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1,201 results for “oncology”
The Effect of Chewing Gum and Hot Compresses on Gynecologic Oncologic Surgery
ClinicalTrials.gov study NCT06196138. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Improvement of Self Management for Oncologic Patients With Pain
ClinicalTrials.gov study NCT00779597. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A practical approach to febrile cancer patients: Diagnostic stewardship in Oncology units
Open the record for dataset details and reuse information.
Data from: A virtual molecular tumor board platform to improve efficiency and scalability of delivering precision oncology to physicians and their patients
OBJECTIVES: Scalable informatics solutions that provide molecularly-tailored treatment recommendations to clinicians are needed to streamline Precision Oncology in care settings. MATERIALS AND METHODS: We developed a cloud-based virtual molecular tumor board (VMTB) platform that included a knowledgebase, scoring model, rules engine, an asynchronous virtual chat room and a reporting tool that generated a treatment plan for each of the 1725 patients based on their molecular profile, previous treatment history, structured trial eligibility criteria, clinically relevant cancer gene-variant assertions, biomarker-treatment associations, and current treatment guidelines. The VMTB systematically allows clinician users to combine expert-curated data and structured data from clinical charts along with molecular testing data to develop consensus on treatments, especially those that require off-label and clinical trial considerations. RESULTS: The VMTB was used as part of the cancer care process for a focused subset of 1725 patients referred by advocacy organizations wherein resultant personalized reports were successfully delivered to treating oncologists. Median turnaround time from data receipt to report delivery decreased from 14 days to 4 days over 4 years while the volume of cases increased nearly twofold each year. Using a novel scoring model for ranking therapy options, oncologists chose to implement the VMTB-derived therapies over others, except when pursuing immunotherapy options without molecular support. DISCUSSION: VMTBs will play an increasingly critical role in precision oncology as the compendium of biomarkers and associated therapy options available to a patient continues to expand. CONCLUSION: Further development of such clinical augmentation tools that systematically combine patient-derived molecular data, real world evidence from electronic health records, and expert curated knowledgebases on biomarkers with computational tools for ranking best treatments can support care pathways at point of care.
Data from: Current management of surgical oncologic emergencies
Objectives: For some oncologic emergencies, surgical interventions are necessary for dissolution or temporary relieve. In the absence of guidelines, the most optimal method for decision making would be in a multidisciplinary cancer conference (MCC). In an acute setting, the opportunity for multidisciplinary discussion is often not available. In this study, the management and short term outcome of patients after surgical oncologic emergency consultation was analyzed. Method: A prospective registration and follow up of adult patients with surgical oncologic emergencies between 01-11-2013 and 30-04-2014. The follow up period was 30 days. Results: In total, 207 patients with surgical oncologic emergencies were included. Postoperative wound infections, malignant obstruction, and clinical deterioration due to progressive disease were the most frequent conditions for surgical oncologic emergency consultation. During the follow up period, 40% of patients underwent surgery. The median number of involved medical specialties was two. Only 30% of all patients were discussed in a MCC within 30 days after emergency consultation, and only 41% of the patients who underwent surgery were discussed in a MCC. For 79% of these patients, the surgical procedure was performed before the MCC. Mortality within 30 days was 13%. Conclusion: In most cases, surgery occurred without discussing the patient in a MCC, regardless of the fact that multiple medical specialties were involved in the treatment process. There is a need for prognostic aids and acute oncology pathways with structural multidisciplinary management. These will provide in faster institution of the most appropriate personalized cancer care, and prevent unnecessary investigations or invasive therapy.
Data from: Oncological and surgical outcome after treatment of pelvic sarcomas
Background and Objectives. Treatment of pelvic tumors remains challenging due to complex anatomy, poor oncological outcome and high complication rates. We sought to investigate the long-term oncological and surgical outcome of these patients. Methods. Between 1980 and 2012, 147 patients underwent surgical treatment for pelvic sarcoma. Histological diagnosis was Chondrosarcoma in 54, Ewing's Sarcoma/PNET in 37, Osterosarcoma in 32 and others in 24 patients. Statistical analysis for the evaluation of oncological and surgical outcome was performed by applying Cox proportional hazards regression and Fine-Gray regression models for competing risk (CR) endpoints. Results. The estimated overall survival (OS) to death was 80%, 45% and 37% at 1, 5 and 10 years, respectively. Univariate analyses revealed a statistically significant unadjusted influence of age age (p=0.038; HR=1.01), margin (p=0.043; HR=0.51) and grade (p=0.001; HR=2.27) on OS. Considering the multivariable model, grade (p=0.005; HR=3.04) and tumor volume (p=0.014; HR=1.18) presented themselves as independent prognostic factors on OS. CR analysis showed a cumulative incidence for major complication of 31% at 5 years. Endoprosthetic reconstruction had a higher risk for experiencing a major complication (p<0.0001) and infection (p=0.001). Conclusions. Pelvic resections are still associated with a high incidence of complications. Patients with pelvic reconstruction and high volume tumors are especially at risk. Consequently, a cautious decision-making process is necessary when indicating pelvic reconstruction, although a restrictive approach to pelvic reconstruction is not necessarily reasonable when the other option is major amputation.
"Narrative Interview" intervention in Oncology: Qualitative and Quantitative Data
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Oral active matrix metalloproteinase-8 immunotest may be less accurate in haemato-oncologic patients
<p>Dataset of the corresponding study</p>
Gender perspective in oncology research
<p>Gender bias in oncology research</p>
The Effect of Unfavorable Histological Features on the Oncological Outcomes of Colon Cancer
ClinicalTrials.gov study NCT03794193. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Psychological Care of Oncology Patients With Post-traumatic Stress in the Context of a COVID-19
ClinicalTrials.gov study NCT04747249. IPD Sharing: NO. Countries: 1. Publications: 0.
BrUOG 295: Adjuvant FOLFOX-A For Resected Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial
ClinicalTrials.gov study NCT02022033. IPD Sharing: NO. Countries: 1. Publications: 0.
Feasibility of Aspirate Tissue Monitoring in Neuro-oncological Surgery
ClinicalTrials.gov study NCT06740097. IPD Sharing: NO. Countries: 2. Publications: 0.
C14 Study in Oncology Patients With Advanced and/or Metastatic Solid Tumors
ClinicalTrials.gov study NCT01296568. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nutritional Intervention-induced Weight Loss During the Oncological Treatment of Obesity-related Breast Cancer
ClinicalTrials.gov study NCT06046755. IPD Sharing: NO. Countries: 0. Publications: 8.
Comparison of Surgical,Clinical and Oncological Outcomes Between Robotic-assisted and Laparoscopic-assisted Gastrectomy
ClinicalTrials.gov study NCT02413476. IPD Sharing: Not stated. Countries: 0. Publications: 16.
TIPOPS (Telemedicine vs In Person Oncology Patient Surveillance)
ClinicalTrials.gov study NCT04936243. IPD Sharing: YES. Countries: 1. Publications: 0.
Osteopathic Manipulative Treatment in Oncology Patients' Management
ClinicalTrials.gov study NCT03142386. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Impact of Early Mobility on Post-Surgery Recovery in Patients Undergoing Oncologic Surgeries
ClinicalTrials.gov study NCT04000581. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating the Implementation of a Comprehensive Multilevel Virtual Oncology Program Among Veterans Diagnosed With Lung, Colorectal, Prostate, and Breast Cancers in the US Department of Veterans Affai
ClinicalTrials.gov study NCT06559059. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.