife Service, Lodi Fish and Wildlife Office. The objective of this sampling to was determine if White Sturgeon were spawning in the San Joaquin River and to explore where and when spawning occurred, within areas where adult White Sturgeon were known to congregate during the suspected spawning season. SJR_Egg_WST_Set Data This dataset contains data on egg mat sets used to document White Sturgeon spawning in the San Joaquin River. Sets were made at non-random locations from February to May in 2011-2018. In 2017, additional “blitz” sets were used in areas where eggs were detected. Details about set location, timing, and environmental conditions are included, along with the total number eggs of White Sturgeon and other non-sturgeon eggs. SJR_Egg_WST_Catch Data This dataset contains data specific to eggs found in egg mat nets in the San Joaquin River. Across all years, the diameter of eggs (or groups of eggs) were recorded. In 2011 and 2012, efforts were made to describe the developmental stage of White Sturgeon eggs and estimates of spawning timing were sometimes calculated.
RustMapper: White Pine Blister Rust Risk in the Western United States, 1980-2023
White pine blister rust (WPBR) is a highly destructive disease threatening high-elevation five-needle white pines across North America. To better understand risk patterns, we analyzed data from independent studies conducted across the western U.S. between 1995 and 2020. Using this data, we assessed WPBR risk for high-elevation five-needle pine species (High-5) from 1980 to 2023, integrating the results into the adaptive management tool "RustMapper." These projections estimate the annual probability of WPBR occurrence, providing valuable insights for monitoring and management. Risk ranges from 0 to 1, and values closer to 1 indicate a higher likelihood of disease occurrence based on conditions.
RustMapper: White Pine Blister Rust Risk in the Western United States, 2030-2099
White pine blister rust (WPBR) is a highly destructive disease threatening high-elevation five-needle white pines across North America. To better understand risk patterns, we analyzed data from independent studies conducted across the western U.S. between 1995 and 2020. Using this data, we assessed WPBR risk for high-elevation five-needle pine species (High-5) from 2030 to 2099, integrating the results into the adaptive management tool "RustMapper." These projections estimate the annual probability of WPBR occurrence, providing valuable insights for monitoring and management. Risk ranges from 0 to 1, and values closer to 1 indicate a higher likelihood of disease occurrence based on conditions.
Bird Abundances at the Hubbard Brook Experimental Forest (1969-present) and on three replicate plots (1986-2000) in the White Mountain National Forest (Reformatted to the ecocomDP Design Pattern)
This data package is formatted as an ecocomDP (Ecological Community Data Pattern). For more information on ecocomDP see https://github.com/EDIorg/ecocomDP. This Level 1 data package was derived from the Level 0 data package found here: https://pasta.lternet.edu/package/metadata/eml/knb-lter-hbr/81/7. The abstract below was extracted from the Level 0 data package and is included for context: Bird abundances have been determined from timed censuses, territory maps and nest locations at the Hubbard Brook Experimental Forest from 1969 to the present. This data set includes counts of the number of adult birds (males and females) per 10 ha at HBEF (1969 - present) and on three additional plots within the White Mountain National Forest (1986 - 2000). These data were gathered as part of the Hubbard Brook Ecosystem Study (HBES). The HBES is a collaborative effort at the Hubbard Brook Experimental Forest, which is operated and maintained by the USDA Forest Service, Northern Research Station.
White spruce trees tagged measured for total height and girth at 10 centimeter height, and leader length, Coldfoot, Alaska 2015, 2016
White spruce seedlings have colonized the site of the Coldfoot transplant garden (CF, 67°15′32″N, 150°10′12″W) since the original garden was established in 1982. Some trees are 2-3 meter tall. All seedlings and trees within the current (2014) garden were tagged, located with a Global Positioning System (GPS) receiver, and measured in 2015 and 2016 for total height and girth at 10 centimeter height and leader length.
Kuskokwim River Floodplain: White Spruce (Picea glauca) annual tree-ring width measurements (mm) at breast height from tree-core samples taken above Red Devil on the Kuskokwim River in July, 2007
This dataset contains annual raw ring width measurements in the Tucsan (decadal format) (.rwl file extension) of 14 large white spruce trees growing within 50m of the Kuskokwim River. Ring-widths were measured to 0.001mm on a velmex laser micrometer and accuracy was checked by crossdating using COFECHA. Annual values were measured from 1779-2006.
Biomass accumulation in trees and downed wood at Bartlett Experimental Forest, Hubbard Brook Experimental Forest, the Bowl Natural Research Area, and the White Mountain National Forest, NH, USA
Standing trees and downed wood were inventoried in all of the chronosequence stands in the White Mountains, New Hampshire to characterize biomass. Live and standing dead trees were inventoried in the chronosequence stands in 1994, 2004, 2012, and 2021. Coarse (≥ 7.6 cm diameter) and fine woody debris (3.0 – 7.6 cm) were inventoried at the same stands in 2004 and 2020. Twigs (FWD < 3.0 cm) were inventoried in 2004 and 2020. The Bowl and Mt. Pond old-growth sites were inventoried (standing trees and downed wood) in 2021.
Fluorescent Confocal Laser Scanning Microscopy of White Blood Cells, Cancer Cell Line MCF7, and Mixtures of these Cells: A Model System for Circulating Tumor Cell Biomarker Evaluation V.1
<p>This is a confocal laser scanning microscopy data set of white blood cells (leukocytes), the cancer cell line MCF7, and mixtures of these cells acquired on a Zeiss LSM 780 microscope in the University of Colorado Anschutz Medical Campus Advanced Light Microscopy Core. Cells are fluorescently labeled for DNA with DAPI (Sigma D9542), lipids with Bodipy 495/503 (Thermo Fisher D3922), the filament protein cytokeratin (CK) with pan-cytokertain-alexa555 antibodies (Cell Signaling Technologies 3478S) and the surface membrane antigen CD45 with CD45-alexa647 antibodies (Biolegend 304020). Bodipy was excited with a continuous wave (CW) 488 nm laser, alexa555 was excited with CW 561 nm laser, and alexa647 was excited with a CW 633 nm laser. The acquiring instrument does not have a CW 405 nm source so DAPI was excited by two photon process using a Coherent Cameleon ultrafast pulsed laser tuned to 765 nm. The objective used was a Zeiss Plan-Apochromat 20x, 0.8 NA, air.</p> <p>The data consists of 4 channel 8x8 mosaic z-stacks. The Zeiss software performed stitching of the mosaics. These stitched data images are included and marked with _Stitched at the end. Those interested in performing the stitching themselves can do this with the raw data files (without the _Stitched). The jpeg images are processed from the stitched LSM images. The LSM files contain additional meta data on the experiment including power levels and acquisition settings.</p> <p>The _Stiched .lsm files will load in ImageJ (tested with V.1.49) as 4 channel 3 stack images.</p> <p>This data is a model system for evaluating the DNA/Lipids/CK/CD45 biomarker panel to identify circulating tumor cells (CTCs). The D- population of the model is the WBCs and the D+ population is the MCF7 cancer cell line. The amount of separation the biomarker panel plus analysis algorithm can produce between these populations (D+/D-) is an estimate the sensitivity and specificity of the biomarker panel plus algorithm to CTCs.</p> <p>Experiments generating the data were performed over the course of 15 days. Peripheral blood samples were collected from the Gynecological Tissue and Fluid Bank (COMIRB 07-0935 / COMIRB 05-1081) from consenting patients undergoing surgery at the University of Colorado Hospital. Blood samples were used the same day they were collected. Blood samples were collected from 3 patients with benign conditions, labeled WBBN#, and 3 patients with ovarian cancer, labeled WBCA#. We do not expect there to be any difference in the isolated white blood cells samples prepared from the cancer and benign patients. Samples were stored at room temperature until white blood cells were isolated. Mixed samples were prepared by passaging a MCF7 flask and mixing it with isolated white blood cells before fixation. A schedule showing the time duration between collection, processing and imaging is included as “experimental schedule.gif”.</p> <p>The MCF7 cancer cell line was a kind gift from Dr. Heide Ford. Genomic DNA was isolated from the MCF7 cell line after the experiment and sent for cell line authentication. The gDNA was a match to MCF7. The authentication report and data are included in this submission.</p> <p>CD45 antibodies were exhausted on day 7. New antibody was purchased and received on day 8. The day 7 images only has labels for DAPI and Bodipy. The samples prepared with the old antibodies on days 4 and 7 were relabeled and imaged with the new antibodies on days 14 and 15. This labeling was also done to confirm the pan-CK antibodies remained good since they are dim in the MCF7 cells imaged on days 12 and 13. The pan-CK on days 14 and 15 looks the same as it did on days 5 and 7 confirming the antibodies are good.</p> <p>Four of the filters containing cells were not sufficiently flat to be acquired with a 3 slice z-stack so a 5 slice z-stack was used. These files have been zipped to compress them under the 2 GB limit permitted by zenodo.org</p> <p>Further information on how these samples were prepared, processed, and analyzed can be found in our associated 2016 SPIE Photonics West BIOS conference proceeding titled, “Quantitative image cytometry measurements of lipids, DNA, CD45 and cytokeratin for circulating tumor cell identification in a model system”, http://dx.doi.org/10.1117/12.2222317.</p> <p>This work was supported by funding provided to the University of Colorado Cancer Center by the American Cancer Society and awarded as Institutional Research Grant Number 57-001-53, by funding provided by the Defense Advanced Research Projects Agency under grant number N66001-10-4035, and by funding provided by NIH/NCATS Colorado CTSI Grant Number TL1 TR001081. The University of Colorado Anschutz Medical Campus Advanced Light Microscopy Core is also supported in part by NIH/NCATS Colorado CTSI Grant Number UL1 TR001082. The funders had no role in the study design, data collection, analysis, or decision to publish.</p>
Dataset accompanying Nölke et al. 2022. The choice of the white clover population alters overyielding of mixtures with perennial ryegrass and chicory and underlying processes. Scientific Reports
<p>This repository contains biomass and nitrogen yield data as well as data on diversity effects used by Nölke et al. in an article published in Scientific Reports (2022).</p> <p>Metadata are provided in the first excel worksheet ('explanation_overview'). For further details please see the original research article.</p>
Satellite tracking data of white sharks in the southwest Indian Ocean (2012-2014)
<p>These data comprise locations and individual metadata from 34 white sharks (<em>Carcharodon carcharias</em>) instrumented March-May 2012 with telemetry devices along the coast of South Africa. These devices were SPOT5 transmitters (SPOT-257, SPOT-258; Wildlife Computers) which transmit locations via ARGOS CLS. All research methods were approved and conducted under the South African Department of Environmental Affairs: Oceans and Coasts permitting authority.</p> <p>This dataset is linked to the manuscript Kock et al. 2021 "Sex and size influence the spatiotemporal distribution of white sharks, with implications for interactions with fisheries and spatial management in the southwest Indian Ocean".</p> <p>The data are structured in long format, so that each row in the dataset represents an observation. The columns in the data are as follows.</p> <p>DeployID: This a factor variable identifying each individual shark. It has 34 levels.</p> <p>SPOT: This is a numeric variable identifying the tag number unique to each shark.</p> <p>Date: This is a date variable (POSIXct) that gives the date and time of a geographic location record in UTC time.</p> <p>Type: This is a character variable identifying the type of location record.</p> <p>Quality: This is a character variable made up of numbers and letters giving the location error associated with each location as provided by ARGOS.</p> <p>Latitude: This is a numeric variable and gives the latitude of the shark at the time of each record.</p> <p>Longitude: This is a numeric variable and gives the longitude of the shark at the time of each record.</p> <p>Area_tagged: This is a character variable that gives the area where the shark was tagged.</p> <p>Sex: This is a character variable identifying the sex of the shark, either "F" or "M" for female and male.</p> <p>TL: This is a numeric variable giving the total length of the shark in centimetres.</p> <p>Maturity: This is a character variable giving the maturity of the shark based on its total length following Malcolm et al. 2001: juveniles (male and female: 175-300 cm TL), sub-adults (male: >300-360 cm TL; females: >300-480 cm TL) and adults (male: >360 cm TL; female: >480 cm TL).</p> <p> </p>
Whole-genome genotype data for French Large White pigs from two distinct sampling times
<p>Genotype data at plink binary format for 36 pigs from the french Large White breed: 13 animals from the female line born in 2014 and 2015, 13 animals from the male line born between 2012 and 2016, and 10 animals from a common ancestral line, born in 1977. These genotypes were obtained from individual whole genome sequencing (WGS) data, whiwh are available at https://www.ebi.ac.uk/ena under the accession number PRJEB51909.</p> <p>Two different genotype datasets were obtained from the raw WGS:</p> <p>1) snp20_auto_cr (.bed/bim/fam): High quality autosomal SNPs, called by 3 different software, with a call rate of at least 90%</p> <p>2) all10_auto (.bed/bim/fam): All SNPs or indels called by at least one of 3 different software.</p> <p>More details about these datasets and their use can be found in the following study:</p> <p>Boitard et al (under revision): Whole-genome sequencing of cryo-preserved resources from French Large White pigs at two distinct sampling times reveals strong signatures of convergent and divergent selection between the dam and sire lines.</p>
Gaia Catalogue of Synthetic Photometry - White Dwarfs (GCSP-WD)
<p>GSPC-WD catalogue </p> <p>This catalogue contains objects described in detail in Gaia Collaboration, Montegriffo et al., 2022, A&A, in press. The description of the catalogue from the paper is given below.</p> <p>We have made the GSPC-WD synthetic photometry available<br> as a stand-alone catalogue27, including SDSS, JKC and JPLUS<br> XPSP and the DA classification probability. The photometry<br> of the individual J-PAS bands, used in the random forest<br> analysis, is not included due to their low signal-to-noise. For<br> WDs classified in SDSS, a subset of which were used in the<br> training/validation of the random forest algorithim, we also include<br> the full SDSS classifications as a separate column in the<br> GSPC-WD catalogue table. When the synthetic spectral bands are very narrow a<br> significant number of sources will have low signal-to-noise. Furthermore,<br> at the edges of the Gaia spectral range, away from<br> the peak of the effective area, this is also true for some stars<br> in the wider bands included in the catalogue. In some extreme<br> cases, there is no significant detection of the object. The random<br> forest algorithm is only able to classify a WD when valid<br> flux measurements are available for every photometric band we<br> include in the analysis. Therefore, no classification is recorded<br> in the catalogue when data for one or more bands is "missing".<br> In total 15,003 WDs from the total sample of 101,783 are not<br> classified. For completeness, we have made all the flux measurements<br> and corresponding magnitudes available for all objects in<br> the GSPC-WD. Hence magnitude/fluxes with very large errors,<br> up to several times the flux itself, are included. However, where<br> fluxes are negative, the magnitudes are not defined. When using<br> the catalogue, appropriate signal-to-noise cuts are advisable for<br> the specific work in-hand, to ensure data quality.</p> <p>Total number of objects = 101,786; Format 1 object per row, 73 columns of data as listed below.</p> <p>Column Description of contents<br> 1 Gaia source_id<br> 2 ra<br> 3 ra_error<br> 4 dec<br> 5 dec_error<br> 6 JohnsonStd_mag_U<br> 7 JohnsonStd_mag_B<br> 8 JohnsonStd_mag_V<br> 9 JohnsonStd_mag_R<br> 10 JohnsonStd_mag_I<br> 11 JohnsonStd_flux_U<br> 12 JohnsonStd_flux_B<br> 13 JohnsonStd_flux_V<br> 14 JohnsonStd_flux_R<br> 15 JohnsonStd_flux_I<br> 16 JohnsonStd_flux_error_U<br> 17 JohnsonStd_flux_error_B<br> 18 JohnsonStd_flux_error_V<br> 19 JohnsonStd_flux_error_R<br> 20 JohnsonStd_flux_error_I<br> 21 SdssStd_mag_u<br> 22 SdssStd_mag_g<br> 23 SdssStd_mag_r<br> 24 SdssStd_mag_i<br> 25 SdssStd_mag_z<br> 26 SdssStd_flux_u<br> 27 SdssStd_flux_g<br> 28 SdssStd_flux_r<br> 29 SdssStd_flux_i<br> 30 SdssStd_flux_z<br> 31 SdssStd_flux_error_u<br> 32 SdssStd_flux_error_g<br> 33 SdssStd_flux_error_r<br> 34 SdssStd_flux_error_i<br> 35 SdssStd_flux_error_z<br> 36 Jplus_mag_uJAVA<br> 37 Jplus_mag_J0378<br> 38 Jplus_mag_J0395<br> 39 Jplus_mag_J0410<br> 40 Jplus_mag_J0430<br> 41 Jplus_mag_gJPLUS<br> 42 Jplus_mag_J0515<br> 43 Jplus_mag_rJPLUS<br> 44 Jplus_mag_J0660<br> 45 Jplus_mag_iJPLUS<br> 46 Jplus_mag_J0861<br> 47 Jplus_mag_zJPLUS<br> 48 Jplus_flux_uJAVA<br> 49 Jplus_flux_J0378<br> 50 Jplus_flux_J0395<br> 51 Jplus_flux_J0410<br> 52 Jplus_flux_J0430<br> 53 Jplus_flux_gJPLUS<br> 54 Jplus_flux_J0515<br> 55 Jplus_flux_rJPLUS<br> 56 Jplus_flux_J0660<br> 57 Jplus_flux_iJPLUS<br> 58 Jplus_flux_J0861<br> 59 Jplus_flux_zJPLUS<br> 60 Jplus_flux_error_uJAVA<br> 61 Jplus_flux_error_J0378<br> 62 Jplus_flux_error_J0395<br> 63 Jplus_flux_error_J0410<br> 64 Jplus_flux_error_J0430<br> 65 Jplus_flux_error_gJPLUS<br> 66 Jplus_flux_error_J0515<br> 67 Jplus_flux_error_rJPLUS<br> 68 Jplus_flux_error_J0660<br> 69 Jplus_flux_error_iJPLUS<br> 70 Jplus_flux_error_J0861<br> 71 Jplus_flux_error_zJPLUS<br> 72 probability DA<br> 73 SDSS WD type</p>
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs
<p>Raw data for manuscript. Contains temperature, clinical scores, qPCR, blood cell numbers and immune responses over time for two groups of pigs immunised with low virulent African swine fever virus and challenged with highly virulent virus. Data for each panel or figure is displayed on a separate worksheet in the file. The readme worksheet contains a brief description of each figure. The majority of data is displayed in an XY table format, with the number of days post immunisation with low virulent virus indicated.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.