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1,985 results for “Antigen”
Active Specific Immunotherapy for Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype Antigen Vaccines
ClinicalTrials.gov study NCT00001512. IPD Sharing: Not stated. Countries: 1. Publications: 3.
XH001 (New Antigen Tumor Vaccine) Combined With Chemotherapy as Adjuvant Therapy in Pancreatic Cancer
ClinicalTrials.gov study NCT07114666. IPD Sharing: NO. Countries: 1. Publications: 1.
Partially HLA-matched Third Party Antigen Specific T-cells for Infection Post-stem Cell or Solid Organ Transplantation
ClinicalTrials.gov study NCT02779439. IPD Sharing: NO. Countries: 1. Publications: 1.
Accuracy of the mologic COVID-19 rapid antigen test-a prospective multi-centre analytical and clinical evaluation
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Data for: Low protease activity in B cell follicles promotes retention of intact antigens after immunization
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Data from: MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans
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Data from: Evolution of antigenic diversity in the tick-transmitted bacterium Borrelia afzelii: a role for host specialization?
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N1-methylpseudouridine enhances immunogenicity of RNA/lipidnanoparticle vaccines targeting SARS-CoV-2 spike and the model antigen ovalbumin
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Data from: Global circulation patterns of seasonal influenza viruses vary with antigenic drift
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The antigen causing IgG hexamerization in patients with Chronic lymphocytic leukemia (CLL) is Alpha 2 macroglobulin (A2M)
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HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity
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Source data for: Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections
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Immunofluorescence images: Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell derived antigen
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Data from: Multiple-strain infections of borrelia afzelii: a role for within-host interactions in the maintenance of antigenic diversity?
Genetically diverse infections are common but little is known about what effects coinfecting strains have on each other in natural host-parasite systems. To explore the nature and consequences of interactions in the wild, we studied the tick-transmitted bacterium Borrelia afzelii in one of its main reservoir hosts, the bank vole Myodes glareolus. We measured overall infection intensity with quantitative polymerase chain reaction (PCR) and resolved the composition of multiple infections using strain-specific PCR assays targeting the ospC gene (which encodes an immunodominant surface protein). We found seven different strains, as defined by ospC genotype. There was little evidence for interactions affecting infection intensities, but strains were highly aggregated (i.e., there were more multiple infections than expected from random co-occurrence). Moreover, there was a positive correlation between the difference at the amino acid level between two OspC types and their degree of association. Overall, the observed patterns suggest that facilitation is more important than competition in this system and that more diverse infections have an advantage in establishing and/or maintaining infection. We propose that this advantage is one of the factors that favors antigenic diversity.
Data from: TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway
Recently we revealed that TAPBPR is a peptide exchange catalyst important for optimal peptide selection by MHC class I molecules. Here we asked if any other co-factors associate with TAPBPR which would explain its effect on peptide selection. We identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. Our results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with peptide-receptive class I molecules. We reveal that the interaction between TAPBPR and UGT1 facilities the reglucosylation of the glycan on class I, promoting their recognition by calreticulin. Our results suggest that in addition to being a peptide-editor, TAPBPR improves peptide optimisation by promoting peptide-receptive MHC class I molecules to associate with the peptide-loading complex.
Data from: Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum
Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically dependent on Fy, which binds PF4. Genetic disruption of Fy expression inhibits binding of PF4 to parasitized cells and concomitantly prevents parasite killing by both human platelets and recombinant human PF4. The protective function afforded by platelets during a malarial infection may therefore be compromised in Duffy-negative individuals, who do not express Fy.
Data from: Chimeric antigen receptors that trigger phagocytosis
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may be beneficial. Here, we engineered a family of Chimeric Antigen Receptors for Phagocytosis (CAR-Ps) that direct macrophages to engulf specific targets, including cancer cells. CAR-Ps consist of an extracellular antibody fragment, which can be modified to direct CAR-P activity towards specific antigens. By screening a panel of engulfment receptor intracellular domains, we found that the cytosolic domains from Megf10 and FcRɣ robustly triggered engulfment independently of their native extracellular domain. We show that CAR-Ps drive specific engulfment of antigen-coated synthetic particles and whole human cancer cells. Addition of a tandem PI3K recruitment domain increased cancer cell engulfment. Finally, we show that CAR-P expressing murine macrophages reduce cancer cell number in co-culture by over 40%.
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
<p>Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. This approach may still be limited by the presence of immunosuppressive myeloid populations. Here we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. Treatment of xenograft tumors resulted in PD-L1 dependent tumor growth inhibition. PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. The clinical study of PD-L1 CAR haNKs is warranted.</p>
Supplemental Data: Discrete LAT condensates encode antigen information from single pMHC:TCR binding events
<p>Microscopy data and associated code for analysis. For more information refer to https://doi.org/10.1038/s41467-022-35093-9</p>
Multi-antigen imaging data of skin tissue samples from melanoma and benign nevi
<h2><strong>Data</strong></h2> <p>Multi-antigen imaging data with 182 skin tissue samples:</p> <table> <tbody> <tr> <td>Condition</td> <td>PFS</td> <td>Number of patients</td> <td>Number of MELC images</td> </tr> <tr> <td>Melanoma</td> <td>PFS >=5</td> <td>14</td> <td>97</td> </tr> <tr> <td>Melanoma</td> <td>PFS < 5</td> <td>8</td> <td>15</td> </tr> <tr> <td>Melanoma</td> <td>NA</td> <td>5</td> <td>13</td> </tr> <tr> <td>Benign nevi</td> <td>-</td> <td>12</td> <td>57</td> </tr> </tbody> </table> <p>Patients were treated at the University Hospital Erlangen. Each sample contains around 50 protein channels, each of resolution 512 X 512 pixels. The data were generated using multi-epitope ligand cartography (MELC) (https://doi.org/10.1038/nbt1250, https://doi.org/10.1007/3-540-36459-5_8).</p> <h2>Metadata</h2> <p>For each MELC image, the table contains the corresponding section and patient ID, sex, age, and which group (melanoma or nevus) it belongs to. For most of the melanoma samples, the data contains the information, whether the patient had progression free survival (PFS) of 5 years, the tumor thickness, whether the tumor is ulcerated and its coarse location (0: thoraric, 1: abdominal, 2: back, 3: arm, 4: leg) and side (right: -1, left: 1). Furthermore, we annotate if we could produce a high-quality segmentation result.</p> <h2>Model weights</h2> <p>We provide the pre-trained model as well as the fine-tuned models. Please be aware that we initalize the model before pre-training with the weights provided here https://github.com/ozanciga/self-supervised-histopathology/releases/tag/tenpercent (Ciga, O., Xu, T., and Martel, A. L. (2022). Self supervised contrastive learning for digital histopathology. Machine Learning with Applications 7, 100198).</p> <h2>Anndata file</h2> <p>We provide an anndata file with cell-level protein abundance and assigned cell types.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.