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460
datasets available to search
ShareScore release 0.9.0
Dataset results
460 results for “underlying mechanism”
Molecular mechanisms underlying reprogramming of mouse fibroblasts into pluripotent stem cells
GEO Series GSE21067. Mus musculus. 9 samples. Type: Expression profiling by array.
mRNA-sequencing uncovered the underlying mechanisms of xylazine related liver injury
GEO Series GSE271044. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
Analysis of rabbiteye blueberry metabolomes and transcriptomes reveals mechanisms underlying potassium-induced anthocyanin production
GEO Series GSE277541. Vaccinium virgatum. 9 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms underlying the modulation of T-cell proliferation and cytotoxicity by immobilized CCL21 and ICAM1
GEO Series GSE254335. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome and DNA Methylome Analyses Reveal Underlying Mechanisms for the Racial Disparity in Uterine Fibroids
GEO Series GSE207350. Homo sapiens. 108 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array.
Integrative Transcriptomics and Proteomics Profiling of Arabidopsis thaliana Elucidates Novel Mechanisms Underlying Spaceflight Adaptation
Spaceflight presents a unique environment with complex stressors, including microgravity and radiation, that can influence plant physiology at molecular levels. Combining transcriptomics and proteomics approaches, this research gives insights into the coordination of transcriptome and proteome in Arabidopsis’ molecular and physiological responses to Spaceflight environmental stress. Arabidopsis seedlings were germinated and grown in microgravity (µg) aboard the International Space Station (ISS) in NASA Biological Research in Canisters -Light Emitting Diode (BRIC LED) hardware, with the ground control established on Earth. At 10 days old, seedlings were frozen in RNA-later and returned to Earth. RNA-seq transcriptomics and TMT-labeled LC-MS/MS proteomic analysis of cellular fractionates from the plant tissues suggest the alteration of the photosynthetic machinery (PSII and PSI) in spaceflight, with the plant shifting photosystem core-regulatory proteins in an organ-specific manner to adapt to the microgravity environment. An overview of the ribosome, spliceosome, and proteasome activities in spaceflight revealed a significant abundance of transcripts and proteins involved in protease binding, nuclease activities, and mRNA binding in spaceflight, while those involved in tRNA binding, exoribonuclease activity, and RNA helicase activity were less abundant in spaceflight. CELLULOSE SYNTHASES (CESA1, CESA3, CESA5, CESA7) and CELLULOSE-LIKE PROTEINS (CSLE1, CSLG3), involved in cellulose deposition and TUBULIN COFACTOR B (TFCB) had reduced abundance in spaceflight. This contrasts with the increased expression of UDP-ARABINOPYRANOSE MUTASEs, involved in the biosynthesis of cell wall non-cellulosic polysaccharides, in spaceflight. Both transcripts and proteome suggested an altered polar auxin redistribution, lipid, and ionic intracellular transportation in spaceflight. Analyses also suggest an increased metabolic energy requirement for plants in Space than on Earth, hence, the activation of several shunt metabolic pathways. This study provides novel insights, based on integrated RNA and protein data, on how plants adapt to the spaceflight environment and it is a step further at achieving sustainable crop production in Space.
Comparative transcriptome analysis unveiling molecular mechanisms underlying low temperature resistance in the white mangrove Laguncularia racemosa
GEO Series GSE208631. Laguncularia racemosa. 22 samples. Type: Expression profiling by high throughput sequencing.
Kinetical scRNAseq Analysis Reveals Immune Mechanisms Underlying Hindered Lung Recovery following Influenza Virus Infection in Aged Hosts
GEO Series GSE271578. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-cell Transcriptomes and Follicular Fluid Proteomics of Ovine Atretic Follicles Reveal the Underlying Mechanisms of Oocyte Degeneration
GEO Series GSE268651. Ovis aries. 6 samples. Type: Expression profiling by high throughput sequencing.
The underlying mechanism by which ZCCHC7 exerted carcinogenesis and its potential targets in CRC
GEO Series GSE234581. Homo sapiens. 4 samples. Type: Other.
Insights into the mechanism underlying the therapeutic effects of raspberry ketone on human colorectal carcinoma cells revealed by RNA sequencing and bioinformatics analysis
GEO Series GSE122587. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of molecular mechanisms underlying phenotypic variation in Phaseolus vulgaris mutant nts
GEO Series GSE227577. Phaseolus vulgaris. 6 samples. Type: Expression profiling by high throughput sequencing.
Widespread chromatin activation underlies pathogenic mechanisms in multiple myeloma
GEO Series GSE122638. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Disrupted Brain Progenitor Development and Signaling as a New Mechanism Underlying Microcephaly
GEO Series GSE279902. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Mechanisms Underlying Morphological and Functional Changes of Cilia in Fibroblasts Derived from Patients Bearing ARL3T31A and ARL3T31A/C118F Mutations
GEO Series GSE275978. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Research on the mechanisms underlying Arctium lappa L. polysaccharide-induced proliferation of epidermal stem cells
GEO Series GSE314507. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Studies on the mechanisms underlying human epidermal stem cell differentiation by epigallocatechin gallate
GEO Series GSE301803. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Studies on the mechanisms underlying Angiopoietin-like 4-induced epidermal stem cell proliferation
GEO Series GSE282348. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis to find molecular mechanisms underlying the role of miR-342-5p in HER2 breast cancer
GEO Series GSE108324. Homo sapiens. 24 samples. Type: Expression profiling by array.
In-depth transcriptomic analyses investigating molecular mechanisms underlying the osteogenic differentiation of human renal interstitial fibroblasts.
GEO Series GSE203110. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.