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1,705 results for “Vector”
Data from: Quantifying (non)parallelism of microbial community change using multivariate vector analysis
<p>Parallel evolution of phenotypic traits is regarded as strong evidence for natural selection and has been studied extensively in a variety of taxa. However, we have limited knowledge of whether parallel evolution of host organisms is accompanied by parallel changes of their associated microbial communities (i.e., microbiotas), which are crucial for their hosts' ecology and evolution. Determining the extent of microbiota parallelism in nature can improve our ability to identify the factors that are associated with (putatively adaptive) shifts in microbial communities. While it has been emphasized that (non)parallel evolution is better considered as a quantitative continuum rather than a binary phenomenon, quantitative approaches have rarely been used to study microbiota parallelism. We advocate using multivariate vector analysis (i.e., phenotypic change vector analysis) to quantify direction and magnitude of microbiota changes and discuss the applicability of this approach for studying parallelism. We exemplify its use by reanalyzing gut microbiota data from multiple fish species that exhibit parallel shifts in trophic ecology. This approach provides an analytical framework for quantitative comparisons across host lineages, thereby providing the potential to advance our capacity to predict microbiota changes. Hence, we encourage the development and application of quantitative measures, such as multivariate vector analysis, to better understand the role of microbiota dynamics during their hosts' adaptive evolution, particularly in settings of parallel evolution.</p>
Supplementary Video 1 Empty vector-LifeAct
<p>F-actin dynamics in pericytes co-transduced with mCherry-Lifeact and control empty lentiviral vectors.</p>
IG. 6. Ordination diagram of PCA of the Patagonian bat assemblage for craniodental variables using A) data set not size-corrected; and B) data set size-corrected. Polygons include specimens from each species: H. macrotus (▲), H. magellanicus (), H. montanus (▲), L. varius (■), M. chiloensis (●), and T. brasiliensis (£). Vectors show the strengh of correlation of each variable with the plane of PC1 and PC2. See text for abbreviations in Ecomorphological diversity in the Patagonian assemblage of bats from Argentina
IG. 6. Ordination diagram of PCA of the Patagonian bat assemblage for craniodental variables using A) data set not size-corrected; and B) data set size-corrected. Polygons include specimens from each species: H. macrotus (▲), H. magellanicus (), H. montanus (▲), L. varius (■), M. chiloensis (●), and T. brasiliensis (£). Vectors show the strengh of correlation of each variable with the plane of PC1 and PC2. See text for abbreviations
Ensemble Ecological Niche Models, in 2019 and across RCP 2.6, 4.5, and 8.5 scenarios in 2050 and 2100, of 1508 European Marine Species based on Ecological Niche Models developed with Artificial Neural Networks, Maximum Entropy, Support Vector Machines, and AquaMaps at 0.5° Resolution
<p>Ensemble Ecological Niche Models, in 2019 and across RCP 2.6, 4.5, and 8.5 scenarios in 2050 and 2100, of 1508 European marine species based on Ecological Niche Models developed with (i) Artificial Neural Networks, (ii) Maximum Entropy, (iii) Support Vector Machines, and (iv) AquaMaps at 0.5° Resolution. The data report, for each 0.5° cell, how many models (from 0 to 4) overcome a model-specific decision threshold to assess species presence in the cell.</p>
Chikungunya intra-vector infection dynamics in a French Aedes albopictus population reveals low vector barrier intensity and supports an explosive epidemic potential
<p>Arbovirus emergence and epidemic potential, as approximated by the vectorial capacity formula, depends on host and vector parameters, including the vector’s intrinsic ability to replicate then transmit the pathogen known as vector competence. Vector competence is a complex, time-dependent, quantitative phenotype influenced by biotic and abiotic factors. A combination of experimental and modelling approaches is required to assess arbovirus intra-vector dynamics and estimate its epidemic potential. In this study, we measured infection, dissemination, and transmission dynamics of chikungunya virus (CHIKV) in a field-derived <em>Aedes albopictus</em> population (Lyon metropolis, France) after oral exposure to a range of virus doses spanning human viraemia. Statistical modelling indicates rapid and efficient CHIKV progression in the vector mainly due to an absence of a dissemination barrier, with 100% of the infected mosquitoes ultimately exhibiting a disseminated infection, regardless of the virus dose. Transmission rate data revealed a time-dependent, but overall weak, transmission barrier, with individuals transmitting as soon as 2 days post-exposure (dpe) and >50% infectious mosquitoes at 6 dpe for the highest dose. Based on these experimental intra-vector dynamics data, epidemiological simulations conducted with an agent-based model showed that even at low mosquito biting rates, CHIKV could trigger explosive outbreaks. Together, this reveals the high epidemic potential of CHIKV upon transmission by <em>Aedes albopictus</em> in mainland France.</p>
A first high-quality vector data of buildings in East Asian countries based on a comprehensive large-scale mapping framework
<p>We generate a high-quality and complete vector data of buildings in East Asian regions, including China, Japan, North Korea, South Korea and Mongolia, filling the gaps in the existing public buildings data.</p>
Dose-Escalation Study Of A Self Complementary Adeno-Associated Viral Vector For Gene Transfer in Hemophilia B
ClinicalTrials.gov study NCT00979238. IPD Sharing: Not stated. Countries: 2. Publications: 3.
ß-Thalassemia Major with Autologous CD34+ Hematopoietic Progenitor Cells Transduced with TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin Gene
ClinicalTrials.gov study NCT01639690. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca 6)
ClinicalTrials.gov study NCT02576665. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Phase 1, Randomized, Blinded, Dose-escalation Study of rAAV1-PG9DP Recombinant AAV Vector Coding for PG9 Antibody in Healthy Male Adults.
ClinicalTrials.gov study NCT01937455. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Adjuvanting Viral Vectored Malaria Vaccines With Matrix M
ClinicalTrials.gov study NCT01669512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase I Clinical Trial to Evaluate the Ebola Adenovirus Vector Vaccine (Ad5-EBOV) in Healthy Adults.
ClinicalTrials.gov study NCT02326194. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Field Evaluations of Innovative Tools for Vector-borne Disease Control in Conflict-affected Communities
ClinicalTrials.gov study NCT06179732. IPD Sharing: NO. Countries: 1. Publications: 1.
Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children
ClinicalTrials.gov study NCT03534245. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT
ClinicalTrials.gov study NCT01261585. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of HGF Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia
ClinicalTrials.gov study NCT00060892. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, and Immunogenicity of the Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO), VRC-EBOADC069-00-VP, in Healthy Adults
ClinicalTrials.gov study NCT02231866. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma
ClinicalTrials.gov study NCT01156584. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations
ClinicalTrials.gov study NCT00481546. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Safety and Immune Response to Preventive HIV Immunization With Adenovirus Serotype 5 or 35 Vector
ClinicalTrials.gov study NCT00801697. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.