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857
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ShareScore release 0.9.0
Dataset results
857 results for “alternative splicing;”
Intronic Non-CG DNA Hydroxymethylation and Alternative mRNA Splicing in Honey Bees
GEO Series GSE50990. Apis mellifera; Apis mellifera scutellata. 8 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Alternative mRNA splicing in human epidermal differentiation
GEO Series GSE201094. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Control of Neuronal Synapse Specification by a Highly Dedicated Alternative Splicing program
GEO Series GSE79902. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Alternative splicing decouples local from global PRC2 activity
GEO Series GSE223666. Mus musculus. 87 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
VastDB: an Atlas of Alternative Splicing Profiles in Vertebrate Tissues and Cell Types
GEO Series GSE90957. Gallus gallus. 3 samples. Type: Expression profiling by high throughput sequencing.
Asian Zika virus isolate significantly changes the transcriptional profile and alternative RNA splicing events in a neuroblastoma cell line
GEO Series GSE149775. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
RPL8 extensively regulates the expression and alternative splicing of cancer-related genes
GEO Series GSE161696. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
A Ralstonia solanacearum effector targets splicing factor SR34a to reprograms alternative splicing and regulates host immunity
GEO Series GSE276633. Solanum lycopersicum. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of CLK2 overexpression on alternative splicing
GEO Series GSE227673. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: Rapid and dynamic alternative splicing impacts the Arabidopsis cold response transcriptome
Plants have adapted to tolerate and survive constantly changing environmental conditions by re-programming gene expression. The dynamics of the contribution of alternative splicing (AS) to stress responses are unknown. RNA-sequencing of a time-series of Arabidopsis thaliana plants exposed to cold determines the timing of significant AS changes. This shows a massive and rapid AS response with coincident waves of transcriptional and AS activity occurring in the first few hours of temperature reduction, and further AS throughout the cold. In particular, hundreds of genes showed changes in expression due to rapidly occurring AS in response to cold ("early AS" genes); these included numerous novel cold-responsive transcription factors and splicing factors/RNA-binding proteins regulated only by AS. The speed and sensitivity to small temperature changes of AS of some of these genes suggest that fine-tuning expression via AS pathways contributes to the thermo-plasticity of expression. Four "early AS" splicing regulatory genes have been shown previously to be required for freezing tolerance and acclimation; we provide evidence of a fifth gene, U2B"-LIKE. Such factors likely drive cascades of AS of downstream genes which alongside transcription modulate transcriptome reprogramming that together govern the physiological and survival responses of plants to low temperature.
Data from: Genome-wide analysis of alternative splicing landscapes modulated during plant-virus interactions in Brachypodium distachyon
In eukaryotes, alternative splicing (AS) promotes transcriptome and proteome diversity. The extent of genome-wide AS changes occurring during a plant-microbe interaction is largely unknown. Here, using high-throughput, paired-end RNA sequencing, we generated an isoform-level spliceome map of Brachypodium distachyon infected with Panicum mosaic virus and its satellite virus. Overall, we detected ∼44,443 transcripts in B. distachyon, ∼30% more than those annotated in the reference genome. Expression of ∼28,900 transcripts was ≥2 fragments per kilobase of transcript per million mapped fragments, and ∼42% of multi-exonic genes were alternatively spliced. Comparative analysis of AS patterns in B. distachyon, rice (Oryza sativa), maize (Zea mays), sorghum (Sorghum bicolor), Arabidopsis thaliana, potato (Solanum tuberosum), Medicago truncatula, and poplar (Populus trichocarpa) revealed conserved ratios of the AS types between monocots and dicots. Virus infection quantitatively altered AS events in Brachypodium with little effect on the AS ratios. We discovered AS events for >100 immune-related genes encoding receptor-like kinases, NB-LRR resistance proteins, transcription factors, RNA silencing, and splicing-associated proteins. Cloning and molecular characterization of SCL33, a serine/arginine-rich splicing factor, identified multiple novel intron-retaining splice variants that are developmentally regulated and modulated during virus infection. B. distachyon SCL33 splicing patterns are also strikingly conserved compared with a distant Arabidopsis SCL33 ortholog. This analysis provides new insights into AS landscapes conserved among monocots and dicots and uncovered AS events in plant defense-related genes.
Race-related Alternative Splicing: Novel Targets in Prostate Cancer
ClinicalTrials.gov study NCT03424213. IPD Sharing: NO. Countries: 1. Publications: 0.
Alternative Splicing and Leukemia Initiating Cells
ClinicalTrials.gov study NCT03156933. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing
ClinicalTrials.gov study NCT01349387. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [RNA-Seq]
GEO Series GSE31486. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Defects in the alternative splicing-dependent regulation of REST cause deafness - [mouse brain cortex].
GEO Series GSE111602. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
SF3B6 promotes the cellular proliferation by extensively interacting with and regulating transcripts expression and alternative splicing in MDA-MB-231 cells [RNA-seq]
GEO Series GSE295603. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
p38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress
GEO Series GSE117699. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome
GEO Series GSE11892. Homo sapiens. 11 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single-cell Architecture and Functional Requirement of Alternative Splicing during Hematopoietic Stem Cell Emergence
GEO Series GSE185555. Mus musculus. 95 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.