Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
836
datasets available to search
ShareScore release 0.9.0
Dataset results
836 results for “Acute Kidney Injury”
Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery
GEO Series GSE197272. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice
C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. Impaired autophagy is known to exacerbate renal ischemia-reperfusion injury (IRI). We examined whether the pathogenic role of CRP in AKI is associated with reduction of autophagy. We mated transgenic rabbit CRP over-expressing mice (Tg-CRP) with two autophagy reporter mouse lines, Tg-GFP-LC3 mice (LC3) and Tg-RFP-GFP-LC3 mice (RG-LC3) respectively to generate Tg-CRP-GFP-LC3 mice (PLC3) and Tg-CRP-RFP-GFP-LC3 mice (PRG-LC3). AKI was induced by IRI. Compared with LC3 mice, PLC3 mice developed more severe kidney damage after IRI. Renal tubules were isolated from LC3 mice at baseline for primary culture. OKP cells were transiently transfected with GFP-LC3 plasmid. CRP addition exacerbated lactate dehydrogenase release from both cell types. Immunoblots showed lower LC-3 II/I ratios and higher levels of p62, markers of reduced autophagy flux, in the kidneys of PLC3 mice compared to LC3 mice after IRI, and in primary cultured renal tubules and OKP cells treated with CRP and H2O2 compared to H2O2 alone. Immunohistochemistry showed much fewer LC-3 punctae, and electron microscopy showed fewer autophagosomes in kidneys of PLC3 mice compared to LC3 mice after IRI. Similarly, CRP addition reduced GFP-LC3 punctae induced by H2O2 in primary cultured proximal tubules and in GFP-LC3 plasmid transfected OKP cells. Rapamycin, an autophagy inducer, rescued impaired autophagy and reduced renal injury in vivo. In summary, it was suggested that CRP be more than mere biomarker in AKI, and render the kidney more susceptible to ischemic/oxidative injury, which is associated with down-regulating autophagy flux.
A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)
<p>The dataset used to generate analysis included in the study "A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)"</p>
Deferiprone for the Prevention of Contrast-Induced Acute Kidney Injury
ClinicalTrials.gov study NCT01146925. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Endothelial Glycocalyx Damage in Acute Kidney Injury
ClinicalTrials.gov study NCT05471583. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of the Incidence and Prognosis of Intrahospital Acute Kidney Injury
ClinicalTrials.gov study NCT06697730. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Acute Kidney Injury in Patients With CoVID-19
ClinicalTrials.gov study NCT04872764. IPD Sharing: NO. Countries: 1. Publications: 0.
A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving First Cycle of Cisplatin Chemotherapy for Head and Neck Cancers
ClinicalTrials.gov study NCT01936376. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Serum and Urine Metabolome Studies in Patients With Acute Kidney Injury After Cardiac Surgery
ClinicalTrials.gov study NCT06245720. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury
ClinicalTrials.gov study NCT02701127. IPD Sharing: NO. Countries: 1. Publications: 0.
Acute Kidney Injury After Elective Total Joint Arthroplasty
ClinicalTrials.gov study NCT05595694. IPD Sharing: NO. Countries: 1. Publications: 0.
Risk Factors of Postoperative Acute Kidney Injury and Mortality Among Hospitalized Patients Undergoing Major Surgery
ClinicalTrials.gov study NCT07136194. IPD Sharing: NO. Countries: 1. Publications: 0.
Indoxyl Sulfate Induces Leukocyte-endothelial Interactions Through Up-regulation of ICAM-1 in Acute Kidney Injury
ClinicalTrials.gov study NCT02061566. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury
ClinicalTrials.gov study NCT05659589. IPD Sharing: NO. Countries: 1. Publications: 0.
Gut Microbiota and Sepsis-associated Acute Kidney Injury
ClinicalTrials.gov study NCT05718804. IPD Sharing: NO. Countries: 1. Publications: 0.
Incidence, Risk Factors, and Risk Model of Acute Kidney Injury in Pediatric Patients Who Undergoing Surgery for Congenital Heart Disease
ClinicalTrials.gov study NCT02081235. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness-Implementation Evaluation of Acute Kidney Injury Decision Support
ClinicalTrials.gov study NCT06840210. IPD Sharing: NO. Countries: 0. Publications: 0.
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
ClinicalTrials.gov study NCT06365827. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury.
ClinicalTrials.gov study NCT04533100. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Aetiology, Management and Outcomes of Acute Kidney Injury in Samoa.
ClinicalTrials.gov study NCT05167292. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.