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388
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ShareScore release 0.9.0
Dataset results
388 results for “immune checkpoint inhibitors”
A β-1,3/1,6-glucan from Durvillaea Antarctica enhances anti-tumor effects of immune checkpoint inhibitor antibodies
GEO Series GSE241125. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
SLC6A3 Dopaminergic Signaling Subverts Spliceosomal Fidelity to Promote Immune Checkpoint Inhibitor Resistance in Clear Cell Renal Cell Carcinoma [2]
GEO Series GSE316470. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A β-1,3/1,6-glucan from Durvillaea Antarctica enhances anti-tumor effects of immune checkpoint inhibitor antibodies II
GEO Series GSE242577. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer [CHIP-seq]
GEO Series GSE196324. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
SLC6A3 Dopaminergic Signaling Subverts Spliceosomal Fidelity to Promote Immune Checkpoint Inhibitor Resistance in Clear Cell Renal Cell Carcinoma [1]
GEO Series GSE316468. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Hepatotoxicity in Patients with Hepatocellular Carcinoma on Treatment with Immune Checkpoint Inhibitors"
<p>This record contains raw data related to article "Hepatotoxicity in Patients with Hepatocellular Carcinoma on Treatment with Immune Checkpoint Inhibitors"</p> <p>Risk factors for hepatic immune-related adverse events (HIRAEs) in patients with advanced/unresectable hepatocellular carcinoma (HCC) treated with immune checkpoint inhibitors (ICIs) are unclear. We investigated: (i) clinical and morpho-pathological predictors of HIRAEs in 27 pretreatment tumor specimens, including surrogate biomarkers of the HCC immune class (based on intratumoral tertiary lymphoid structures, and glutamine synthase, CD3, and CD79 expression); and (ii) the relationship between HIRAE onset and subsequent treatment outcomes. Fifty-eight patients were included-20 (34%) received ICIs alone, and 38 (66%) received ICIs plus targeted agents as first- or further-line treatment. After a median time of 0.9 months (range, 0.4-2.7), nine patients (15.5%) developed grade ≥ 3 hepatitis, which was significantly associated with higher baseline ALT levels (<em>p</em> = 0.037), and an infectious HCC etiology (<em>p</em> = 0.023). ICIs were safely resumed in six out of nine patients. Time to treatment failure (TTF) was not significantly different in patients developing grade ≥ 3 hepatitis vs. lower grades (3.25 vs. 3.91 months, respectively; <em>p</em> = 0.81). Biomarker surrogates for the HCC immune class were not detected in patients developing grade ≥ 3 hepatitis. Grade ≥ 3 hepatitis has a benign course that does not preclude safe ICI reintroduction, without any detrimental effect on TTF.</p>
Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer.
GEO Series GSE196325. Mus musculus; Homo sapiens. 59 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I"
<p>This record contains raw data (metabolomic and RNASeq data) related to the article: "Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I"</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.