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471
datasets available to search
ShareScore release 0.9.0
Dataset results
471 results for “Protein targets”
SIRT1 affects DNA methylation of polycomb group protein target genes (PCGTs), a hotspot of the epigenetic shift observed in ageing
GEO Series GSE53569. Homo sapiens. 9 samples. Type: Methylation profiling by genome tiling array.
Remodeling of oncogenic transcriptomes by small-molecules targeting the RNA-binding protein NONO
GEO Series GSE198212. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Protein neddylation as a therapeutic target in pulomonary and extrapulonary small cell carcinomas [JHU-LX108]
GEO Series GSE171250. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Assessment of on- and off-target effects of dSpCas9-DNMT3A and dSpCas9-TET1 fusion proteins and the impact of modulating promoter strength on the specificity of CRISPR/dCas9-based epigenetic editing t
GEO Series GSE126528. Homo sapiens. 20 samples. Type: Methylation profiling by array.
Protein neddylation as a therapeutic target in pulomonary and extrapulonary small cell carcinomas [MSK-LX227C]
GEO Series GSE171255. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
The E3 ubiquitin ligase HectD1 suppresses EMT and metastasis by targeting the +TIP protein ACF7 for degradation
GEO Series GSE100092. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
P7C3 targets eIF4A1 to alleviate hepatic fibrosis by inhibiting protein translation and autophagy in hepatic stellate cells
GEO Series GSE316758. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Specificity protein 6 governs human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements [RNA-seq]
GEO Series GSE236795. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Fast and robust characterization of RNA targets of RNA-binding proteins by RNA-editing strategy coupled with machine learning in human embryonic stem cells
GEO Series GSE244757. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
RAPID-SELEX identifies high-affinity RNA targets for chromatin binding proteins PARP1 and MeCP2
GEO Series GSE269538. synthetic construct. 12 samples. Type: Other.
Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Proteins and Nuclear Responses for High-Light Acclimation.
GEO Series GSE211494. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Expression Profiles of MicroRNA, its genes and proteins targets and Stromal Genes in Aggressive Behavior Tumors from Young Patients with Breast Cancer.
GEO Series GSE77358. Homo sapiens. 42 samples. Type: Expression profiling by array.
Protein neddylation as a therapeutic target in pulomonary and extrapulonary small cell carcinomas
GEO Series GSE171262. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Nuclear matrix associated protein SMAR1 attenuated acute graft-versus-host disease by targeting JAK-STAT signaling in CD4+ T cells
GEO Series GSE229933. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target
<p>In this dataset, we have validated and explored the interaction between the SARS-CoV-2 M protein and the cellular protein PCNA, an interaction that was previously described by another proteomics study (Gordon et al., 2020). PCNA is an important nuclear protein involved in DNA replication and repair in the cell. The M-protein-PCNA interaction characterized here impacted the cell physiology, including increased localization of PCNA in the cytoplasm and associated DNA damage markers. These phenomena may have consequences for the fate of cells infected with SARS-CoV-2 and for the outcomes of COVID-19, such as persistent DNA damage after the infection. Finally, we show that inhibitors of PCNA and cell nuclear transport present effects in SARS-CoV-2 replication in vitro. Similar results have been presented by other RNA viruses in the literature. In sum, this study sheds light on novel molecular mechanisms of SARS-CoV-2 replication.</p>
In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [eCLIPseq]
GEO Series GSE127944. Mus musculus. 4 samples. Type: Other.
Nuclear matrix associated protein SMAR1 attenuated acute graft-versus-host disease by targeting JAK-STAT signaling in CD4+ T cells [ATAC-Seq]
GEO Series GSE229932. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Analysis of microRNA expression profiles and prediction of target gene signaling pathways in familial hypertrophic cardiomyopathy with myosin-binding protein C3 (MYBPC3) gene mutations
GEO Series GSE150078. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RBP Footprint Grand Challenge: An evaluation of novel computational approaches to RNA-binding protein target prediction from structural data
GEO Series GSE227455. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Antihistamine Drug Ebastine inhibits cancer growth by targeting Polycomb Group Protein EZH2
GEO Series GSE153652. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.