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445 results for “arrhythmia”
IL-18 mediates sickle cell cardiomyopathy and inducible ventricular arrhythmias
GEO Series GSE89373. Mus musculus. 6 samples. Type: Expression profiling by array.
CMR for Identifying the Substrate of Ventricular Arrhythmia in Patients with Q1 Normal Echocardiography
<p>OBJECTIVES This study sought to determine whether cardiac magnetic resonance (CMR) may identify structural heart<br> disease (SHD) in patients with ventricular arrhythmia who had echocardiography ruled out pathological findings.<br> BACKGROUND Approximately one-half of sudden cardiac deaths are attributable to malignant VA. Echocardiography is<br> commonly used to identify SHD that is the most frequent substrate of VA.<br> Q6 METHODS A single-center prospective study was conducted in consecutive patients with significant VA, categorized as<br> >1,000 but <10,000 ventricular ectopic beats [VEB]s/24 h; $10,000 VEBs/24 h; nonsustained ventricular tachycardia,<br> sustained ventricular tachycardia (SVT), or a history of resuscitated cardiac arrest, and no pathological findings at<br> echocardiography, requiring a clinically indicated CMR. Primary endpoint was CMR detection of SHD. Secondary endpoints<br> were a composite of CMR detection of SHD and abnormal findings not specific for a definite SHD diagnosis.<br> RESULTS A total of 946 patients were enrolled (mean 41 16 years of age; 64% men). CMR studies were used to<br> diagnose SHD in 241 patients (25.5%) and abnormal findings not specific for a definite SHD diagnosis in 187 patients<br> (19.7%). Myocarditis (n ¼ 91) was the more frequent disease, followed by arrhythmogenic cardiomyopathy (n ¼ 55),<br> dilated cardiomyopathy (n ¼ 39), ischemic heart disease (n ¼ 22), hypertrophic cardiomyopathy (n ¼ 13), congenital<br> cardiac disease (n ¼ 10), left ventricle noncompaction (n ¼ 5), and pericarditis (n ¼ 5). The strongest univariate and<br> multivariate predictors of SHD on CMR images were chest pain (odds ratios [OR]: 2.52 and 2.38, respectively) and SVT<br> (ORs: 2.67 and 2.23, respectively).<br> CONCLUSIONS SHD was able to be identified on CMR imaging in a sizable number of patients with significant VA and<br> completely normal echocardiography. Chest pain and SVT were the strongest predictors of positive CMR imaging<br> results. </p>
Lack of association between heart period variability asymmetry and respiratory sinus arrhythmia in healthy and chronic heart failure individuals
<p>Dataset from De Maria B, Dalla Vecchia LA, Maestri R, Pinna GD, Parati M, Perego F, Bari V, Cairo B, Gelpi F, La Rovere MT, Porta A. Lack of association between heart period variability asymmetry and respiratory sinus arrhythmia in healthy and chronic heart failure individuals. PLoS One. 2021 Feb 16;16(2):e0247145. doi: 10.1371/journal.pone.0247145. PMID: 33592077; PMCID: PMC7886158.</p> <p>Abstract</p> <p>Temporal asymmetry is a peculiar aspect of heart period (HP) variability (HPV). HPV asymmetry (HPVA) is reduced with aging and pathology, but its origin is not fully elucidated. Given the impact of respiration on HPV resulting in the respiratory sinus arrhythmia (RSA) and the asymmetric shape of the respiratory pattern, a possible link between HPVA and RSA might be expected. In this study we tested the hypothesis that HPVA is significantly associated with RSA and asymmetry of the respiratory rhythm. We studied 42 middle-aged healthy (H) subjects, and 56 chronic heart failure (CHF) patients of whom 26 assigned to the New York Heart Association (NYHA) class II (CHF-II) and 30 to NYHA class III (CHF-III). Electrocardiogram and lung volume were monitored for 8 minutes during spontaneous breathing (SB) and controlled breathing (CB) at 15 breaths/minute. The ratio of inspiratory (INSP) to expiratory (EXP) phases, namely the I/E ratio, and RSA were calculated. HPVA was estimated as the percentage of negative HP variations, traditionally measured via the Porta's index (PI). Departures of PI from 50% indicated HPVA and its significance was tested via surrogate data. We found that RSA increased during CB and I/E ratio was smaller than 1 in all groups and experimental conditions. In H subjects the PI was about 50% during SB and it increased significantly during CB. In both CHF-II and CHF-III groups the PI was about 50% during SB and remained unmodified during CB. The PI was uncorrelated with RSA and I/E ratio regardless of the experimental condition and group. Pooling together data of different experimental conditions did not affect conclusions. Therefore, we conclude that the HPVA cannot be explained by RSA and/or I/E ratio, thus representing a peculiar feature of the cardiac control that can be aroused in middle-aged H individuals via CB.</p>
Dataset related to the article "Prior myocarditis and ventricular arrhythmias: The importance of scar pattern"
<p>This record contains raw data related to the article "Prior myocarditis and ventricular arrhythmias: The importance of scar pattern".</p> <p> </p> <p><em><strong>Abstract</strong></em></p> <p><strong>Background: </strong>Multiple studies have addressed the importance of anteroseptal scar in patients with nonischemic cardiomyopathy. However, this pattern has never been fully evaluated in patients with prior myocarditis.</p> <p><strong>Objective: </strong>The purpose of this study was to evaluate whether anteroseptal scar is associated with worse outcome in patients with prior myocarditis and how it affects the efficacy of catheter ablation (CA).</p> <p><strong>Methods: </strong>This was a retrospective study of consecutive patients with prior myocarditis and arrhythmic presentation. Cardiac magnetic resonance and electroanatomic voltage mapping were used to identify the scar pattern. Patients were referred for either CA or escalated antiarrhythmic drug (AAD) therapy. The main outcome was ventricular arrhythmia (VA)-free survival according to the presence of anteroseptal scar.</p> <p><strong>Results: </strong>A total of 144 consecutive patients with prior myocarditis were included. Mean age was 42.1 ± 14.9 years, and 58% were men. Ejection fraction was normal in 73% of patients. Anteroseptal scar was present in 44% of cases. Sixty-one patients (42%) underwent CA. Overall, at 2-year follow-up, VA-free survival was 77% in the CA group. After CA, the mean number of AADs taken by each patient decreased from 1.8 to 0.9 per day (p<0.001). The presence of anteroseptal scar was found to be an independent predictor of VA relapse both in patients treated with CA (hazard ratio [HR] 3.6; 95% confidence interval [CI] 1.1-11.4; P = .03) and in the overall population (HR 2.0; 95% CI 1.2-3.5; P = .02) .</p> <p><strong>Conclusion: </strong>In patients with prior myocarditis and VA, the presence of anteroseptal scar negatively predicts outcomes irrespective of treatment strategy.</p> <p> </p>
Respiratory Sinus Arrhythmia (RSA) stress response in preschool age varies by serotonin transporter polymorphism (5-HTTLPR): A preliminary report
<p>The serotonin transporter promoter region polymorphism (5-HTTLPR) has been implicated in stress regulation, with increased stress reactivity often being found in carriers of the low-expressing short (S) allele. Nevertheless, the role of the 5-HTTLPR in influencing parasympathetic stress reactivity, as indexed by Respiratory Sinus Arrhythmia (RSA), is still unknown. This study examined, for the first time, whether the 5-HTTLPR was associated with variations in RSA response to maternal separation in a sample of 69 healthy 5-year-old children. Preschoolers' RSA was measured during an age-adapted version of the Strange Situation Procedure (SSP). The 5-HTTLPR polymorphism was tested as a predictor of RSA dynamic response to the SSP through multilevel models. A significant interaction between 5-HTTLPR and SSP episodes was found. In particular, whereas a significant decrease in RSA levels was observed during the stranger episode in the whole sample, S allele carriers showed a significant decrease in RSA levels from the stranger episode to the first separation episode, followed by an increase for the rest of the procedure. Albeit preliminary, data support the view that the 5-HTTLPR may contribute to individual differences in RSA stress reactivity from preschool age.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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