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4,495
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Dataset results
4,495 results for “clinical evaluation”
Saturation genome editing-based functional evaluation and clinical 2 classification of BRCA2 single nucleotide variants
GEO Series GSE270424. Homo sapiens. 144 samples. Type: Other.
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease (human)
GEO Series GSE119699. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
A Randomized, Double Blinded, Placebo-Controlled Clinical Trial Evaluating the Efficacy and Safety of anti-SARS-CoV-2 Convalescent Plasma in Hospitalized Patients (CONTAIN COVID-19)
<p>This dataset contains de-identified patient data of 941 patients from 21 centers across the United States who were enrolled in the CONTAIN COVID-19 randomized controlled trial that ran from 4/17/2020-3/15/2021. The information in this dataset was used to conduct the analysis reported in the CONTAIN COVID-19 manuscript published in JAMA Internal Medicine (doi: 10.1001/jamainternmed.2021.6850) and includes demographic information, baseline history, baseline medications, baseline laboratory values, clinical status based on the WHO 11-point scale at 14 and 28 days after randomization, antibody titers, randomization arms.</p>
Dataset related to article "Prospective evaluation of the role of imaging techniques and TMPRSS2:ERG mutation for the diagnosis of clinically significant prostate cancer "
<p>This record contains raw data related to article “Prospective evaluation of the role of imaging techniques and TMPRSS2:ERG mutation for the diagnosis of clinically significant prostate cancer"</p> <p>Abstract</p> <p><strong>Objectives: </strong> To test the hypothesis of a relationship between a specific genetic lesion (T2:ERG) and imaging scores, such as PI-RADS and PRI-MUS, and to test the effectiveness of these parameters for the diagnosis of prostate cancer (PCa) and clinically significant PCa (csPCa).</p> <p><strong>Materials and methods: </strong> This is a prospective study of men with suspected PCa enrolled between 2016 and 2019 at a high-volume tertiary hospital. Patients underwent systematic US-guided biopsy, plus targeted biopsy if they were presenting with >=1 suspicious lesion (PI-RADS>2) at mpMRI or PR-IMUS >2 at micro-ultrasound assessment. For each patient, one core from the highest PI-RADS or PRI-MUS lesion was collected for T2:ERG analysis. Multivariable logistic regression models (LRMs) were fitted for csPCa with a clinical model (age, total PSA, previous biopsy, family history for PCa), a clinical plus PI-RADS, clinical plus T2:ERG, clinical plus PI-RADS plus T2:ERG, and T2:ERG plus PI-RADS alone.</p> <p><strong>Results: </strong> The cohort consists of 158 patients: 83.5% and 66.2% had respectively a diagnosis of PCa and csPCa after biopsy. A T2:ERG fusion was found in 37 men and 97.3% of these patients harbored PCa, while 81.1% were diagnosed with csPCa. SE of T2:ERG assay for csPCa was 28.8%, SP 87.0%, NPV 38.8%, and PPV 81.1%. Of 105 patients who performed mpMRI 93.% had PIRADS ≥3. SE of mpMRI for csPCa was 98.5%, SP was 12.8%, NPV was 83.3%, and PPV was 65.7%. Among 67 patients who were subjected to micro-US, 90% had a PRI-MUS ≥3. SE of micro-US for csPCa was 89.1%, SP was 9.52%, NPV was 28.6%, and PPV was 68.3%. At univariable LRM T2:ERG was confirmed as independent of mpMRI and micro-US result (OR 1.49, p=0.133 and OR 1.82, p=0.592, respectively). At multivariable LRM the clinical model alone had an AUC for csPCa of 0.74 while the clinical model including PI-RADS and T2:ERG achieved an AUC of 0.83.</p> <p><strong>Conclusions: </strong> T2:ERG translocation and imaging results are independent of each other, but both are related csPCa. To evaluate the best diagnostic work-up for PCa and csPCa detection, all available tools (T2:ERG detection and imaging techniques) should be employed together as they appear to have a complementary role.</p>
MRI in Evaluating the Effect of Efaproxiral on the Brain in Patients With Recurrent or Progressive Glioma Enrolled on Clinical Trial NABTT-9806
ClinicalTrials.gov study NCT00433472. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Clinical Evaluation of Cardiac Resynchronization Therapy (CRT) Using the Ovatio CRT Implantable Cardioverter-defibrillator (ICD) System
ClinicalTrials.gov study NCT00528320. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Multicenter, Randomized, Double-blind, Placebo-parallel-controlled Phase II Clinical Study Evaluating the Efficacy and Safety of HRS9531 Injection in Obese Subjects With Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT06595797. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Prospective Clinical Evaluation of ASR/Re-Cap Resurfacing Arthroplasty
ClinicalTrials.gov study NCT00376610. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Evaluation of the Care On Line Thermometer
ClinicalTrials.gov study NCT00544141. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Multicenter, Open-Label Continuation Trial Evaluating the Tolerability and Activity of Depsipeptide (FK228) in Patients That Have Completed a Prior Clinical Study With Depsipeptide.
ClinicalTrials.gov study NCT00299351. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases
ClinicalTrials.gov study NCT00242554. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease
GEO Series GSE119723. Caenorhabditis elegans; Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of a novel clinical platform for cardiovascular drug development
GEO Series GSE37824. Homo sapiens. 249 samples. Type: Expression profiling by array.
Genomic Evaluation of Multiparametric Magnetic Resonance Imaging -visible and -nonvisible Lesions in Clinically Localized Prostate Cancer
GEO Series GSE101908. Homo sapiens. 42 samples. Type: Methylation profiling by genome tiling array.
Clinical evaluation of an over-the-counter hearing aid (TEO First®) in elderly patients suffering of mild to moderate hearing loss
<p>de-identifed dataset concerning Current Controlled Trials NCT01815788</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.