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410
datasets available to search
ShareScore release 0.9.0
Dataset results
410 results for “Mitochondrial gene”
Genome-wide analysis of murine white adipose tissue gene expression in response to an overexpression of mitochondrial ferritin
GEO Series GSE125900. Mus musculus. 4 samples. Type: Expression profiling by array.
Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage.
GEO Series GSE40585. Homo sapiens. 54 samples. Type: Expression profiling by array.
Ago2 protects against diabetic cardiomyopathy via activating mitochondrial gene translation
GEO Series GSE224684. Mus musculus. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Characterization of mitochondrial alterations in Aicardi-Goutières patients mutated in RNASEH2A and RNASEH2B Genes
<p>The database includes the raw data of the article “Characterization of mitochondrial alterations in Aicardi-Goutières patients mutated in RNASEH2A and RNASEH2B genes”. Aim of the work was to investigate the role of mitochondria in AGS, both from a functional and a morphological point of view in lymphoblastoid cell lines (LCLs) derived from AGS patients mutated in the RNASEH2A and RNASEH2B genes, to ultimately establish the role of mitochondria in the pathogenesis of AGS. The database contains data obtained by means the following evaluations: i) flow cytometry analysis for the evaluation of the intermembrane mitochondrial potential (TMRE-Mitotracker) and for the quantification of produced ROS; ii) Seahorse Analysis for the evaluation of metabolic and energetic status of mutated LCLs; iii) RT-qPCR to determine the expression level of two glycolytic genes (PDK1 and LDHb) and quantify the mtDNA release into the cytoplasm; iiii) Western Blot analysis to quantify Oxphos system complexes protein level.</p> <p>Both mutant LCLs showed morphological and structural changes in mitochondria when compared to healthy controls, while RNASEH2A LCLs had the most loss of physiological membrane potential. Both mutant LCLs produced more ROS, but RNASEH2B LCLs produced substantially more. RNASEH2B LCLs had a considerably higher amount of cytoplasmic mtDNA. Mitochondrial damage was further confirmed by metabolic changes in both mutant cell lines. In particular RNASEH2A mutated LCLs showed higher ATP production rate and proton leak. These data were also confirmed by the expression level of two glycolytic genes that resulted enhanced in the RNASEH2A mutated cell line. Oxphos system complexes protein level did not show any significant differences. Our findings reveal for the first time the presence of mitochondrial abnormalities in AGS patients' LCLs, implying that these organelles play a critical role in AGS etiology.</p>
Transfer of mitochondrial DNA into the nuclear genome during gene editing [PEM-Seq MT stress]
GEO Series GSE261864. Homo sapiens. 9 samples. Type: Other.
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems: TP53inp2 (DOR) RNAi knock-downs
GEO Series GSE39318. Mus musculus. 8 samples. Type: Expression profiling by array.
Anterograde Regulation of Nuclear-encoded Mitochondrial Genes and FGF21 Signaling by Hepatic Histone Demethylase LSD1 [RNA-seq]
GEO Series GSE161286. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transfer of mitochondrial DNA into the nuclear genome during gene editing [mitoTALEN_ND4 PEM-seq]
GEO Series GSE248510. Homo sapiens. 6 samples. Type: Other.
Transfer of mitochondrial DNA into the nuclear genome during gene editing [ND5.3 PEM-seq]
GEO Series GSE248511. Homo sapiens. 6 samples. Type: Other.
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in platinum-resistant ovarian cancer by suppressing mitochondrial function and expression of genes related to inflammation and DNA repair.
GEO Series GSE251890. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.