Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
453
datasets available to search
ShareScore release 0.9.0
Dataset results
453 results for “Idiopathic pulmonary fibrosis”
Global DNA methylation pattern of fibroblasts in idiopathic pulmonary fibrosis: relationship to gene expression
GEO Series GSE107226. Homo sapiens. 12 samples. Type: Methylation profiling by array.
Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1+ macrophages
GEO Series GSE252465. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Idiopathic pulmonary fibrosis (IPF)
GEO Series GSE195770. Homo sapiens. 8 samples. Type: Expression profiling by array.
MicroRNA expression data from lung tissue of Idiopathic Pulmonary Fibrosis
GEO Series GSE75647. Homo sapiens. 7 samples. Type: Expression profiling by array.
Expression data from lung resident mesenchymal stem cells from idiopathic pulmonary fibrosis patients and control subjects
GEO Series GSE240470. Homo sapiens. 8 samples. Type: Expression profiling by array.
To examine the expression of Sulf1 and Sulf2, as well as other glycan-related genes, in human Idiopathic pulmonary fibrosis (IPF) lungs compared to normal lung samples
GEO Series GSE31934. Homo sapiens. 6 samples. Type: Expression profiling by array.
Transcriptome sequencing of lncRNAs, circRNAs, miRNAs, mRNAs and interaction network constructing in acute exacerbation of idiopathic pulmonary fibrosis
GEO Series GSE221937. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Transcriptomic analysis of Platycodin D (PD)-improved idiopathic pulmonary fibrosis (IPF) mice
GEO Series GSE317792. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Differential Lysotracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis
GEO Series GSE185691. Homo sapiens. 14 samples. Type: Expression profiling by array.
INFLUENCE OF CHEST WALL CONFORMATION ON SPIROMETRY PARAMETERS AND OUTCOME IN MILD TO MODERATE IDIOPATHIC PULMONARY FIBROSIS
<p>Extrinsic causes of restrictive lung syndrome in idiopathic pulmonary fibrosis (IPF) patients have been poorly investigated. We aimed to investigate the influence of the anterior chest wall deformity, noninvasively assessed by modified Haller index (MHI), on spirometry parameters and outcome in a consecutive population of patients with mild-to-moderate IPF.</p> <p>60 consecutive IPF patients (73.8 ± 6.6 yrs, 45 males) were included in this retrospective study. All patients underwent physical examination, spirometry, blood tests, conventional transthoracic echocardiography and MHI assessment (chest transverse diameter over the distance between sternum and spine) at basal evaluation. During follow-up, we evaluated the composite endpoint of 1) pulmonary or cardiovascular hospitalizations; 2) all-cause mortality.</p> <p>IPF patients with concave-shaped chest wall (MHI >2.5) (36.7% of total) and those with normal chest shape (MHI ≤2.5) (63.3%) were separetely analyzed. In comparison to IPF patients with MHI ≤2.5, those with MHI >2.5: were less likely to be men and smokers; had a more severe restrictive pattern; had significantly smaller cardiac chamber dimensions and significantly higher systolic pulmonary artery pressure (51.9±15.1 vs 42.4±14.3 mmHg, p=0.02). Mean follow-up time was 2.5±1.4 yrs. During follow-up, 13 deaths and 16 pulmonary or cardiovascular hospitalizations were detected. At multivariate Cox regression analysis, concave-shaped chest wall (MHI>2.5) (HR 4.55, 95%CI 1.02-20.4), increased C-reactive protein (HR 1.68, 95%CI 1.08-2.61) and absence of beta-blocker therapy (HR 0.13, 95%CI 0.01-0.26) were independently associated to the investigated outcome.</p> <p>MHI assessment and implementation may help the clinician to identify, among IPF patients, those with poorer prognosis over a medium-term follow-up.</p>
INCREMENTAL PROGNOSTIC VALUE OF ARTERIAL ELASTANCE IN MILD-TO-MODERATE IDIOPATHIC PULMONARY FIBROSIS
<p><strong>PURPOSE: </strong>Previous reports suggested that poor pulmonary function was associated with increased arterial elastance (Ea) in patients with chronic obstructive pulmonary disease and systemic sclerosis. The mechanisms connecting pulmonary function and Ea have not yet been accurately studied in patients with idiopathic pulmonary fibrosis (IPF). The present study was designed to assess Ea in IPF patients without chronic severe pulmonary hypertension and to determine its prognostic role over a medium-term follow-up.</p> <p><strong>METHODS: </strong>This retrospective study included 60 consecutive patients with mild-to-moderate IPF (73.8±6.6 yrs, 75% males) and 60 controls matched by age, sex and cardiovascular risk factors. All patients underwent physical examination, spirometry, blood tests, modified Haller index (MHI, chest transverse diameter over the distance between sternum and spine) assessment, conventional transthoracic echocardiography implemented with speckle tracking analysis of left atrial positive global strain (LA-GSA+) and finally carotid Doppler ultrasonography, at basal evaluation. The effective arterial elastance index (EaI) was calculated as the ratio of end-systolic pressure to stroke volume index. During follow-up period, we evaluated the composite endpoint of 1) pulmonary or cardiovascular hospitalizations; 2) all-cause mortality.</p> <p><strong>RESULTS: </strong>At baseline, EaI was significantly higher in IPF patients than controls (4.1±1.3 vs 3.5±1.0 mmHg/ml/m<sup>2</sup>, p=0.01). EaI was strongly correlated to the following variables: C-reactive protein (CRP) (r=0.86), forced vital capacity (FVC) (r=-0.91), E/e’ ratio (r=0.91), LA-GSA+ (r=-0.92), common carotid artery-cross sectional area (CCA-CSA) (r=0.89) and MHI (r=0.86), in IPF patients. Mean follow-up time was 2.4±1.3 yrs. During follow-up, 12 patients died and 17 were hospitalized due to major adverse clinical events. At univariate Cox analysis, CRP (HR 1.51, 95%CI 1.25-1.82), FVC (HR 0.88, 95%CI 0.85-0.91), LA-GSA+ (HR 0.85, 95%CI 0.77-0.94), CCA-CSA (HR 1.12, 95%CI 1.03-1.22) and EaI (HR 2.43, 95%CI 1.75-3.37) were significantly associated with outcome. At multivariate Cox analysis, only EaI (HR 1.60, 95%CI 1.03-2.50) retained statistical significance. An EaI ≥4 mmHg/ml/m<sup>2 </sup>showed 100% sensitivity and 99.4% specificity for predicting outcome (AUC=0.98).</p> <p><strong>CONCLUSIONS: </strong>In patients with mild-to-moderate IPF, an EaI ≥4 mmHg/ml/m<sup>2 </sup>is a negative prognostic factor over a medium-term follow-up.</p>
Early left atrial dysfunction in idiopathic pulmonary fibrosis patients without chronic right heart failure
<p>Raw data related to the article.</p> <p>Abstract</p> <p>No data are actually available regarding the left atrial (LA) functional assessment by two-dimensional speckle tracking<br> echocardiography (2D-STE) in early-stage idiopathic pulmonary fibrosis (IPF). The primary end-point of our study was to<br> assess whether global LA peak strain (GLAPS), measured by 2D-STE analysis, may detect early alterations in LA function<br> in IPF patients without right heart failure (RHF). Between September 2017 and January 2019, 50 consecutive IPF patients<br> (73.8 ± 6.8 years, 36 males) without chronic RHF and 30 controls matched by age, sex and cardiovascular risk factors, were<br> enrolled in an observational retrospective case–control study. All patients underwent a complete echocardiographic study<br> implemented with 2D-STE analysis. GLAPS, left ventricular (LV) global longitudinal strain (GLS), right atrial (RA) reservoir<br> strain (GSA+) and right ventricular (RV)-GLS were obtained in each patient. LVFP were significantly increased in<br> IPF patients in comparison to controls (average E/e′ ratio 14.4 ± 3.0 vs 9.6 ± 1.5, p < 0.0001), while LV-GLS was slightly<br> reduced in IPF patients compared to controls (19.4 ± 3.6% vs 21.0 ± 2.2%, p = 0.03).Moreover, GLAPS was significantly<br> impaired in IPF patients in comparison to controls (18.4 ± 3.7% vs 28.4 ± 5.6%, p < 0.0001).Finally, the two groups of<br> patients did not show any statistically significant difference in both RA-GSA + (23.9 ± 3.7% vs 24.5 ± 4.0%, p = 0.49)<br> and RV-GLS (− 22.6 ± 3.3% vs − 23.5 ± 3.0%, p = 0.22). Notably, LV-GLS was strongly inversely correlated both with<br> RV/LV basal diameter ratio and TRV in IPF patients (r = − 0.87 and − 0.82, respectively) but not in controls (r = − 0.29<br> and − 0.27, respectively). This finding highlights a likely process of ventricular interdependence in non-advanced IPF, with<br> consequent LV diastolic dysfunction and secondary impairment in LV-GLS and GLAPS. Early LA reservoir dysfunction in<br> IPF patients may be secondary to LV diastolic dysfunction induced by ventricular interdependence and may develop before<br> RV diastolic and systolic dysfunction.</p>
Association between C‑reactive protein and carotid plaque in mild‑to‑moderate idiopathic pulmonary fibrosis
<p>Raw data related to the article</p> <p> </p> <p>Abstract<br> An association between C-reactive protein (CRP) levels and carotid plaque has never been investigated in idiopathic pulmonary<br> fibrosis (IPF). The aim of this study was to evaluate the extent of carotid atherosclerosis in mild-to-moderate IPF<br> and to assess its relationship to serum CRP. This observational retrospective case–control study included 60 consecutive<br> IPF patients (73.8 ± 6.6 years, 45 males) and 60 matched controls, examined between Sep 2017 and Jan 2019. All patients<br> underwent CRP assessment and a carotid Doppler ultrasonography. CRP levels were significantly higher in IPF patients than<br> controls (0.2 ± 0.09 mg/dl vs 0.09 ± 0.04 mg/dl, p < 0.0001). A total of 46 plaques were detected, with higher prevalence in<br> IPF patients than controls (38 vs 8, p < 0.0001). On univariate logistic regression the main variables independently associated<br> with carotid plaque were: age (HR 1.09, 95% CI 1.03–1.16, p = 0.006), hypertension duration (HR 1.05, 95% CI 1.01–1.09,<br> p = 0.01), diabetes duration (HR 1.09, 95% CI 1.01–1.18, p = 0.03), LDL-cholesterol (HR 1.07, 95% CI 1.04–1.10, p < 0.0001)<br> and finally CRP levels (HR 1.73, 95% CI 0.59–5.00, p < 0.0001). Multivariate logistic regression analysis revealed that<br> LDL-cholesterol (HR 1.05, 95% CI 1.01–1.08, p = 0.009) and CRP levels (HR 1.43, 95% CI 0.39–5.19, p < 0.0001) retained<br> statistical significance. Common carotid artery-intima media thickness was significantly correlated with CRP levels in IPF<br> patients (r = 0.86). SerumCRP might represent both an early marker and a potential therapeutic target for carotid atherosclerosis<br> in mild-to-moderate IPF.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.