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Dataset results
456 results for “mesothelioma”
A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With Malignant Pleural Mesothelioma
ClinicalTrials.gov study NCT01353482. IPD Sharing: Not stated. Countries: 0. Publications: 0.
IKK in mesothelioma
GEO Series GSE129984. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Expression profile of maliganant mesothelioma cell lines
GEO Series GSE34499. Homo sapiens. 20 samples. Type: Expression profiling by array.
DNA methylation-based machine learning classification distinguishes pleural mesothelioma from chronic pleuritis, pleural carcinosis, and pleomorphic lung carcinomas
GEO Series GSE203061. Homo sapiens. 76 samples. Type: Methylation profiling by genome tiling array.
Pharmacogenomic characterisation of a large collection of primary cell lines identifies novel therapeutic options for pleural mesothelioma
GEO Series GSE279871. Homo sapiens. 62 samples. Type: Methylation profiling by genome tiling array.
Gene expression of mesothelioma cell line ACC-Meso-4 treated with shRNA targeting chromobox (CBX) 6, 7, and 8.
GEO Series GSE126605. Homo sapiens. 8 samples. Type: Expression profiling by array.
Expression data upon treatment of human mesothelioma mouse model with nucleolin-targeted nanoparticle (PEGASEMP)
GEO Series GSE121205. Homo sapiens. 8 samples. Type: Expression profiling by array.
Copy number variations analysis by CytoscanHD array of 33 human pleural mesothelioma cell lines
GEO Series GSE134349. Homo sapiens. 33 samples. Type: Genome variation profiling by SNP array.
Affymetrix OncoScan FFPE Microarray data for Malignant Pleural Mesothelioma Samples
GEO Series GSE109305. Homo sapiens. 4 samples. Type: Genome variation profiling by SNP array.
Mithramycin Depletes Sp1 and Activates p53 to Mediate Senescence and Apoptosis of Pleural Mesothelioma Cells
GEO Series GSE64738. Homo sapiens. 45 samples. Type: Expression profiling by array.
Identification of novel markers for malignant pleural mesothelioma diagnosis
GEO Series GSE17310. Homo sapiens. 54 samples. Type: Expression profiling by array.
Dataset related to article "In-vivo imaging of methionine metabolism in patients with suspected malignant pleural mesothelioma."
<p>OBJECTIVES:</p> <p>In-vivo characterization of malignant pleural mesothelioma (MPM) with C-methionine PET/computed tomography (MET PET).</p> <p>METHODS:</p> <p>Between September 2014 and February 2016, 30 consecutive patients with clinical suspicion of MPM were prospectively recruited. The study was approved and registered at www.clinicaltrials.gov (<a href="http://clinicaltrials.gov/show/NCT02519049">NCT02519049</a>). Patients were evaluated at baseline with MET PET (experimental) and fluorine-18 fluorodeoxyglucose PET/computed tomography (FDG PET) (standard). Principal parameters analyzed were SUVmax, SUVmean, metabolic tumor volume (MTV), and metabolic tumor burden (MTB  =&thinsp;MTV ×SUVmean). The reference standard for diagnostic performance was based on histology.</p> <p>RESULTS:</p> <p>The presence of malignancy was confirmed in 29/30 patients: 23 (76.6%) with MPM (20 epithelioid, two biphasic, and one sarcomatoid), five (16.6%) with adenocarcinoma of the lung, and one (3.3%) with an undifferentiated carcinoma. In one case, diagnosis was benign pleural inflammation. All tumors showed increased uptake of C-methionine: median SUVmax, SUVmean, MTV, and MTB were, respectively, 5.70 [95% confidence interval (CI): 4.51-6.79], 3.15 (95% CI: 2.71-3.40), 33.85 (95% CI: 14.08-66.64), and 105.25 (95% CI: 41.77-215.25). Pathology data revealed MTV and MTB to be significantly higher in nonepithelioid histology (P < 0.05). The other parameters showed a homogeneous distribution across the tumor types. Overall, MET PET identified 49 lymph nodes, compared with 34 nodes on FDG PET, demonstrating a sensitivity of 91% (95% CI: 80-96%), a positive predictive value of 92% (95% CI: 82- 97%), and an accuracy of 85% (P = 0.0042).</p> <p>CONCLUSIONS:</p> <p>MET PET is able to characterize MPM lesions regardless of histology. This technique shows higher sensitivity than FDG PET for the identification of secondary lymph nodes.</p>
Dataset related to article "Epithelioid pleural mesothelioma is characterized by tertiary lymphoid structures in long survivors: results from the MATCH study"
<p>This record contains data related to article “Epithelioid pleural mesothelioma is characterized by tertiary lymphoid structures in long survivors: results from the MATCH study”.</p> <p>The abstract is not yet available.</p> <p> </p>
Dataset related to article "Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma"
<p>This record contains raw data related to article "Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma"</p><p><strong>Background: </strong>Malignant Pleural Mesothelioma (MPM) is an aggressive cancer of the mesothelial lining associated with exposure to airborne non-degradable asbestos fibers. Its poor response to currently available treatments prompted us to explore the biological mechanisms involved in its progression. MPM is characterized by chronic non-resolving inflammation; in this study we investigated which inflammatory mediators are mostly expressed in biological tumor samples from MPM patients, with a focus on inflammatory cytokines, chemokines and matrix components.</p><p><strong>Methods: </strong>Expression and quantification of Osteopontin (OPN) was detected in tumor and plasma samples of MPM patients by mRNA, immunohistochemistry and ELISA. The functional role of OPN was investigated in mouse MPM cell lines <i>in vivo</i> using an orthotopic syngeneic mouse model.</p><p><strong>Results: </strong>In patients with MPM, the protein OPN was significantly more expressed in tumors than in normal pleural tissues and predominantly produced by mesothelioma cells; plasma levels were elevated in patients and associated with poor prognosis. However, modulation of OPN levels was not significantly different in a series of 18 MPM patients receiving immunotherapy with durvalumab alone or with pembrolizumab in combination with chemotherapy, some of whom achieved a partial clinical response. Two established murine mesothelioma cell lines: AB1 and AB22 of sarcomatoid and epithelioid histology, respectively, spontaneously produced high levels of OPN. Silencing of the OPN gene (<i>Spp1</i>) dramatically inhibited tumor growth <i>in vivo</i> in an orthotopic model, indicating that OPN has an important promoting role in the proliferation of MPM cells. Treatment of mice with anti-CD44 mAb, blocking a major OPN receptor, significantly reduced tumor growth <i>in vivo</i>.</p><p><strong>Conclusion: </strong>These results demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumor progression <i>in vivo</i>. These findings have translational potential to improve the therapeutic response of human MPM.</p>
MesoHET (Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma)
GEO Series GSE175769. Homo sapiens. 10 samples. Type: Methylation profiling by genome tiling array.
Expression data from in vitro healthy cells and malignant pleural mesothelioma cell lines infected by oncolytic attenuated measles virus or treated by exogenous type I interferon
GEO Series GSE117668. Homo sapiens. 48 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.