Find research datasets worth reusing

Estimation of Pulmonary Vascular Resistance by Contrast Echocardiography

ClinicalTrials.gov study NCT02028299. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

ClinicalTrials.gov study NCT04905173. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Comparison of Traditional and Echocardiography Guided Fluid Management During Cytoreductive Surgery With HIPEC

ClinicalTrials.gov study NCT01225757. IPD Sharing: Not stated. Countries: 0. Publications: 0.

D-Dimer-based Indication for Transesophageal Echocardiography to Exclude Left Atrial Thrombus Before Cardioversion of Non-anticoagulated Atrial Fibrillation: A Multicenter Belgian Study

ClinicalTrials.gov study NCT04784039. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

ClinicalTrials.gov study NCT04228510. IPD Sharing: NO. Countries: 0. Publications: 0.

Focused Assessed Echocardiography to Predict Fluid Responsiveness

ClinicalTrials.gov study NCT03044405. IPD Sharing: NO. Countries: 0. Publications: 0.

A Hemodynamically Oriented Echocardiography-Based Strategy in the Treatment of Congestive Heart Failure

ClinicalTrials.gov study NCT00280254. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery

ClinicalTrials.gov study NCT01310608. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Contribution of Echocardiography to Prognostic Evaluation of Pulmonary Arterial Hypertension

ClinicalTrials.gov study NCT02885155. IPD Sharing: NO. Countries: 0. Publications: 0.

3D Echocardiography Managing Infantile Pompe's Disease

ClinicalTrials.gov study NCT00277979. IPD Sharing: Not stated. Countries: 0. Publications: 0.

The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia

ClinicalTrials.gov study NCT05082272. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Quantitative Assessment of Hypertrophic Obstructive Cardiomyopathy With Intraoperative Three-dimensional Transesophageal Echocardiography Under Provocative Dobutamine Stress Test

ClinicalTrials.gov study NCT05025644. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Trial Comparing Routine Intraoperative Transesophageal Echocardiography During Radical Cystectomy to Standard of Care

ClinicalTrials.gov study NCT03058250. IPD Sharing: NO. Countries: 0. Publications: 0.

Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)

ClinicalTrials.gov study NCT00286559. IPD Sharing: Not stated. Countries: 0. Publications: 0.

Artificial Intelligence for Reconstruction of Echocardiography Studies

ClinicalTrials.gov study NCT07093918. IPD Sharing: Not stated. Countries: 0. Publications: 0.

restrictedOct 2020View details →

zenodo16/100

Dataset related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"

This record contains raw data related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling" Abstract: The “ideal” management of asymptomatic severe mitral regurgitation (MR) in valve prolapse (MVP) is still debated. The aims of this study were to identify pre‐operatory parameters predictive of residual MR and of early and long‐term favorable remodeling after MVP repair. We included 295 patients who underwent MV repair for MVP with pre‐operatory two‐ and threedimensional transthoracic echocardiography (2DTTE and 3DTTE) and 6‐months (6M) and 3‐years (3Y) follow‐up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures as simple or complex. Pre‐operative echo parameters were compared to post‐operative values at 6M and 3Y. Patients were divided into Group 1 (6M‐MR < 2) and Group 2 (6M‐MR ≥ 2), and predictors of MR  2 were investigated. MVP was simple in 178/295 pts, and 94% underwent simple procedures, while in only 42/117 (36%) of complex MVP a simple procedure was performed. A significant relation among prolapse anatomy, surgical procedures and residual MR was found. Postoperative MR ≥ 2 was present in 9.8%: complex MVP undergoing complex procedures had twice the percentage of MR ≥ 2 vs. simple MVP and simple procedures. MVP complexity resulted independent predictor of 6M‐MR ≥ 2. Favorable cardiac remodeling, initially found in all cases, was maintained only in MR < 2 at 3Y. Pre‐operative 3DTTE MVP morphology identifies pts undergoing simple or complex procedures predicting MR recurrence and favorable cardiac remodeling.

restrictedFeb 2020View details →

CMR for Identifying the Substrate of Ventricular Arrhythmia in Patients with Q1 Normal Echocardiography

OBJECTIVES This study sought to determine whether cardiac magnetic resonance (CMR) may identify structural heart disease (SHD) in patients with ventricular arrhythmia who had echocardiography ruled out pathological findings. BACKGROUND Approximately one-half of sudden cardiac deaths are attributable to malignant VA. Echocardiography is commonly used to identify SHD that is the most frequent substrate of VA. Q6 METHODS A single-center prospective study was conducted in consecutive patients with significant VA, categorized as >1,000 but <10,000 ventricular ectopic beats [VEB]s/24 h; $10,000 VEBs/24 h; nonsustained ventricular tachycardia, sustained ventricular tachycardia (SVT), or a history of resuscitated cardiac arrest, and no pathological findings at echocardiography, requiring a clinically indicated CMR. Primary endpoint was CMR detection of SHD. Secondary endpoints were a composite of CMR detection of SHD and abnormal findings not specific for a definite SHD diagnosis. RESULTS A total of 946 patients were enrolled (mean 41 16 years of age; 64% men). CMR studies were used to diagnose SHD in 241 patients (25.5%) and abnormal findings not specific for a definite SHD diagnosis in 187 patients (19.7%). Myocarditis (n ¼ 91) was the more frequent disease, followed by arrhythmogenic cardiomyopathy (n ¼ 55), dilated cardiomyopathy (n ¼ 39), ischemic heart disease (n ¼ 22), hypertrophic cardiomyopathy (n ¼ 13), congenital cardiac disease (n ¼ 10), left ventricle noncompaction (n ¼ 5), and pericarditis (n ¼ 5). The strongest univariate and multivariate predictors of SHD on CMR images were chest pain (odds ratios [OR]: 2.52 and 2.38, respectively) and SVT (ORs: 2.67 and 2.23, respectively). CONCLUSIONS SHD was able to be identified on CMR imaging in a sizable number of patients with significant VA and completely normal echocardiography. Chest pain and SVT were the strongest predictors of positive CMR imaging results.

restrictedJan 2021View details →

Dataset related to the article 'Diagnostic Accuracy of Transillumination in Mitral Valve Prolapse: Side-by-Side Comparison of Standard Transthoracic Three-Dimensional Echocardiography against Surgical Findings'

This record contains raw data related to the article 'Diagnostic Accuracy of Transillumination in Mitral Valve Prolapse: Side-by-Side Comparison of Standard Transthoracic Three-Dimensional Echocardiography against Surgical Findings' In patients with mitral valve (MV) prolapse (MVP) eligible for surgery, three-dimensional echocardiography (3DE) is routinely used for pre-operative assessment. Despite the worldwide use of transesophageal echocardiography in this context, transthoracic echocardiography (TTE) allows accurate noninvasive evaluation of MV anatomy and pathology in patients with good acoustic windows. Transillumination (TI) is a new 3D tool that improves the visualization of cardiac structures due to shadow effects achieved by the use of a virtual light source. We aimed to compare the diagnostic accuracy of TTE TI side-by-side with standard 3DE (s3DE) display in patients undergoing surgery for MVP, using surgical valve inspection as a reference standard. We prospectively studied 59 patients with good acoustic windows on TTE, undergoing surgery for MVP. The study was approved by the institutional review board with a written informed consent. 3D MV analysis, including evaluation of scallops, chordal rupture and cleft was performed using s3DE and TI. Data were acquired by two experienced operators using zoomed acquisition mode over 4 to 6 cardiac cycles and processed by adjusting gain, brightness and smoothing. For TI images, the virtual light source was set in the left ventricle to enhance MV visualization. At the end of each TTE study, a first reader analyzed post-processed s3DE images and, one week later, the TI images. Surgical findings of MV anatomy were collected and agreement was expressed using Cohen’s concordance coefficient kappa, sensitivity, specificity, negative and positive predictive value (NPV, PPV) and overall accuracy. A second reader, blinded to all prior measurements, repeated TI analysis to assess reproducibility using intraclass correlation coefficients (ICC).  No differences were noted in etiological diagnosis (Myxomatous vs Fibroelastic Deficiency) between the two 3DE techniques and surgery. Based on s3DE, 53 patients (90%) were diagnosed with P2 flail secondary to chordal rupture (N=51, 86%) or elongation (N=2, 14%). A cleft was diagnosed in 10 cases (17%), mostly located in the posterior leaflet. Based on TI, 53 patients (88%) were diagnosed with P2 flail secondary to chordal rupture (N=48, 81%) or elongation (N=5, 19%). In 9 patients (15%) a cleft was found, mainly located in the posterior leaflet. The reproducibility of TI was good for prolapse detection (ICC=0.78) and chordal rupture localization (ICC= 0.73) and fair for cleft identification (ICC= 0.66). Overall, compared to the surgical reference, TI was significantly more accurate than s3DE for the identification of prolapse (94% vs 89%), chordal rupture (98% vs 92%) and cleft localization (87% vs 54%). Specifically, s3DE correctly detected the flail in the majority of patients (N=57, 97%); in 20 patients (34%), at least one scallop was erroneously diagnosed as prolapsing, while in 4 patients (7%), a second prolapsing scallop was missed by s3DE. In 2 cases (3%) the real flail was missed. Agreement between s3DE and surgery in prolapse identification was poor (kappa=0.30).  By TI, the flail was correctly diagnosed in 57 cases (97%), while in 7 patients (12%) there was an over-diagnosis and in 4 cases (7%) an under-diagnosis. In 1 patient (2%), the flail was missed by TI. The agreement between TI and surgery in prolapse detection was considerably better (kappa=0.60). A significant difference (p<0.05) was found between s3DE and TI in sensitivity (87% vs 91%), specificity (92% vs 97%), PPV (75% vs 87%) and NPV (96% vs 98%) in scallop’s prolapse identification. Chordal rupture was diagnosed in 51 patients (86%) by s3DE, compared to 45 (76%) cases confirmed by surgery. Among these 45 patients, s3DE correctly identified rupture position in 41 (91%). The agreement between s3DE and surgery was moderate (kappa=0.43). In contrast, TI identified chordal rupture in 48 cases (81%); among 45 patients confirmed by surgery TI detected the correct rupture position in 44 (98%), resulting in a very good agreement (kappa=0.86). Compared to s3DE, TI showed a significant difference (p<0.05) in sensitivity (89% vs 98%), specificity (95% vs 99%), PPV (74% vs 94%) and NPV (96% vs 99%) in chordal rupture recognition. The agreement with surgery in terms of localization of cleft by s3DE was poor (k=0.17). Surgical valve inspection reported 8 cases (14%) with MV cleft (2 cleft of the anterior leaflet and 6 indentations of the posterior leaflet), only one was correctly diagnosed by s3DE, mainly due to signal drop-out. Concordance between TI and surgery in cleft localization was good (kappa=0.67); TI correctly diagnosed 6 out of 8 clefts. For cleft identification, sensitivity (13% vs 75%), specificity (96% vs 99%), PPV (10% vs 67%), and NPV (97% vs 99%) were significantly better (p<0.05) for TI compared to s3DE. Based on our results, in patients undergoing surgery for MVP, TI has the potential to improve the diagnostic accuracy of TTE in anatomical analysis of the MV compared to s3DE, and may thus contribute towards improved personalized presurgical planning.

restrictedSep 2021View details →

Dataset from: "Prognostic Value of Dynamic Changes in Pulmonary Congestion During Exercise Stress Echocardiography in Heart Failure With Preserved Ejection Fraction"

BACKGROUND: Patients with heart failure (HF) with preserved ejection fraction (HFpEF) typically develop dyspnea and pulmonary congestion upon exercise. Lung ultrasound is a simple diagnostic tool, providing semiquantitative assessment of extravascular lung water through B-lines. It has been shown that patients with HFpEF develop B-lines upon submaximal exercise stress echocardiography; however, whether exercise-induced pulmonary congestion carries prognostic implications is unknown. This study aimed at evaluating the prognostic value of B-line assessment during exercise in patients with HFpEF. METHODS: Sixty-one New York Heart Association class I to II patients with HFpEF underwent standard echocardiography, lung ultrasound (28-scanning point method), and BNP (B-type natriuretic peptide) assessment during supine exercise echocardiography (baseline and peak exercise). The primary end point was a composite of cardiovascular death or HF hospitalization at 1 year. RESULTS: B-lines, E/e′, and BNP significantly increased during exercise (P<0.001 for all). By multivariable analysis, both peak (hazard ratio, 1.50 [95% CI, 1.21–1.85], P<0.001), and change (hazard ratio 1.34 [95% CI, 1.12–1.62], P=0.002) B-lines were retained as independent predictors of outcome (hazard ratios per 1 B-line increment), along with BNP and E/e′ ratio. Importantly, adding peak B-line on top of a clinical model significantly improved prognostic accuracy (C-index increase, 0.157 [0.056–0.258], P=0.002) and net reclassification (continuous net reclassification improvement, 0.51 [0.09–0.74], P=0.016), with similar results for B-line change. CONCLUSIONS: Detection of exercise-induced pulmonary congestion by lung ultrasound is an independent predictor of outcome in patients with HFpEF; its use may help refining the routine risk stratification of these patients on top of well-established clinical variables.