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418
datasets available to search
ShareScore release 0.9.0
Dataset results
418 results for “Dimerization”
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [ChIP-seq]
GEO Series GSE220962. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
NOTCH dimerization contributes to maintenance of intestinal homeostasis
GEO Series GSE262485. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
ChIPseq identification of DDIT3 genomic binding sites - correlations with gene expression data reveal dimerization partners and target genes
GEO Series GSE153869. Homo sapiens. 44 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq III)
GEO Series GSE189913. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [RNA-seq]
GEO Series GSE220963. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (CLIP-Seq)
GEO Series GSE189911. Homo sapiens. 6 samples. Type: Other.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program
GEO Series GSE220966. Mus musculus. 83 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other.
Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq II)
GEO Series GSE189912. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [WES]
GEO Series GSE220964. Mus musculus. 28 samples. Type: Other.
Simulations of PKA RIα Homodimer Reveal cAMP-coupled Conformational Dynamics of Each Protomer and the Dimer Interface with Functional Implications
<p>Protein kinase A (PKA) is a ubiquitous cAMP-dependent enzyme in mammalian tissues. The inactive PKA holoenzyme disassociates into a homodimer of regulatory (R) subunits and two active catalytic (C) subunits upon cAMP binding to two tandem domains (termed <span>CBD-A</span> <span>and</span> <span>CBD</span>-<span>B</span>) in R subunits. The release of cAMP facilitates reassociation of R and C subunits<span>,</span> resetting PKA to its basal state. The cAMP-mediated structural changes in the activation-termination cycle <span>remain</span> <span>partially</span> <span>understood</span>. The multimeric states of PKA complicate the issue and are particularly <span>less</span> <span>studied</span>. Therefore, we computationally investigate the conformational dynamics of PKA <span>RI</span>a homodimer in different cAMP-bound states. The absence of cAMP in two CBDs affect differently the <span>conformational</span> <span>dynamics</span> of protomers. Moreover, <span>such</span> disparate <span>responses</span> are extended to the dimer interface <span>constituted</span> <span>by</span> <span>the</span> <span>N</span>-<span>terminal</span> <span>helical</span> <span>sub-domains</span> termed N3A motifs. T<span>he removal of cAMP from CBD-A induces large-scale structure</span> changes <span>of individual </span>R subunits <span>towards the holoenzyme state,</span> consist with previous simulations of a single R subunit. <span>Meanwhile</span> <span>it</span> <span>keeps the structural heterogeneity of the </span>N3A-N3A' <span>dimer interface observed in the fully bound state.</span> By contrast, the removal of cAMP from CBD-B does not affect <span>individual </span>R subunits but alters the conformational space of the N3A-N3A' dimer interface. The cAMP-coupled s<span>tructural</span> <span>changes</span> <span>of</span> <span>each</span> <span>protomer</span> <span>and</span> conserved conformational space of <span>the</span> N3A-N3A' <span>dimer</span> <span>interface</span> are essential for t<span>he</span> <span>transition</span> <span>between</span> the fully cAMP-bound R<sub>2</sub> homodimer and the R<sub>2</sub>C<sub>2</sub> holoenzyme as suggested by their crystal structures. Our work provides structural insights into <span>the</span> regulatory mechanism of cAMP in PKA signaling. </p>
Fig. 4 in Sesquiterpenoids and sesquiterpenoid dimers from the stem bark of Dysoxylum parasiticum (osbeck) kosterm
Fig. 4. Experimental and calculated ECD spectra of 1–5.
Fig. 5 in Targeted isolation of sesquiterpene lactone dimers from Aucklandia lappa guided by LC-HRMS/MS-based molecular networking
Fig. 5. Putative biogenetic pathway of compounds 1–6.
RNA-seq analysis of CREB3L2 dimers in Hippocampal Neurons
GEO Series GSE169185. Rattus norvegicus. 15 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [scRNA-seq]
GEO Series GSE220965. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (ChIP-Seq)
GEO Series GSE189910. Homo sapiens. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Set1 complex is dimeric and acts with Proof Only Jhd2 demethylation to convey symmetrical H3K4 trimethylation [Spike-in-ChIP-seq]
GEO Series GSE127841. Saccharomyces cerevisiae; Schizosaccharomyces pombe. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Set1 complex is dimeric and acts with Proof Only Jhd2 demethylation to convey symmetrical H3K4 trimethylation [ChIP-seq]
GEO Series GSE127842. Saccharomyces cerevisiae. 42 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Set1 complex is dimeric and acts with Proof Only Jhd2 demethylation to convey symmetrical H3K4 trimethylation
GEO Series GSE127843. Schizosaccharomyces pombe; Saccharomyces cerevisiae. 90 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model.
GEO Series GSE165387. Homo sapiens; Mus musculus. 12 samples. Type: Expression profiling by array.
Oleanolic acid inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by promoting iNOS dimerization
GEO Series GSE120311. Homo sapiens. 2 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.