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471
datasets available to search
ShareScore release 0.9.0
Dataset results
471 results for “Protein targets”
A Novel Cereblon Modulator Targets eRF3 Family Proteins For Cereblon-dependent Destruction
GEO Series GSE76195. Homo sapiens. 16 samples. Type: Expression profiling by array.
Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Proteins and Nuclear Responses for High-Light Acclimation
GEO Series GSE211805. Arabidopsis thaliana. 16 samples. Type: Expression profiling by array.
Bioresponsive lysosome-targeting chimeras for targeted protein degradation
GEO Series GSE295826. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeting RNA helicase ameliorates bortezomib resistance in glioblastoma via RNA dependent sequestration of protein phosphatase PPM1D
GEO Series GSE160875. Homo sapiens. 43 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Bone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investigated, the transcriptional targets mediating MYC effects in MB are still elusive. Their identification and roles during MB onset and progression are important and will ultimately suggest novel potential therapeutic targets. cDNA microarray analysis was used to compare the effects of overexpressing and silencing MYC on the transcriptome of a MB-derived cell line. We identified 209 genes with potential relevance to MYC-dependent cellular responses in MB. Among the MYC-responsive genes, we found members of the bone morphogenetic protein (BMP) signaling pathway, which plays a crucial role during the development of the cerebellum. In particular, the cytokine gene BMP7 was identified as a direct target of MYC in MB cells. Similar to the effect induced by BMP7 silencing by siRNA, the use of a small-molecule inhibitor of the BMP/SMAD signaling pathway reduced cell viability in a panel of MB cells. Altogether, our findings indicate that high MYC levels drive BMP7 expression in MB to induce pro-survival and pro-proliferative cellular pathways. This observation suggests that targeting the BMP/SMAD pathway may be a new therapeutic concept for the treatment of childhood MB.
RIP-seq: screening targeted-genes of RNA binding protein MEX3C
GEO Series GSE208371. Homo sapiens. 2 samples. Type: Other.
Comparison of STAMP and TRIBE for identifying the targets of RNA-binding proteins in human and Drosophila cells [human]
GEO Series GSE223556. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
Iso-CUT&MAP (Isolated cell-based Cut Under Target and Mapping Apoptotic Protein-binding sequences): a novel strategy for high-resolution mapping of DNA binding sites
GEO Series GSE237814. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation.
GEO Series GSE117899. Saccharomyces cerevisiae. 1 samples. Type: Expression profiling by high throughput sequencing.
C2H2-type zinc finger protein PagSUPa targets PHRAGMOPLAST ORIENTING KINESIN to negatively regulate cell division during leaf development in Populus alba × P. glandulosa
GEO Series GSE272768. Populus alba x Populus glandulosa. 12 samples. Type: Expression profiling by high throughput sequencing.
Protein Arginine Methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in Multiple Myeloma
GEO Series GSE103966. Homo sapiens. 4 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.