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Dataset results
441 results for “Amyloidosis”
HGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis
GEO Series GSE35400. Mus musculus. 8 samples. Type: Expression profiling by array.
Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [5xFAD-MITRG Astrocytes 6M]
GEO Series GSE271423. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Data from: Natural history and long-term effects of variant protein reduction in non-V30M ATTR amyloidosis
No abstract
Quantitative MRI assessment of peripheral nerve injury in ATTRv amyloidosis patients
<p>Background and Objectives: Early detection of peripheral nerve damage in patients with hereditary transthyretin amyloidosis (ATTRv) has become essential for the prompt initiation of effective therapies that have been recently approved. In our study, we propose a new variable echo time (vTE) MRI sequence for aiding in the quantitative assessment of nerve damage. The approach allows the detection of signals from short T2 components of the nerve, such as the epineurium, myelin, and possibly pre-fibrillar amyloid material deposition within the nerve.</p> <p>Methods: In this cohort study, twenty patients with clinically confirmed ATTRv polyneuropathy (PNP) and twenty-one healthy controls (HC) underwent 3T MRI. vTE was performed on the right thigh with a 6 cm longitudinal coverage of the sciatic nerve between the gluteal region and the popliteal fossa. From the vTE acquisition, cross-sectional area (CSA) of epineurium and fascicular regions were calculated manually and the corresponding pseudoT2* (pT2*), a parameter related to the intrinsic T2 relaxation time of a given tissue, was extrapolated from the two acquired echoes of the vTE.</p> <p>Results: Significantly higher CSA, fascicular area, and pT2* were found in the ATTRv group compared to healthy controls. pT2* also correlated with previously validated clinical outcome measures (i.e., Polyneuropathy Disability Scoring System, Neuropathy Impairment Score (NIS), and NIS items related to lower limbs), and with nerve conduction parameters, demonstrating the ability to discriminate ATTRv patients with different degrees of PNP from HC.</p> <p>Conclusion: In conclusion, the vTE sequence provides novel and reliable imaging markers capable of detecting early nerve microstructural changes that relate to disease onset and severity.</p>
Study of Eque-cel CAR-T Therapy in Newly Diagnosed Severe AL Amyloidosis
ClinicalTrials.gov study NCT07055724. IPD Sharing: NO. Countries: 0. Publications: 0.
Observational Epidemiological Study of Patients Suffering From Systemic Amyloidosis
ClinicalTrials.gov study NCT06866912. IPD Sharing: NO. Countries: 1. Publications: 0.
Diagnosis of Cardiac Amyloidosis With 99mTc-PYP; Comparison Between Planar Imaging, SPECT/CT and Cardiac-dedicated CZT Camera
ClinicalTrials.gov study NCT04146415. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Risk-adapted Therapy for Primary Systemic (AL) Amyloidosis
ClinicalTrials.gov study NCT01527032. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Microneedling Alone vs Microneedling With PRP in the Treatment of Macular Amyloidosis; a Split Face Comparative Study
ClinicalTrials.gov study NCT07360860. IPD Sharing: NO. Countries: 0. Publications: 0.
An Open-Label Study of the Safety of an Anti-CD38 Antibody Drug Conjugate (STI-6129) in Patients With AL Amyloidosis
ClinicalTrials.gov study NCT05692908. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Probiotic Supplementation Reduces Gastrointestinal Symptoms During the Therapy and Improves Therapeutic Response in AL Amyloidosis
ClinicalTrials.gov study NCT05776940. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With t(11;14) Primary AL Amyloidosis
ClinicalTrials.gov study NCT07335887. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study Investigating Coagadex in the Treatment AFXD Associated With AL Amyloidosis
ClinicalTrials.gov study NCT06963216. IPD Sharing: NO. Countries: 1. Publications: 0.
Characteristics of Patients With Amyloidosis & Heart Failure Being Evaluated for a Heart Transplant
ClinicalTrials.gov study NCT00456040. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Better Classification of Respiratory Amyloidosis
ClinicalTrials.gov study NCT05862961. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Validation of Different Diagnostic Modalities in the Detection of Cardiac Amyloidosis Among Patients With "Red Flags"
ClinicalTrials.gov study NCT06175858. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expanded Access Protocol to Provide Patisiran to Patients With Transthyretin-mediated Amyloidosis With Cardiomyopathy
ClinicalTrials.gov study NCT05505838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Stapokibart for Primary Cutaneous Amyloidosis
ClinicalTrials.gov study NCT07143864. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Bortezomib for Immunoglobulin Light Chain(AL) Amyloidosis
ClinicalTrials.gov study NCT02485613. IPD Sharing: Not stated. Countries: 0. Publications: 0.
BCMA/CD3 BiTE for RRAL or NDAL Amyloidosis With Insufficient Depth of Hematologic Response After Induction Therapy
ClinicalTrials.gov study NCT06769555. IPD Sharing: NO. Countries: 0. Publications: 0.
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