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496
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ShareScore release 0.9.0
Dataset results
496 results for “metabolic activity”
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging [Quantseq_cell]
GEO Series GSE298195. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
IL-27-induced shifts in metabolism orchestrate the polarization of alternatively activated macrophages and mitigate inflammatory pain
GEO Series GSE285607. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Microbiome-dependent tryptophan metabolism suppresses inflammatory immunity in the pancreatic tumor microenvironment by activation of the aryl hydrocarbon receptor [scRNA-seq]
GEO Series GSE171602. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [RNA-seq]
GEO Series GSE220963. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [WES]
GEO Series GSE270778. Homo sapiens; Mus musculus. 14 samples. Type: Other.
Endothelial Cell-specific Activation of NOX1 Drives Obesity and Metabolic Syndrome via Skeletal Muscle Mitochondrial Dysfunction with Novel Genetic Signatures
GEO Series GSE316731. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12
GEO Series GSE296508. Mus musculus. 57 samples. Type: Expression profiling by high throughput sequencing.
Interactions of C4 subtype metabolic activities and transport in maize are revealed through the characterization of dct2 mutants
GEO Series GSE67722. Zea mays. 24 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program
GEO Series GSE220966. Mus musculus. 83 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other.
Metabolic licensing of quiescent glioblastoma activation and immune evasion via astrocyte-mitochondria shuttle [RNA-Seq]
GEO Series GSE316867. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Detection of metabolic activity in dormant conidia of Aspergillus niger and use of growth inhibitors to study transient developmental changes.
GEO Series GSE79745. Aspergillus niger. 6 samples. Type: Expression profiling by high throughput sequencing.
Microbiome-dependent tryptophan metabolism suppresses inflammatory immunity in the pancreatic tumor microenvironment by activation of the aryl hydrocarbon receptor [RNA-seq]
GEO Series GSE171601. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Okra polysaccharide activates PPAR-γ signaling to attenuate metabolic-associated fatty liver disease in mice
GEO Series GSE273255. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell genomics highlight MYC-upregulation, metabolic activation, and altered cell interactions in T-PLL progression
GEO Series GSE238130. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
The protein kinase activity of NME7 activates one-carbon metabolism through positively regulating wnt/β-catenin signaling
GEO Series GSE165985. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation Induced Metabolic networks in Human T cells
GEO Series GSE129829. Homo sapiens. 89 samples. Type: Expression profiling by high throughput sequencing.
Comparative evaluation of metabolic, electrophilic, and immunologic effects of itaconate and its ester derivatives on macrophage activation
GEO Series GSE145950. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [WES]
GEO Series GSE220964. Mus musculus. 28 samples. Type: Other.
Time series transcriptomes resolve metabolic pathways underlying crocin's anti-cancer activity | Dataset: sequencing reads (controls); Kallisto counts/TPMs
<p>This repository is deprecated. Controls are now here: https://zenodo.org/records/13822024 and the Kallisto and ShinyGO analyses are here: https://zenodo.org/records/15804191</p> <p> </p> <p>Liver cancer can be treated with natural products, including saffron. The exact mechanism for the components of saffron, including crocin, to eliminate malignancy in HCC cells is not known. We used response screening from time series transcriptomic datasets to decipher the underlying mechanisms responsible for crocin’s anti-cancer activity. We treated HCC cells with 1 and 2 mM crocin for 2, 6, 12, and 24 hours and examined transcriptomic profiles at each timepoint compared to controls. The effect size was strongest at two hours and 1 mM crocin; later timepoints and the 2 mM dose showed similar responses, but the overall effect was diminished after two hours post-treatment. We observed the upregulation of transcripts for fatty acid oxidation enzymes, mitochondrial carnitine transpoart systems, bile acid synthesis, and cholesterol metabolism to varying degrees at all timepoints tested after crocin treatment. Pathway enrichment analyses showed that pathways for DNA damage checkpoint activation and senescence induction were upregulated while a variety of pro-proliferation pathways were downregulated. We saw 52 genes involved in non-alcoholic fatty liver disease down-regulated after 24 hours post-treatment (enrichment FDR p = 8 x 10<sup>8</sup>), indicating a reversal of many pathways promoting carcinogenesis after crocin treatment. The significant upregulation of senescence and autophagy genes was contrasted with the significant down-regulation of spliceosomal machinery genes at all time points after crocin treatment. Interestingly, the cell fate-protecting PAX transcription factor was significantly upregulated while ELK oncogenes were downregulated after crocin treatment. Overall, the data outline an intricate cellular response leading to HCC spliceosome repression and induced senescence after crocin treatment. Our findings help to explain the cancer-fighting effects of saffron and outline an example of antioxidant ‘swamping’ in cancer cells by natural products.</p>
E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT [Polysome-seq]
GEO Series GSE278444. Mus musculus. 33 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.