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1,052
datasets available to search
ShareScore release 0.9.0
Dataset results
1,052 results for “cardiomyocytes”
Effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes [methylation]
GEO Series GSE144425. Homo sapiens. 72 samples. Type: Methylation profiling by genome tiling array.
Injury-Induced CLU-Positive Cardiomyocytes Drive Metabolic Reprogramming of Macrophage Function in Heart Regeneration [Spatial Transcriptomics]
GEO Series GSE254055. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
FOXO-inhibited iPSC-derived cardiomyocytes compared against DMSO vehicle controls.
GEO Series GSE252627. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
<p>The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes. In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripotent stem cells (iPSC), since this process may strongly influence cell fate and, thus, augment the precision of differentiation into specific cell types, e.g., cardiomyocytes. The decryption of the cellular machinery starting from ECM sensing to iPSC differentiation calls for new <em>in vitro</em> methods. Conveniently, engineered biomaterials activating controlled integrin-mediated responses through chemical, physical, and geometrical designs are key to resolving this issue and could foster clinical translation of optimized iPSC-based technology. This review introduces the main integrin-dependent mechanisms and signalling pathways involved in mechanotransduction. Special consideration is given to the integrin-iPSC linkage signalling chain in the cardiovascular field, focusing on biomaterial-based <em>in vitro</em> models to evaluate the relevance of this process in iPSC differentiation into cardiomyocytes.</p>
Dataset for "Comparing Neural Network Based Segmentation of Cardiomyocytes from Different Histology Data"
<p>This dataset contains the trained UNet TensorFlow network, the raw (tiled) histology images, and input and output inference data. The data was used for the work presented at the ISMRM Workshop on Machine Learning in 2018.</p>
Data from: Determining the genetic basis of anthracycline-cardiotoxicity by response QTL mapping in induced cardiomyocytes
Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal chemotherapy regimes, with almost half of patients expected to develop congestive heart failure given high doses. However, the genetic basis of sensitivity to anthracyclines remains unclear. We created a panel of iPSC-derived cardiomyocytes from 45 individuals and performed RNA-seq after 24h exposure to varying doxorubicin dosages. The transcriptomic response is substantial: the majority of genes are differentially expressed and over 6000 genes show evidence of differential splicing, the later driven by reduced splicing fidelity in the presence of doxorubicin. We show that inter-individual variation in transcriptional response is predictive of in vitro cell damage, which in turn is associated with in vivo ACT risk. We detect 447 response-expression QTLs and 42 response-splicing QTLs, which are enriched in lower ACT GWAS p-values, supporting the in vivo relevance of our map of gene tic regulation of cellular response to anthracyclines.
Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte Differentiation - Supplementary Data
<p>Genotype data for 19 cell lines from the Yoruba HapMap population that were used in this study, and summary statistics from QTL calling (see README.md in summary.zip).</p>
IPS Differentiated Cardiomyocytes Vein Transplantation for Chronic Heart Failure
ClinicalTrials.gov study NCT03759405. IPD Sharing: NO. Countries: 1. Publications: 0.
Allogeneic iPSC-derived Cardiomyocyte Therapy in Patients With Worsening Ischemic Heart Failure
ClinicalTrials.gov study NCT05566600. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Trial of Human (Allogeneic) iPS Cell-derived Cardiomyocytes Sheet for Ischemic Cardiomyopathy
ClinicalTrials.gov study NCT04696328. IPD Sharing: NO. Countries: 1. Publications: 0.
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer)
ClinicalTrials.gov study NCT03541213. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of iPS Cell-derived Cardiomyocyte Spheroids (HS-001) in Patients With Heart Failure (LAPiS Study)
ClinicalTrials.gov study NCT04945018. IPD Sharing: NO. Countries: 1. Publications: 0.
Potential Effects of Omega 3 Supplementation on Cardiomyocytes Membranes for Patients With Coronary Atherosclerosis?
ClinicalTrials.gov study NCT01699230. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cardiomyocyte Apoptosis Following Antegrade and Retrograde Cardioplegia
ClinicalTrials.gov study NCT01185912. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular Dysfunction
ClinicalTrials.gov study NCT05068674. IPD Sharing: NO. Countries: 1. Publications: 0.
Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation
GEO Series GSE156394. Homo sapiens. 51 samples. Type: Expression profiling by high throughput sequencing.
miRNA profiling in adult rat cardiomyocytes and myocyte-derived progenitor cells
GEO Series GSE24252. Mus musculus; Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by array.
Titin truncating variantsin hiPSC-cardiomyocytes inducepathogenic proteinopathy, sarcomeredefect and contractile dysfunction independent of the core contractilemachinery
GEO Series GSE183218. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
OXPHOS driven by glycolysis through the malate aspartate shuttle is required for cardiomyocyte re-differentiation and long-term fish heart regeneration [Astyanax_mexicanus_RNAseq]
GEO Series GSE234989. Astyanax mexicanus. 96 samples. Type: Expression profiling by high throughput sequencing.
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes
GEO Series GSE187308. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.