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1,286 results for “Spinal cord injury”
Effect of Sham Anti-inflammatory Diet on Inflammation After Spinal Cord Injury
ClinicalTrials.gov study NCT04271904. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Mental health in individuals with spinal cord injury: the role of socioeconomic conditions and social relationships
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Data from: Labor market integration of people with disabilities: results from the Swiss Spinal Cord Injury Cohort Study
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Data from: Empirical targets for acute hemodynamic management of individuals with spinal cord injury
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Data from: High-dose methylprednisolone for acute traumatic spinal cord injury: A meta-analysis
Objective Due to the continuing debates on the utility of high-dose methylprednisolone (MP) early after acute spinal cord injury (ASCI), we aim to evaluate the therapeutic and adverse effects of high-dose MP according to NASCIS-2 dosing protocol in comparison to no steroids on patients with ASCI, by performing a meta-analysis on the basis of the current available clinical trials. Methods We searched PubMed and Cochrane Library (to May 22 2018) for studies comparing neurological recoveries, adverse events and in-hospital costs between ASCI patients who underwent high-dose MP treatment or not. Data were synthesized with corresponding statistical models according to the degree of heterogeneity. Results We enrolled 16 studies (1863 participants) including 3 RCTs and 13 observational studies. Pooled results indicated that MP was not associated with an increase in motor score improvement (RCTs: p = 0.84; Observational studies: p = 0.44) and incidence of recovery by at least one grade on the ASIA Impairment Scale (AIS) or Frankel (p=0.53). Meanwhile, MP did not lead to better sensory recovery (p=0.07). However, MP was associated with a significant higher incidence of gastrointestinal hemorrhage (p=0.04) and respiratory tract infection (p=0.01). The difference in the overall in-hospital costs between MP and control groups was not statistically significant (p=0.78). Conclusions Based on the current evidence, high-dose MP treatment, in comparison to controls, does not contribute to better neurological recoveries but may increase the risk of adverse events in patients with ASCI. Therefore, we recommend against routine use of high-dose MP early after ASCI.
Data from: Can microstructural MRI detect subclinical tissue injury in subjects with asymptomatic cervical spinal cord compression? a prospective cohort study
Objectives: Degenerative cervical myelopathy (DCM) involves extrinsic spinal cord compression causing tissue injury and neurological dysfunction. Asymptomatic spinal cord compression (ASCC) is more common but its significance is poorly defined. This study investigates if: 1) ASCC can be automatically diagnosed using spinal cord shape analysis; 2) multiparametric quantitative MRI can detect similar spinal cord tissue injury as previously observed in DCM. Design: Prospective observational longitudinal cohort study. Setting: Single centre, tertiary care and research institution. Participants: 40 neurologically intact subjects (19 female, 21 male) divided into groups with and without ASCC. Interventions: None. Outcome Measures: Clinical assessments: modified Japanese Orthopedic Association (mJOA) score and physical examination. 3T MRI assessments: automated morphometric analysis compared with consensus ratings of spinal cord compression, and measures of tissue injury: cross-sectional area (CSA), diffusion fractional anisotropy (FA), magnetization transfer ratio (MTR), and T2-weighted imaging white to grey matter signal intensity ratio (T2WI WM/GM) extracted from rostral (C1-3), caudal (C6-7), and maximally compressed levels (MCL). Results: ASCC was present in 20/40 subjects. Diagnosis with automated shape analysis showed area under the curve > 97%. Five MRI metrics showed differences suggestive of tissue injury in ASCC compared with uncompressed subjects (p<0.05), while a composite of all 10 measures (average of z scores) showed highly significant differences (p=0.002). At follow-up (median 21 months), two ASCC subjects developed DCM. Conclusions: ASCC appears to be common and can be accurately and objectively diagnosed with automated morphometric analysis. Quantitative MRI appears to detect subclinical tissue injury in ASCC prior to the onset of neurological symptoms and signs. These findings require further validation, but offer the intriguing possibility of pre-symptomatic diagnosis and treatment of DCM and other spinal pathologies. Registration: Not registered.
Natural hydrogels and spinal cord injury treatment
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Natural hydrogels and spinal cord injury treatment
<p>PRISMA 2020 Checklist</p>
Trajectory Based Classification of Recovery In Sensorimotor Complete Traumatic Cervical Spinal Cord Injury – Individual Recovery Trajectory Data
<p><b>Objective</b></p> <p>To test the hypothesis that sensorimotor complete traumatic cervical spinal cord injury is a heterogenous clinical entity comprising several subpopulations that follow fundamentally different trajectories of neurological recovery.</p> <p><b>Methods</b></p> <p>We analyzed demographic and injury data from 655 patients who were pooled from four prospective longitudinal multicenter studies. Group based trajectory modeling was applied to model neurological recovery trajectories over the initial 12-months postinjury and to identify predictors of recovery trajectories. Neurological outcomes included: Upper Extremity Motor Score, Total Motor Scores and AIS grade improvement.</p> <p><b>Results </b></p> <p>The analysis identified three distinct trajectories of neurological recovery. These clinical courses included: (1) Marginal recovery trajectory: characterized by minimal or no improvement in motor strength or change in AIS grade status (remained grade A); (2) Moderate recovery trajectory: characterized by low baseline motor scores that improved approximately 13 points; or AIS conversion of one grade point; (3) Good recovery trajectory: characterized by baseline motor scores in the upper quartile that improved to near maximum values within three months of injury. Patients following the moderate or good recovery trajectories were of younger age, had more caudally located injuries, a higher degree of preserved motor and sensory function at baseline examination and exhibited a greater extent of motor and sensory function in the zone of partial preservation.</p> <p><b>Conclusion</b></p> <p>Cervical complete SCI can be classified into one of three distinct subpopulations with fundamentally different trajectories of neurological recovery. This study defines unique clinical phenotypes based on potential for recovery, rather than baseline severity of injury alone. This approach may prove beneficial in clinical prognostication and in the design and interpretation of clinical trials in SCI.</p>
Preventing Pressure Ulcers in Veterans With Spinal Cord Injury (SCI)
ClinicalTrials.gov study NCT00105859. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Treatment of Spinal Cord Injury Using Autologous Concentrated Growth Factors
ClinicalTrials.gov study NCT07253233. IPD Sharing: NO. Countries: 0. Publications: 13.
Diaphragm Pacing in Individuals With Spinal Cord Injuries
ClinicalTrials.gov study NCT04179799. IPD Sharing: NO. Countries: 1. Publications: 0.
The Influence of Dry Needling for Hypertonia and Spasticity Treatment on Neuropathic Pain in Lower Extremity of Spinal Cord Injury: A Case Series Study
ClinicalTrials.gov study NCT06954688. IPD Sharing: YES. Countries: 1. Publications: 0.
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
ClinicalTrials.gov study NCT00262496. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
ClinicalTrials.gov study NCT02469675. IPD Sharing: YES. Countries: 1. Publications: 0.
Two Devices for Reflex Voiding Following Spinal Cord Injury
ClinicalTrials.gov study NCT00662207. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pilot Study of Fosamax in Spinal Cord Injury
ClinicalTrials.gov study NCT01131884. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Respiratory Resistance Training on Sleep Quality in Persons With Spinal Cord Injury
ClinicalTrials.gov study NCT00629850. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Enhancing STDP After Spinal Cord Injury
ClinicalTrials.gov study NCT02701777. IPD Sharing: NO. Countries: 1. Publications: 0.
Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.
ClinicalTrials.gov study NCT00320281. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.