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460
datasets available to search
ShareScore release 0.9.0
Dataset results
460 results for “Immunoglobulin A”
Observation Study an Immunogenicity Modified TRC-ID Regimen With CPRV With or Without Rabies Immunoglobulin in Children
ClinicalTrials.gov study NCT02339896. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Post-Poliosyndrome Treated With Intravenous Immunoglobulin (IvIg)
ClinicalTrials.gov study NCT00231439. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Bortezomib for Immunoglobulin Light Chain(AL) Amyloidosis
ClinicalTrials.gov study NCT02485613. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Changes in Specific Immunoglobulin and Blood Basophil Activity During Subcutaneous Immunotherapy in Allergic Rhinitis
ClinicalTrials.gov study NCT01085526. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Treating Donors With Intravenous Immunoglobulin to Reduce Donor-Derived Infections
ClinicalTrials.gov study NCT05799716. IPD Sharing: NO. Countries: 0. Publications: 0.
Serum Immunoglobulin (G) as a Marker of Diabetic Nephropathy
ClinicalTrials.gov study NCT03212755. IPD Sharing: NO. Countries: 0. Publications: 0.
Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels
ClinicalTrials.gov study NCT06704711. IPD Sharing: YES. Countries: 0. Publications: 0.
Ibrutinib With or Without Bortezomib and Dexamethasone in Treating Patients With Relapsed or Refractory Immunoglobulin Light Chain Amyloidosis
ClinicalTrials.gov study NCT03130348. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Efficacy and Safety of Histamine Human Immunoglobulin in the Treatment of Chronic Spontaneous Urticaria (CSU)
ClinicalTrials.gov study NCT06250400. IPD Sharing: NO. Countries: 0. Publications: 0.
Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia
GEO Series GSE225262. Homo sapiens. 10 samples. Type: Other.
Somatic hypermutation patterns in immunoglobulin variable regions are dictated by a motif-specific sequence grammar and motif position
GEO Series GSE283316. Homo sapiens. 108 samples. Type: Other.
Convergent molecular pathways that induce immunoglobulin light-chain recombination
GEO Series GSE10273. Mus musculus. 9 samples. Type: Expression profiling by array.
Autophagy controls DNA accessibility to immunoglobulin variable regions and centroblast dynamics [scATAC-seq]
GEO Series GSE218050. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
The DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
GEO Series GSE33206. Mus musculus. 9 samples. Type: Expression profiling by array.
Temporal Analyses Reveal a Pivotal Role for Sense and Anti-sense Enhancer RNAs in Coordinate Immunoglobulin Lambda Locus Activation
GEO Series GSE239925. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice
Spaceflight has been shown to suppress the adaptive immune response, altering the distribution and function of lymphocyte populations. B lymphocytes express highly specific and highly diversified receptors, known as immunoglobulins (Ig), that directly bind and neutralize pathogens. Ig diversity is achieved through the enzymatic splicing of gene segments within the genomic DNA of each B cell in a host. The collection of Ig specificities within a host, or Ig repertoire, has been increasingly characterized in both basic research and clinical settings using high-throughput sequencing technology (HTS). We utilized HTS to test the hypothesis that spaceflight affects the B-cell repertoire. To test this hypothesis, we characterized the impact of spaceflight on the unimmunized Ig repertoire of C57BL/6 mice that were flown aboard the International Space Station (ISS) during the Rodent Research One validation flight in comparison to ground controls. Individual gene segment usage was similar between ground control and flight animals, however, gene segment combinations and the junctions in which gene segments combine was varied among animals within and between treatment groups. We also found that spontaneous somatic mutations in the IgH and Igκ gene loci were not increased. These data suggest that space flight did not affect the B cell repertoire of mice flown and housed on the ISS over a short period of time.
Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station
Spaceflight is known to affect immune cell populations. In particular, splenic B-cell numbers decrease during spaceflight and in ground-based physiological models. Although antibody isotype changes have been assessed during and after spaceflight, an extensive characterization of the impact of spaceflight on antibody composition has not been conducted in mice. Next Generation Sequencing and bioinformatic tools are now available to assess antibody repertoires. We can now identify immunoglobulin gene- segment usage, junctional regions, and modifications that contribute to specificity and diversity. Due to limitations on the International Space Station, alternate sample collection and storage methods must be employed. Our group compared Illumina MiSeq sequencing data from multiple sample preparation methods in normal C57Bl/6J mice to validate that sample preparation and storage would not bias the outcome of antibody repertoire characterization. In this report, we also compared sequencing techniques and a bioinformatic workflow on the data output when we assessed the IgH and Igκ variable gene usage. Our bioinformatic workflow has been optimized for Illumina HiSeq and MiSeq datasets, and is designed specifically to reduce bias, capture the most information from Ig sequences, and produce a data set that provides other data mining options.
Induction of the neuronal major histocompatibility complex class I and paired immunoglobulin-like receptor B pathway in the hippocampus with aging and cognitive decline
GEO Series GSE29511. Rattus norvegicus. 17 samples. Type: Expression profiling by array.
In the aftermath of stroke or myocardial infarction, neutrophil extracellular traps disrupt systemic immunoglobulin production
GEO Series GSE254410. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Murine study of combined LPS and modified immunoglobulins associated gene expression changes in vivo
GEO Series GSE55694. Mus musculus. 31 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.