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984 results for “Extracellular Vesicles”
Small extracellular vesicles from malignant ascites of patients with advanced ovarian cancer provide insights into the dynamics of the extracellular matrix
<p>Small extracellular vesicles isolated from ascites of advanced ovarian cancer patients and assessed with a combination of imaging, proteomic profiling, and protein expression analyses.</p>
Lipidomic profile of two differently-sized subsets of porcine seminal extracellular vesicles
<p>Raw data (.CDF) from the lipidomic analysis of two differently-sized subsets (small and large) of seminal extracellular vesicles (sEVs) isolated from porcine seminal plasma. The procedure used for sEV isolation combined serial centrifugations, ultrafiltration and size-exclusion chromatography. High performance liquid chromatography-high resolution mass spectrometry was used for lipidomic analysis.</p>
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart
<p>Extracellular vesicles (EVs) mediate intercellular signaling by transferring their cargo to recipient cells, but the functional consequences of signaling are not fully appreciated. Red blood cell (RBC)-derived EVs are abundant in circulation and have been implicated in regulating immune responses. Here, we use a transgenic mouse model for fluorescence-based mapping of RBC-EV recipient cells to assess the role of this intercellular signaling mechanism in heart disease. Using fluorescent-based mapping, we detected an increase in RBC-EV-targeted cardiomyocytes in a murine model of ischemic heart failure. Single cell nuclear RNA sequencing of the heart revealed a complex landscape of cardiac cells targeted by RBC-EVs, with enrichment of genes implicated in cell proliferation and stress signaling pathways compared to non-targeted cells. Correspondingly, cardiomyocytes targeted by RBC-EVs more frequently express cellular markers of DNA synthesis, suggesting the functional significance of EV-mediated signaling. In conclusion, our mouse model for mapping of EV-recipient cells reveals a complex cellular network of RBC-EV mediated intercellular communication in ischemic heart failure and suggests a functional role for this mode of intercellular signaling.</p>
Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles
<p>We conducted an in vivo screen in zebrafish to identify sources of EVs that could induce MG to dedifferentiate and generate proliferating progenitor cells after intravitreal injection into otherwise undamaged zebrafish eyes.</p> <p>Data for this study can be found here: https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-7058</p>
Electron Microscopy Data for Quantification of Extracellular Vesicles
<p>Electron Microscopy Data for Quantification of Extracellular Vesicles</p>
Unraveling the Role of Extracellular Vesicles-driven Senescence in Myeloproliferative Neoplasms
ClinicalTrials.gov study NCT06798805. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Optimization of the Isolation Protocol for Extracellular Vesicles (EVs) From Human Follicular Fluid
ClinicalTrials.gov study NCT06952751. IPD Sharing: NO. Countries: 1. Publications: 0.
Predicting Response to Anti-PD-1/PD-L1 Immunotherapy by Plasma Extracellular Vesicle Analysis
ClinicalTrials.gov study NCT07376512. IPD Sharing: NO. Countries: 1. Publications: 0.
Spectroscopic Profiling of Extracellular Vesicles By Resonant Gold Nanostructures in the Infrared
ClinicalTrials.gov study NCT06266195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Liver Diseases: Extracellular Vesicles as Biomarkers
ClinicalTrials.gov study NCT07185360. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Determination of Baseline Levels for Prostate Cancer-Derived Extracellular Vesicles Following Local Treatment of Prostate Cancer
ClinicalTrials.gov study NCT06326216. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles
ClinicalTrials.gov study NCT05520125. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS
ClinicalTrials.gov study NCT06598202. IPD Sharing: NO. Countries: 1. Publications: 0.
Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
ClinicalTrials.gov study NCT06444646. IPD Sharing: NO. Countries: 1. Publications: 0.
Plasma Extracellular Vesicles in Meningioma Patients
ClinicalTrials.gov study NCT06104930. IPD Sharing: NO. Countries: 1. Publications: 0.
Decoding the Extracellular Vesicles-driven Communication in the Microenvironment of Hairy Cell Leukemia to Improve Patient Care Management
ClinicalTrials.gov study NCT06774677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles
ClinicalTrials.gov study NCT06642402. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
ClinicalTrials.gov study NCT06434207. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized, Controlled, Multicenter Study of Extracellular Vesicles From Human Adipose Tissue Promoting Wound Healing
ClinicalTrials.gov study NCT06253975. IPD Sharing: NO. Countries: 1. Publications: 0.
Extracellular Vesicles as Potential Biomarkers and Therapeutic Target in Gaucher Disease
ClinicalTrials.gov study NCT05843552. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.