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1,985 results for “Antigen”
Data from: Reprogramming the antigen specificity of B cells using genome-editing technologies
We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair strategy, to replace the heavy chain (HC) variable region in B cell lines with that from an HIV broadly neutralizing antibody, PG9. Our strategy is designed to function in cells that have undergone VDJ recombination using any combination of variable (V), diversity (D) and joining (J) genes. The modified locus expresses PG9 HC which pairs with native light chains resulting in the cell surface expression of HIV specific B cell receptors (BCRs). Endogenous activation-induced cytidine deaminase (AID) in engineered cells allowed for Ig class switching and generated BCR variants with improved anti-HIV neutralizing activity. Thus, BCRs engineered in this way retain the genetic flexibility normally required for affinity maturation during adaptive immune responses. Peripheral blood derived primary B cells from three different donors were edited using this strategy. Engineered cells could bind the PG9 epitope by FACS and sequenced mRNA from these cells showed PG9 HC expressed as several different isotypes after culture with CD40 ligand and IL-4.
Source data of main figures of the effect of splicing inhibition on antigen presentation
<p>The success of cancer immunotherapy relies on the induction of an immunoprotective response targeting tumor antigens (TAs) presented on MHC-I molecules. We demonstrated that the splicing inhibitor isoginkgetin and its water-soluble and non-toxic derivative IP2 act at the production stage of the Pioneer Translation Products (PTPs). We showed that IP2 increases PTP-derived antigen presentation in cancer cells <i>in vitro </i>and impairs tumor growth <i>in vivo</i>. IP2 action is long-lasting and dependent on the CD8<sup>+</sup> T cell response against TAs. We observed that the antigen repertoire displayed on MHC-I molecules at the surface of MCA205 fibrosarcoma is modified upon treatment with IP2. In particular, IP2 enhances the presentation of an exon-derived epitope from the tumor suppressor nischarin. The combination of IP2 with a peptide vaccine targeting the nischarin-derived epitope showed a synergistic antitumor effect. These findings identify the spliceosome as a druggable target for the development of epitope-based immunotherapies.<b> </b></p>
Antigen discrimination by T cells relies on size-constrained microvillar contacts
<p>Raw imaging data for publication with the same name. </p>
Search strategies for overview of multiplex antigen near-patient testing for acute respiratory infections
<p>The dataset includes the complete, reproducible search strategies for all literature databases searched during this project. The search strategies were designed to answer the following research questions: </p> <ul> <li>What is known about the effectiveness of multiplex antigen NPTs to correctly classify a person as having SARS-CoV-2 and influenza and or RSV or not in residential and primary care settings?</li> <li>What are the advantages and disadvantages of using multiplex antigen NPTs for the diagnosis of SARS-CoV-2 and influenza and or RSV in residential and primary care settings (for example, turnaround time, appropriateness of patient treatment, or ability to subtype viruses)?</li> <li>What is known about the feasibility (cost and resource implications) of implementing multiplex antigen NPTs for the diagnosis of SARS-CoV-2 and influenza and or RSV in residential and primary care settings?</li> </ul>
Gallium-68 Prostate Specific Membrane Antigen PET in Diagnosing Patients With Thyroid Cancer
ClinicalTrials.gov study NCT03463889. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of a Multi-Antigen Therapeutic Vaccine in Patients With Metastatic Melanoma
ClinicalTrials.gov study NCT00613509. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study of Androgen Deprivation With Leuprolide, +/- Docetaxel for Clinically Asymptomatic Prostate Cancer Participants With a Rising Prostate Specific Antigen (PSA)
ClinicalTrials.gov study NCT00514917. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Different Suppliers
ClinicalTrials.gov study NCT01412281. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Vopratelimab (JTX-2011) Alone and in Combination With Anti-Programmed Cell Death Protein 1 (PD-1) or Anti-Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) in Subjects With Advanced and/or Refractory Solid Tu
ClinicalTrials.gov study NCT04319224. IPD Sharing: NO. Countries: 1. Publications: 0.
A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT05242965. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of GSK Biologicals' Reduced Antigen Diphtheria and Tetanus Toxoids and Acellular Pertussis- Inactivated Poliovirus Vaccine, to BoostrixTM and Inactivated Poliovirus Vaccine Administered Sep
ClinicalTrials.gov study NCT01277705. IPD Sharing: YES. Countries: 0. Publications: 3.
Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression
ClinicalTrials.gov study NCT05683964. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study to Assess Immunity to Specific Microbial Antigens in Healthy Smokers and Non-smokers and in Subjects With Stable COPD
ClinicalTrials.gov study NCT01516437. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Samarium Sm 153 Lexidronam Pentasodium and 3-Dimensional Conformal Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Rising Prostate-Specific Antigen Levels After Ra
ClinicalTrials.gov study NCT00551525. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Utilizing BIOZEK COVID-19 Antigen Rapid Test
ClinicalTrials.gov study NCT04926779. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety, False-Positive Reactions and Sensitizing Properties of Leishmania Tropica Skin Test Antigen
ClinicalTrials.gov study NCT00633009. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Leprosy Skin Test Antigens Phase 1
ClinicalTrials.gov study NCT01920750. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effects of Finasteride on Serum Prostate-Specific Antigen (0906-111)
ClinicalTrials.gov study NCT00396175. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Complement-activating Anti-human Leucocyte Antigen Donor Specific Antibodies in Solid Organ Transplantation
ClinicalTrials.gov study NCT03438058. IPD Sharing: NO. Countries: 0. Publications: 1.
Evaluation of the INDICAID™ COVID-19 Rapid Antigen Test
ClinicalTrials.gov study NCT04904510. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.