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482
datasets available to search
ShareScore release 0.9.0
Dataset results
482 results for “Pituitary”
Malnutrition affects the physiological status and function of pituitary gland in pregnant ewes
GEO Series GSE220723. Ovis aries. 10 samples. Type: Expression profiling by high throughput sequencing.
Effect of DES-treated Ept congenic rat lines on gene expression in the anterior pituitary gland.
GEO Series GSE4080. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
MIR205HG- and miR-205- knockout mice comparisons of gene expression in the epithelial tissues of the skin and from the pituitary
GEO Series GSE126943. Mus musculus. 18 samples. Type: Expression profiling by array.
RNA-seq reveals differentially expressed genes involved in the hypothalamus and pituitary function affecting divergent residual feed intake in slow-growing Korat chicken
GEO Series GSE278826. Gallus gallus. 20 samples. Type: Expression profiling by high throughput sequencing.
Expression data from rat pituitary adenoma cells
GEO Series GSE101012. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
Genome-wide maps of chromatin state in LbetaT2 cells or in the pituitary tissues of wild-type and Foxk2 knockout mice.
GEO Series GSE130615. Mus musculus. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Transcriptional Profiling of the Anterior Pituitary Gland of Genetically Selected Fat and Lean Chickens
GEO Series GSE26584. Gallus gallus. 32 samples. Type: Expression profiling by array.
Rathke’s Cleft-Like Cysts Arise From Isl1 Deletion in Murine Pituitary Progenitors
GEO Series GSE149019. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparative anterior pituitary miRNA and mRNA expression profiles of Bama minipigs and Landrace pigs reveal potential molecular network involved in animal postnatal growth [miRNA array]
GEO Series GSE68489. Sus scrofa. 2 samples. Type: Non-coding RNA profiling by array.
Bovine pituitary gland gene expression database of Polish-HF, Polish-Red and Hereford cattle breeds.
GEO Series GSE114230. Bos taurus. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene expression data from NECA (5/-N-ethylcarboxamidoadenosine) treated murine pituitary folliculostellate cells(TtT/GF)
GEO Series GSE15564. Mus musculus. 9 samples. Type: Expression profiling by array.
Regulation of pituitary gene expression by adrenalectomy
GEO Series GSE5879. Mus musculus. 2 samples. Type: Expression profiling by SAGE.
Transcriptome analysis of the brain (ventral part of telenchephalon, hypothalamus and pituitary) of wild-type medaka and phod1 knockout medaka kept under short-day or long-day conditions
GEO Series GSE284109. Oryzias latipes. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparison of gene expression profiles between GnRH-treated and control rat pituitary organ cultures
GEO Series GSE4865. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Genome wide analysis of circulating miRNAs in growth hormone secreting pituitary neuroendocrine tumor patients' plasma
GEO Series GSE196647. Homo sapiens. 83 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Comparative anterior pituitary miRNA and mRNA expression profiles of Bama minipigs and Landrace pigs reveal potential molecular network involved in animal postnatal growth
GEO Series GSE68491. Sus scrofa. 4 samples. Type: Non-coding RNA profiling by array; Expression profiling by high throughput sequencing.
FSHβ links photoperiodic signalling in the mediobasal hypothalamus and pituitary gland to seasonal reproduction in Japanese quail.
GEO Series GSE241775. Coturnix japonica. 108 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"
<p>This record contains raw data related to article "Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion"</p> <p><strong>Abstract</strong></p> <p>Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures.</p> <p>Following the identification of a loss-of-function variant (p.Arg703Gln) in the <em>PAM </em>gene in a family with pituitary gigantism, we investigated 299 individuals with sporadic PAs and 17 familial isolated pituitary adenomas kindreds for <em>PAM </em>variants. <em>PAM </em>encodes a multifunctional protein responsible for the essential C-terminal amidation of secreted peptides.</p> <p>Genetic screening was performed by germline and tumor sequencing and germline copy number variation (CNV) analysis. No germline CNVs or somatic single nucleotide variants (SNVs) were identified. We detected seven likely pathogenic heterozygous missense, truncating, and regulatory SNVs. These SNVs were found in sporadic subjects with GH excess (p.Gly552Arg and p.Phe759Ser), pediatric Cushing disease (c.-133T>C and p.His778fs), or with different types of PAs (c.-361G>A, p.Ser539Trp, and p.Asp563Gly). The SNVs were functionally tested <em>in vitro </em>for protein expression and trafficking by Western blotting, for splicing by minigene assays, and for amidation activity in cell lysates and serum samples. These analyses confirmed a deleterious effect on protein expression and/or function. By interrogating 200,000 exomes from the UK Biobank, we confirmed a significant association of the <em>PAM</em> gene and rare <em>PAM </em>SNVs to diagnoses linked to pituitary gland hyperfunction.</p> <p>Identification of <em>PAM </em>as a candidate gene associated with pituitary hypersecretion opens the possibility of developing novel therapeutics based on altering PAM function.</p>
Expression QTL (eQTL) mapping in the anterior pituitary gland using DES-treated COPxACI F2 rats.
GEO Series GSE4081. Rattus norvegicus. 43 samples. Type: Expression profiling by array.
Diethylstilbestrol effects on rat anterior pituitary gland
GEO Series GSE4083. Rattus norvegicus. 76 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.