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Dataset results
864 results for “Brain function”
Identification of a link between exercise and brain function in humans through mapping of skeletal muscle enhancers [ChIP-Seq]
GEO Series GSE144132. Homo sapiens. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Functional recovery following traumatic brain injury in rats is enhanced by bovine thymus nuclear extract supplementation
GEO Series GSE240927. Rattus norvegicus. 25 samples. Type: Expression profiling by high throughput sequencing.
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
GEO Series GSE145386. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain
GEO Series GSE37997. Macaca mulatta. 8 samples. Type: Expression profiling by array.
Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function [cKO RNA-seq]
GEO Series GSE222664. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Sequencing During Mouse Brain Development Identifies Long Non-Coding RNAs Functionally Involved in Neurogenic Commitment
GEO Series GSE51606. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq of a suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality
GEO Series GSE112846. Mus musculus. 4776 samples. Type: Expression profiling by high throughput sequencing.
Extensive sex differences in depression-linked variants functionally assayed in mouse brain [P0&P10]
GEO Series GSE186347. Mus musculus; Adeno-associated virus 9. 44 samples. Type: Expression profiling by high throughput sequencing; Other.
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
GEO Series GSE292306. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Brain motor and fear circuits differentially regulate leukocyte distribution and function during acute stress
GEO Series GSE201392. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Embryonic exposure to 10 µg/L lead results in male-specific expression changes in genes associated with nervous system development and function and Alzheimer’s disease in aged adult zebrafish brain
GEO Series GSE74038. Danio rerio. 7 samples. Type: Expression profiling by array.
Disrupted functional neworks in autism underlie early brain maldevelopment and provide accurate classification
GEO Series GSE42133. Homo sapiens. 147 samples. Type: Expression profiling by array.
Data from: Integrated analysis and visualization of group differences in structural and functional brain connectivity: applications in typical ageing and schizophrenia
Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple metrics are presented. On the global level, "bi-modal comparison plots" show the distribution of uni- and bi-modal group differences and the relationship between structure and function. Differences between brain lobes are visualized using "worm plots". Group differences in connections are examined with an existing visualization, the "connectogram". These visualizations were evaluated in two proof-of-concept studies: (1) middle-aged versus elderly subjects; and (2) patients with schizophrenia versus controls. Each included two measures derived from diffusion weighted images and two from functional magnetic resonance images. The structural measures were minimum cost path between two anatomical regions according to the "Statistical Analysis of Minimum cost path based Structural Connectivity" method and the average fractional anisotropy along the fiber. The functional measures were Pearson's correlation and partial correlation of mean regional time series. The relationship between structure and function was similar in both studies. Uni-modal group differences varied greatly between connectivity types. Group differences were identified in both studies globally, within brain lobes and between regions. In the aging study, minimum cost path was highly effective in identifying group differences on all levels; fractional anisotropy and mean correlation showed smaller differences on the brain lobe and regional levels. In the schizophrenia study, minimum cost path and fractional anisotropy showed differences on the global level and within brain lobes; mean correlation showed small differences on the lobe level. Only fractional anisotropy and mean correlation showed regional differences. The presented visualizations were helpful in comparing and evaluating connectivity measures on multiple levels in both studies.
Data from: Effects of a 60 Hz magnetic field exposure up to 3000 µT on human brain activation as measured by functional magnetic resonance imaging
Several aspects of the human nervous system and associated motor and cognitive processes have been reported to be modulated by extremely low-frequency (ELF, < 300 Hz) time-varying Magnetic Fields (MF). Due do their worldwide prevalence; power-line frequencies (60 Hz in North America) are of particular interest. Despite intense research efforts over the last few decades, the potential effects of 60 Hz MF still need to be elucidated, and the underlying mechanisms to be understood. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to characterize potential changes in functional brain activation following human exposure to a 60 Hz MF through motor and cognitive tasks. First, pilot results acquired in a first set of subjects (N=9) were used to demonstrate the technical feasibility of using fMRI to detect subtle changes in functional brain activation with 60 Hz MF exposure at 1800 μT. Second, a full study involving a larger cohort of subjects tested brain activation during 1) a finger tapping task (N=20), and 2) a mental rotation task (N=21); before and after a one-hour, 60 Hz, 3000 μT MF exposure. The results indicate significant changes in task-induced functional brain activation as a consequence of MF exposure. However, no impact on task performance was found. These results illustrate the potential of using fMRI to identify MF-induced changes in functional brain activation, suggesting that a one-hour 60 Hz, 3000 μT MF exposure can modulate activity in specific brain regions after the end of the exposure period (i.e., residual effects). We discuss the possibility that MF exposure at 60 Hz, 3000 μT may be capable of modulating cortical excitability via a modulation of synaptic plasticity processes.
Personalized Large-scale Functional Networks in the Adolescent Brain Cognitive Development (ABCD) Children
<ul><li>Data for our paper "<strong>Personalized Large-scale Functional Networks in ABCD Children: Linking Functional Network Topography with Socioeconomic Status</strong>".</li><li>This dataset contains personalized functional networks for <strong>3,921</strong> participants (age 9- and 10-year-olds) who had more than 20 min of high-quality (mean motion < 0.2mm) resting-state fMRI data from the Adolescent Brain Cognitive Development (<strong>ABCD</strong>) Study.</li><li>Using regularized non-negative matrix factorization (<strong>NMF</strong>) and preprocessed resting-state fMRI data from the ABCD-BIDS Community Collection (<strong>https://github.com/ABCD-STUDY/nda-abcd-collection-3165</strong>, NDA Collection 3165), we parcellated the cortex (<strong>fsLR_32k space</strong>) into 17 functional networks for each ABCD participant.</li><li>We provided two kinds of atlas data: discrete network parcellation (<strong>IndivAtlasLabel</strong>) and probabilistic network parcellation (<strong>IndivAtlasLoading</strong>). For discrete network parcellation, each value in the dscalar indicates which network this vertex belongs to; for probabilistic network parcellation, each value indicates the probability that this vertex belongs to each network (<strong>17 in total</strong>). We also provided group atlas label and atlas loading for comparison.</li><li>For dscalars contain individual atlas loading, we separated participants into 10 parts, each has nearly 400 individuals for easily uploading and downloading.</li><li>Each value corresponds with the following key for discrete network parcellation: 1=FP1, 2=AU, 3=VS1, 4=DM1, 5=DA, 6=DM2, 7=DA2, 8=DM3, 9=VS2, 10=SM1, 11=TMP, 12=LB 13=VA1, 14=FP2, 15=SM2, 16=SM3, 17=DA3 (VS: visual; AU: auditory; SM: somatomotor; VA: ventral attention; DA: dorsal attention; FP: fronto-parietal; DM: default mode; TM: temporo-parietal; LB: limbic).</li><li>For each participant, we provide his or her subject-key in the ABCD Study. Other related information can be found at <strong>https://wiki.abcdstudy.org</strong>.</li><li>Relevant analysis scripts can be found in <strong>https://github.com/CuiLabCIBR/SingleFuncParcel_ABCD</strong>.</li></ul>
Micropatterned neurovascular interface to mimic the blood-brain barrier neurophysiology and micromechanical function
<p><strong>Supplementary Materials: </strong>A list of additional supporting information with the immunostaining of tight junction (zona occludens-1, glucose transporter); Quantitative impedance measurement; Analysis of Ca sparks parameters and spatiotemporal density analysis of calcium signaling in endothelial cells are supplied.</p>
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
<p>Raw data for Figure 2. Readme file with info regarding the data. Zip file is about 40 GB as contains all raw images used for quantification presented in figure 2 and in supplementary 7</p>
Effects of a GLP-1 Receptor Agonist on Functional Activation and Connectivity of the Brain
ClinicalTrials.gov study NCT02745470. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Contrasting the Brain Effects of Risperidone and Invega With Functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) Scanning
ClinicalTrials.gov study NCT00937261. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
ClinicalTrials.gov study NCT05577598. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.