Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
502
datasets available to search
ShareScore release 0.9.0
Dataset results
502 results for “natural populations”
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations
GEO Series GSE283335. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing; Other.
Genetic ancestry and natural selection drive population differences in immune responses to pathogens in humans
GEO Series GSE81046. Homo sapiens. 503 samples. Type: Expression profiling by high throughput sequencing.
Effects of Changes in Food Supply at the Time of Sex Differentiation on the Gonadal Transcriptome of Juvenile Fish. Implications for Natural and Farmed Populations
GEO Series GSE54362. Dicentrarchus labrax. 35 samples. Type: Expression profiling by array.
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [CRISPR screen]
GEO Series GSE311810. Homo sapiens. 46 samples. Type: Other.
The transcriptomic and physiological basis of desiccation stress response in natural European D. melanogaster populations
GEO Series GSE196669. Drosophila melanogaster. 36 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Epigenetic inheritance mediates phenotypic evolution in natural populations
GEO Series GSE183785. Arabidopsis thaliana. 25 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Functional genomic and phenotypic responses to desiccation in natural populations of a desert drosophilid.
GEO Series GSE43220. Drosophila mojavensis. 95 samples. Type: Expression profiling by array.
Natural Microbial exposure populates the maternal fetal interface with diverse T cells.
GEO Series GSE293451. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The transcriptomic and physiological basis of desiccation stress response in natural European D. melanogaster populations
GEO Series GSE153850. Drosophila melanogaster. 36 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [scRNA-seq]
GEO Series GSE311811. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic plasticity of mesophotic corals among natural populations and transplants of Montastraea cavernosa in the Gulf of Mexico and Belize
GEO Series GSE107688. Montastraea cavernosa. 311 samples. Type: Expression profiling by high throughput sequencing.
Genetic and transcriptomic basis of copper tolerance across natural European Drosophila melanogaster populations
GEO Series GSE154608. Drosophila melanogaster. 34 samples. Type: Expression profiling by high throughput sequencing.
Different developmental pathways generate functionally distinct populations of natural killer cells
GEO Series GSE266109. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing; Other.
A mechanistic basis for genetic assimilation in natural fly populations
GEO Series GSE255494. Drosophila melanogaster. 72 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations [xenograft]
GEO Series GSE311813. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Data from: Mixture modeling of transcript abundance classes in natural populations
BACKGROUND: Populations diverge in genotype and phenotype under the influence of such evolutionary processes as genetic drift, mutation accumulation, and natural selection. Because genotype maps onto phenotype by way of transcription, it is of interest to evaluate how these evolutionary factors influence the structure of variation at the level of transcription. Here, we explore the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance among individuals within populations. RESULTS: Expression profiling using cDNA microarrays was conducted in Drosophila melanogaster adult female heads for 58 nearly isogenic lines from a North Carolina population and 50 from a California population. Using a mixture modeling approach, transcripts were identified that exhibit more than one mode of transcript abundance across the samples. Power studies indicate that sample sizes of 50 individuals will generally be sufficient to detect divergent transcript abundance classes. The distribution of transcript abundance classes is skewed toward low frequency minor classes, which is reminiscent of the typical skew in genotype frequencies. Similar results are observed in reported data on gene expression in human lymphoblast cell lines, in which analysis of association with linked polymorphisms implies that cis-acting single nucleotide polymorphisms make only a modest contribution to bimodal distributions of transcript abundance. CONCLUSION: Population surveys of gene expression may complement genetical genomics as a general approach to quantifying sources of transcriptional variation. Differential expression of transcripts among individuals is due to a complex interplay of cis-acting and trans-acting factors.
Data from: Contrasting pattern of natural variation in global Drosophila melanogaster populations
Despite the popularity of Drosophila melanogaster in functional and evolutionary genetics, the global pattern of natural variation has not yet been comprehensively described in this species. For the first time, we report a combined survey using neutral microsatellites and mitochondrial sequence variation jointly. Thirty-five populations originating from five continents were compared. In agreement with previous microsatellite studies, sub-Saharan African populations were the most variable ones. Consistent with previous reports of a single 'out of Africa' habitat expansion, we found that non-African populations contained a subset of the African alleles. The pattern of variation detected for the mitochondrial sequences differed substantially. The most divergent haplotypes were detected in the Mediterranean region while Africa harbored most haplotypes, which were all closely related. In the light of the well-established African origin of D. melanogaster, our results cast severe doubts about the suitability of mtDNA for biogeographic inference in this model organism.
Data for "Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint"
<p>Data associated with the manuscript:</p> <p>"Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint"</p> <p>Please see code/documentation associated with these data at the links below: </p> <p>Analysis code + documentation: <a href="https://niaid.github.io/fsc/">https://niaid.github.io/fsc/</a></p> <p>Analysis code Github repository: <a href="https://github.com/niaid/fsc">https://github.com/niaid/fsc</a></p> <p>In the downloaded directory the subdirectory 'data' contains data files including: </p> <p><strong>flu_vacc_CITEseq_Seurat4.rds </strong>is CITE-seq data as a Seurat version 4 object for R. </p> <p><strong>flu_vacc_CITEseq_combinedassay.h5ad</strong> is CITE-seq data as a .h5ad object for python. </p>
Figure 1 in Hucho hucho (Linnaeus, 1758): last natural viable population in the Eastern Carpathians - conservation elements
Figure 1. Location of the 370 sampling stations in the nature park.
Figure 2. H in Hucho hucho (Linnaeus, 1758): last natural viable population in the Eastern Carpathians - conservation elements
Figure 2. H. hucho capture locations.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.